Good Cosmetic Ingredient Dermal Penetration

Inositol Hexaphosphate (Phytic Acid)

INCI: PHYTIC ACID

Inositol Hexaphosphate (Phytic Acid) (CAS 83-86-3) is a cosmetic cosmetic ingredient functioning as Chelating agent. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety, pharmaceutical, and food safety data.

View industrial chemical safety profile for CAS 83-86-3 →

Auto-generated CPSR Part A draft with source citations
CAS Number
83-86-3
View industrial chemical safety profile →
Function
Chelating agent
Safety Rating
GOOD

Chemistry & Identifiers

Formula
C6H18O24P6
MW
660.04 g/mol
EC Number
201-506-6
PubChem CID
890
IUPAC Name
(2,3,4,5,6-pentaphosphonooxycyclohexyl) dihydrogen phosphate
InChIKey
IMQLKJBTEOYOSI-UHFFFAOYSA-N
ChEBI: CHEBI:17401 UNII: 7IGF0S7R8I Wikidata: Q409679

Regulatory Status

EU EU Status permitted
US US Status permitted
US Notes Permitted — CIR assessed as safe (2024); also GRAS for food use

For full compliance data across multiple jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety, dermal absorption, and sensitization profile summaries for Inositol Hexaphosphate (Phytic Acid).

Calculate MoS for your specific formulation with the MoS Calculator.

Dermal Penetration Profile

Skin absorption and penetration characteristics of Inositol Hexaphosphate (Phytic Acid), relevant to systemic exposure and MoS calculations.

Absorption %
0.1-0.5%
Penetration Level
surface
Penetration Depth
surface only
Molecular Weight
660.0 Da
Log P
-5.5
Systemic Absorption
minimal
Topical Bioavailability
0.05-0.2%
Safety Margin Factor
minimal
Vehicle Dependent
Yes — absorption varies by formulation

Source: Cosmetic Science

EPA ToxValDB — Toxicity Values

5 toxicity values from EPA ToxValDB (aggregated from CCTE, HPV, ToxRefDB, IRIS, and other regulatory dossiers).

Endpoint Value Species Route Duration Source
LD50 ~900 mg/kg Mouse oral - ECHA
LD50 ~1150 mg/kg Mouse oral - ECHA
LD50 =1150 mg/kg Mouse oral - ECHA
LD50 =1160 mg/kg Mouse oral - ECHA
LD50 =900 mg/kg Mouse oral - ECHA

ECHA REACH Registration

European Chemicals Agency REACH dossier and Substances of Very High Concern listing.

Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No

Additional Ingredient Properties

10 property records from structured ingredient metadata.

acne
{"cas_number": "83-86-3", "anti_acne_mechanism": "keratolytic/anti_inflammatory", "comedogenicity_rating_0_to_5": "0", "acne_type_efficacy": "non_inflammatory/inflammatory", "sebum_reduction_pct_clinical": "5-10", "keratolytic_strength": "mild", "exfoliation_mechanism": "chemical", "optimal_ph_for_efficacy": "3.5-5.0", "peel_depth": "superficial", "prescription_required_usa": "No", "otc_drug_monog…
anti_aging
{"anti_aging_claim": "brightening, antioxidant-protection", "mechanism_of_action": "Exfoliation, cell turnover acceleration, keratolytic", "target_skin_layer": "stratum corneum, epidermis", "collagen_stimulation": "Mild", "elastin_protection": "Mild", "wrinkle_reduction_pct": "8-15", "clinical_study_duration_weeks": "12", "sample_size": "40", "double_blind": "No", "placebo_controlled": "Yes", "pub…
baby_pediatric
{"cas_number": "83-86-3", "ingredient_class": "other", "pediatric_safety_rating": "excellent", "minimum_age_months": "0", "neonatal_safe": "yes", "premature_infant_safe": "yes", "skin_barrier_maturity_consideration": "Natural chelator, rice/corn", "transepidermal_absorption_risk_pediatric": "low", "systemic_exposure_concern_pediatric": "low", "dose_per_kg_body_weight_concern": "Chelator/buffer fun…
concentration
{"min_concentration_pct": "0.5", "max_concentration_pct": "2.0", "typical_concentration_pct": "1.0", "product_type": "Toner", "function_at_concentration": "Brightening", "source": "Supplier TDS"}
cost_pricing
{"cost_tier": "mid-range", "estimated_cost_per_kg_usd_low": "35", "estimated_cost_per_kg_usd_high": "65", "natural_premium_markup_pct": "45", "organic_certified_premium_pct": "85", "supply_chain_volatility": "low", "primary_source_region": "China/Europe", "synthetic_vs_natural_cost_ratio": "2.0", "bulk_discount_threshold_kg": "50", "seasonal_price_variation": "low", "commodity_or_specialty": "spec…
deodorant
{"cas_number": "83-86-3", "ingredient_class": "other", "mechanism_of_action": "metal_ion_chelation", "antiperspirant_efficacy_sweat_reduction_pct": "0", "deodorant_efficacy_hours": "0", "odor_reduction_pct": "0", "bacteriostatic": "no", "bactericidal": "no", "microbiome_impact": "neutral", "axillary_microbiome_effect": "varies by ingredient", "MIC_value_if_antimicrobial": "varies", "astringency_le…
dermal_absorption
{"molecular_weight_da": "660.0", "log_p_value": "-5.5", "skin_penetration_level": "surface", "penetration_depth": "surface only", "absorption_pct": "0.1-0.5", "systemic_absorption": "minimal", "penetration_enhancer": "no", "occlusion_effect": "no", "vehicle_dependent": "yes", "skin_barrier_effect": "neutral", "bioavailability_topical_pct": "0.05-0.2", "safety_margin_factor": "minimal", "source": "…
ecotoxicity
{"biodegradable": "yes", "biodegradation_days": "28-60", "bioaccumulative": "no", "aquatic_toxicity_level": "low", "coral_reef_safe": "yes", "marine_toxicity": "low aquatic toxicity", "freshwater_toxicity": "minimal impact", "endocrine_disruptor": "no", "persistent_organic_pollutant": "no", "microplastic": "no", "nano_particle": "no", "hawaii_banned": "no", "eu_restricted_environmental": "no", "pa…

Function Categories & List Membership

Cosmetic/Chemical Function Categories
Chelating agent
Regulatory List Membership (1)
EU Restricted for Children (Cosmetics)

Expert Verdict

Expert safety assessment and concern-level summary for Inositol Hexaphosphate (Phytic Acid).

Regulatory Flags

eu_children_restricted

Chemical Function

Chelating agent

Regulatory Lists

pharmaceutical Canada; pharmaceutical children; Europe; Personal care children; Europe; Personal care - general moisturizing - hand/body lotion children; Europe; Personal care - dental care - toothpaste Europe; Personal care - oral and dental care - teeth whitener Europe; Personal care - oral and dental care - teeth whitener children; Europe; Personal care children; Europe; Personal care - general moisturizing - hand/body lotion children; Europe; Personal care - dental care - toothpaste Europe; Personal care - oral and dental care - teeth whitener Europe; Personal care - oral and dental care - teeth whitener

Australian Status

AICIS status: listed

Cross-Vertical Safety Context

Same-CAS public records found in pharmaceutical and food safety data.

SOURCE ChEMBL / DrugCentral / FAERS DB_PHARMA CAS match

Pharmaceutical Data

Same-CAS rows from the pharmaceutical spoke database.

Compound
PHYTIC ACID
ChEMBL ID
CHEMBL1233511
Max Phase
3
Adverse Event Associations
11
View full pharmaceutical profile →
SOURCE EFSA / FDA GRAS food_additives + fda_gras_enriched

Food Safety Data

Same-CAS food additive or FDA GRAS records from the core public database.

Food Name
Phytic acid
FDA GRAS
FDA has no questions
GRN
381
Food Category
preservative

As an antioxidant, chelating agent, and antimicrobial agent in beverages and beverage bases, milk products, processed vegetables, and vegetable juices at a level of 0.2% Use in limiting solubility reduction and providing strength to dietary supplement...

View full food safety profile →

Frequently Asked Questions

Is Inositol Hexaphosphate (Phytic Acid) safe in cosmetics?

Inositol Hexaphosphate (Phytic Acid) has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.

Is Inositol Hexaphosphate (Phytic Acid) allowed in the EU?

Inositol Hexaphosphate (Phytic Acid) EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Inositol Hexaphosphate (Phytic Acid) do in cosmetics?

Inositol Hexaphosphate (Phytic Acid) functions as: Chelating agent. It is classified as a cosmetic ingredient in our database. CAS number: 83-86-3.

Is Inositol Hexaphosphate (Phytic Acid) used outside cosmetics?

Inositol Hexaphosphate (Phytic Acid) also appears in industrial chemical safety, pharmaceutical, and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.

Does Inositol Hexaphosphate (Phytic Acid) have different safety status in cosmetics vs industrial chemicals?

Inositol Hexaphosphate (Phytic Acid) is classified GHS Danger (H290, H302, H314, H318, H335) in the chemicals database but is allowed in EU cosmetics.

Compliance Tools

Check Inositol Hexaphosphate (Phytic Acid) compliance across multiple jurisdictions:

Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions

Related Ingredients

Acrylates/Vinyl Neodecanoate Crosspolymer
Excellent Same category
Emulsion stabilising, film forming
Adipic Acid
Excellent Same category
Buffering
Aluminum Magnesium Oxide
Excellent Same category
Absorbent, bulking agent, opacifying ...
Ammonium VA/Acrylates Copolymer
Excellent Same category
Antistatic, binding, film forming, ha...
Ammonium VA/Crotonic Acid Copolymer
Excellent Same category
Antistatic, film forming, hair fixing...
Aphanothece Sacrum Polysaccharide
Excellent Same category
Absorbent, emulsion stabilising, film...
(AGARICUS BLAZEI FERMENT + GANODERMA LUCIDUM FERMENT + GANODERMA MULTIPILEUM FERMENT) EXTRACT
Good Similar safety
Anti-sebum, Antioxidant, Skin Protecting
(ANGELICA ACUTILOBA/PAEONIA LACTIFLORA/REHMANNIA GLUTINOSA) ROOT/CNIDIUM OFFICINALE RHIZOME EXTRACT
Good Similar safety
Skin Conditioning, Skin Conditioning ...
(ANGELICA ACUTILOBA/PAEONIA LACTIFLORA/REHMANNIA GLUTINOSA/SCUTELLARIA BAICALENSIS) ROOT/(CNIDIUM OFFICINALE/COPTIS CHINENSIS) RHIZOME/GARDENIA JASMINOIDES FRUIT/PHELLODENDRON CHINENSE BARK EXTRACT
Good Similar safety
(ANGELICA GIGAS/GLYCYRRHIZA URALENSIS/REHMANNIA GLUTINOSA ROOT)/ANGELICA GIGAS STEM/CARTHAMUS TINCTORIUS FLOWER/(CARTHAMUS TINCTORIUS/PRUNUS PERSICA SEED)PORIA COCOS WATER
Good Similar safety
Humectant, Skin Conditioning, Skin Pr...
(ANGELICA KEISKEI/CHRYSANTHEMUM ZAWADSKII) LEAF/STEM/CINNAMOMUM CASSIA BARK/TRICHOSANTES KIRILOWII FRUIT/ULMUS DAVIDIANA BARK/ROOT/(PAEONIA JAPONICA/BUPLEURUM FALCATUM/POLYGALA TENUIFOLIA ROOT)/VISCUS ALBUM STEM EXTRACT
Good Similar safety
Anti-seborrheic, Anti-sebum, Antioxid...
(APPLE/CITRUS JUNOS/LENTIL/PEAR/PUMPKIN/STRAWBERRY/TOMATO FRUIT)/CORN KERNEL/(ARCTIUM LAPPA/BRASSICA OLERACEA ACEPHALA/CABBAGE/CAMELLIA SINENSIS/MORINGA OLEIFERA/RADISH/SPINACH LEAF)/(SORGHUM BICOLOR LEAF/STEM)/OAT MEAL/POTATO PULP/(CARROT/NELUMBO NUCIFERA/RADISH/WILD YAM ROOT)/(AMARANTHUS HYPOCHONDRIACUS/CASHEW/CICER ARIETINUM/COIX LACRYMA-JOBI MA-YUEN /MACADAMIA TERNIFOLIA/PHASEOLUS ANGULARIS/PISTACIA VERA/RHYNCHOSIA NULUBILIS/RICE/SESAME/SETARIA ITALICA/SOYBEAN/SWEET ALMOND/WHEAT SEED)/HORDEUM VULGARE SPROUT/CYPERUS ESCULENTUS TUBER/ARTEMISIA PRINCEPS/BROCCOLI/CHENOPODIUM QUINOA/ENTEROMORPHA COMPRESSA/HORDEUM VULGARE/IPOMOEA BATATAS/LAMINARIA JAPONICA/LENTINUS EDODES/PLEUROTUS OSTREATUS/PORPHYRA TENERA/UNDARIA PINNATIFIDA EXTRACT
Good Similar safety
Antioxidant
1,5-Naphthalenediol
Moderate Chemical family
Hair dye precursor/coupler — reacts w...
Amylisoeugenol
Moderate Chemical family
Perfuming
Beta-Sitosterol
Excellent Chemical family
emulsion stabilising, skin conditioni...
Browse all 30,000+ ingredients A-Z →

Is Inositol Hexaphosphate (Phytic Acid) in Your Products?

Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.

Try Piro Free →

Analyze Your Full Ingredient List

Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Inositol Hexaphosphate (Phytic Acid) in your formulation.

Ingredient Decoder MoS Calculator