Moderate Cosmetic Ingredient Sensitization Data

Hydroxypropyl Methacrylate

INCI: HYDROXYPROPYL METHACRYLATE

CAS Number
27813-02-1 (mixture of isomers); 923-26-2 (primary isomer)
Function
Nail builder / nail enhancement monomer
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted โ€” CIR: safe as used in nail enhancement products when labeled to avoid skin contact

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Sensitization Profile

Contact sensitization data for Hydroxypropyl Methacrylate based on clinical patch test studies and IFRA standards.

Sensitization Rate
low
Allergen Class
other
EU Allergen Listed
no
Patch Test Positive Rate
0.5%
Cross-reactivity Group
acrylate-group
Reaction Type
contact-dermatitis

Source: IVDK

Expert Verdict

CIR restricts use to nail products only with labeling to avoid skin contact; known skin sensitizer with methacrylate cross-reactivity and serious eye irritation risk; may cause hypersensitivity or allergic reactions in humans.

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Concern Level: High

Regulatory Flags

potential-allergen

Frequently Asked Questions

Is Hydroxypropyl Methacrylate safe in cosmetics?

CIR restricts use to nail products only with labeling to avoid skin contact; known skin sensitizer with methacrylate cross-reactivity and serious eye irritation risk; may cause hypersensitivity or allergic reactions in humans. The EU classifies Hydroxypropyl Methacrylate as "permitted". Safety rating: MODERATE.

Is Hydroxypropyl Methacrylate allowed in the EU?

Hydroxypropyl Methacrylate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Hydroxypropyl Methacrylate do in cosmetics?

Hydroxypropyl Methacrylate functions as: Nail builder / nail enhancement monomer. It is classified as a cosmetic ingredient in our database. CAS number: 27813-02-1 (mixture of isomers); 923-26-2 (primary isomer).

What is the Margin of Safety for Hydroxypropyl Methacrylate?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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