Indolino Trimethylspiroindoline Naphthooxazine

INCI: INDOLINO TRIMETHYLSPIROINDOLINE NAPHTHOOXAZINE

CAS Number
114747-44-3
Function
Photochromic agent (UV-responsive color change)
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted โ€” not on FDA prohibited/restricted lists; if used as a colorant, would require 21 CFR Part 73/74 review

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

GHS skin/eye/respiratory irritant classifications (H315, H319, H335). Photochromic behavior means UV-activated structural change in situ; assess photostability and photo-degradant toxicity. No SCCS or CIR opinion. If classified as a colorant, regulatory pathway changes significantly.

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Concern Level: Moderate

Frequently Asked Questions

Is Indolino Trimethylspiroindoline Naphthooxazine safe in cosmetics?

GHS skin/eye/respiratory irritant classifications (H315, H319, H335). Photochromic behavior means UV-activated structural change in situ; assess photostability and photo-degradant toxicity. No SCCS or CIR opinion. If classified as a colorant, regulatory pathway changes significantly. The EU classifies Indolino Trimethylspiroindoline Naphthooxazine as "permitted". Safety rating: MODERATE.

Is Indolino Trimethylspiroindoline Naphthooxazine allowed in the EU?

Indolino Trimethylspiroindoline Naphthooxazine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Indolino Trimethylspiroindoline Naphthooxazine do in cosmetics?

Indolino Trimethylspiroindoline Naphthooxazine functions as: Photochromic agent (UV-responsive color change). It is classified as a cosmetic ingredient in our database. CAS number: 114747-44-3.

What is the Margin of Safety for Indolino Trimethylspiroindoline Naphthooxazine?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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