Hydroxypropyl Methylcellulose Phthalate

INCI: HYDROXYPROPYL METHYLCELLULOSE PHTHALATE

CAS Number
9050-31-1 [^1_2]
Function
Film forming; enteric coating polymer
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted โ€” no 21 CFR prohibition; widely used as pharmaceutical excipient in FDA Inactive Ingredient Database

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
negligible
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Polymer-bound phthalate moiety structurally distinct from low-MW phthalate esters but may draw regulatory scrutiny under phthalate-class restrictions; SDS lists Health rating 1 (minor irritation).

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Concern Level: Moderate

Frequently Asked Questions

Is Hydroxypropyl Methylcellulose Phthalate safe in cosmetics?

Polymer-bound phthalate moiety structurally distinct from low-MW phthalate esters but may draw regulatory scrutiny under phthalate-class restrictions; SDS lists Health rating 1 (minor irritation). The EU classifies Hydroxypropyl Methylcellulose Phthalate as "permitted". Safety rating: MODERATE.

Is Hydroxypropyl Methylcellulose Phthalate allowed in the EU?

Hydroxypropyl Methylcellulose Phthalate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Hydroxypropyl Methylcellulose Phthalate do in cosmetics?

Hydroxypropyl Methylcellulose Phthalate functions as: Film forming; enteric coating polymer. It is classified as a cosmetic ingredient in our database. CAS number: 9050-31-1 [^1_2].

What is the Margin of Safety for Hydroxypropyl Methylcellulose Phthalate?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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