Inositol Hexanicotinate

INCI: INOSITOL HEXANICOTINATE

CAS Number
6556-11-2
Function
Skin conditioning (niacin derivative — vasodilation, barrier support)
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Permitted — also used as a dietary supplement (flush-free niacin); EFSA has assessed oral safety

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

No specific CIR cosmetic safety assessment; at high topical concentrations may cause localized flushing/erythema from nicotinic acid release; characterize hydrolysis rate in formulation

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Concern Level: Low

Frequently Asked Questions

Is Inositol Hexanicotinate safe in cosmetics?

No specific CIR cosmetic safety assessment; at high topical concentrations may cause localized flushing/erythema from nicotinic acid release; characterize hydrolysis rate in formulation The EU classifies Inositol Hexanicotinate as "permitted". Safety rating: GOOD.

Is Inositol Hexanicotinate allowed in the EU?

Inositol Hexanicotinate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Inositol Hexanicotinate do in cosmetics?

Inositol Hexanicotinate functions as: Skin conditioning (niacin derivative — vasodilation, barrier support). It is classified as a cosmetic ingredient in our database. CAS number: 6556-11-2.

What is the Margin of Safety for Inositol Hexanicotinate?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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