Good Cosmetic Ingredient Dermal Penetration

Inositol Hexaphosphate (Phytic Acid)

INCI: PHYTIC ACID

CAS Number
83-86-3
Function
Chelating agent
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Permitted — CIR assessed as safe (2024); also GRAS for food use

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Dermal Penetration Profile

Skin absorption and penetration characteristics of Inositol Hexaphosphate (Phytic Acid), relevant to systemic exposure and MoS calculations.

Absorption %
0.1-0.5%
Penetration Level
surface
Penetration Depth
surface only
Molecular Weight
660.0 Da
Log P
-5.5
Systemic Absorption
minimal
Topical Bioavailability
0.05-0.2%
Safety Margin Factor
minimal
Vehicle Dependent
Yes — absorption varies by formulation

Source: Cosmetic Science

Expert Verdict

Concentrated form is corrosive (skin corrosive Category 1, acute oral toxicity Category 4); must be diluted appropriately. Strong chelator may destabilize formulations containing metal-dependent preservatives or actives. pH-sensitive—verify final product pH.

⚠️
Concern Level: Low

Regulatory Flags

eu_children_restricted

Frequently Asked Questions

Is Inositol Hexaphosphate (Phytic Acid) safe in cosmetics?

Concentrated form is corrosive (skin corrosive Category 1, acute oral toxicity Category 4); must be diluted appropriately. Strong chelator may destabilize formulations containing metal-dependent preservatives or actives. pH-sensitive—verify final product pH. The EU classifies Inositol Hexaphosphate (Phytic Acid) as "permitted". Safety rating: GOOD.

Is Inositol Hexaphosphate (Phytic Acid) allowed in the EU?

Inositol Hexaphosphate (Phytic Acid) EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Inositol Hexaphosphate (Phytic Acid) do in cosmetics?

Inositol Hexaphosphate (Phytic Acid) functions as: Chelating agent. It is classified as a cosmetic ingredient in our database. CAS number: 83-86-3.

What is the Margin of Safety for Inositol Hexaphosphate (Phytic Acid)?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Compliance Tools

Check Inositol Hexaphosphate (Phytic Acid) compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
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Substance Compliance
Check compliance across 55 jurisdictions
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
Compare limits across jurisdictions

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