Is Indolino Trimethylspiroindoline Naphthooxazine safe in cosmetics?
Indolino Trimethylspiroindoline Naphthooxazine has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Indolino Trimethylspiroindoline Naphthooxazine
INCI: INDOLINO TRIMETHYLSPIROINDOLINE NAPHTHOOXAZINE
Indolino Trimethylspiroindoline Naphthooxazine (CAS 114747-44-3) is a cosmetic cosmetic ingredient functioning as Photochromic agent (UV-responsive color change). EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 114747-44-3 →
Auto-generated CPSR Part A draft with source citations
Function
Photochromic agent (UV-responsive color change)
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
6-(2,3-dihydroindol-1-yl)-1',3',3'-trimethylspiro[benzo[f][1,4]benzoxazine-3,2'-indole]
InChIKey
PITZBBWQUBGWTD-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — not on FDA prohibited/restricted lists; if used as a colorant, would require 21 CFR Part 73/74 review
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Indolino Trimethylspiroindoline Naphthooxazine.
Calculate MoS for your specific formulation with the MoS Calculator.
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dye
Expert Verdict
Expert safety assessment and concern-level summary for Indolino Trimethylspiroindoline Naphthooxazine.
Chemical Function
Dye
Australian Status
AICIS status: listed_with_terms
Specific information requirements: Obligations to provide information apply. These obligations are: 1. If the assessment report about the chemical recommends secondary notification of the chemical in particular circumstances and any of the circumstances occur in relation to the introduction (importation or manufacture) of the chemical by a person, then the...
Frequently Asked Questions
Is Indolino Trimethylspiroindoline Naphthooxazine allowed in the EU?
Indolino Trimethylspiroindoline Naphthooxazine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Indolino Trimethylspiroindoline Naphthooxazine do in cosmetics?
Indolino Trimethylspiroindoline Naphthooxazine functions as: Photochromic agent (UV-responsive color change). It is classified as a cosmetic ingredient in our database. CAS number: 114747-44-3.
Is Indolino Trimethylspiroindoline Naphthooxazine used outside cosmetics?
Indolino Trimethylspiroindoline Naphthooxazine also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Indolino Trimethylspiroindoline Naphthooxazine compliance across multiple jurisdictions:
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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