Is Isatin safe in cosmetics?
Isatin has a safety rating of "MODERATE" in our database. EU status: prohibited. US status: permitted.
Moderate
Cosmetic Ingredient
Isatin
INCI: ISATIN
Isatin (CAS 91-56-5 [^1_1]) is a cosmetic cosmetic ingredient functioning as Hair colorant (oxidative and non-oxidative hair dye, up to 1.6% on-head). EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 91-56-5 [^1_1] →
Auto-generated CPSR Part A draft with source citations
Function
Hair colorant (oxidative and non-oxidative hair dye, up to 1.6% on-head)
Safety Rating
MODERATE
Regulatory Status
EU EU Status
prohibited
US US Status
permitted
US Notes
Permitted — no specific CFR restriction; coal-tar hair dye exemption (21 CFR 73/74) may apply depending on classification
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Isatin.
Calculate MoS for your specific formulation with the MoS Calculator.
Expert Verdict
Expert safety assessment and concern-level summary for Isatin.
Regulatory Flags
potential-allergen
colorant
eu_cosing_listed
Frequently Asked Questions
Is Isatin allowed in the EU?
Isatin EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Isatin do in cosmetics?
Isatin functions as: Hair colorant (oxidative and non-oxidative hair dye, up to 1.6% on-head). It is classified as a cosmetic ingredient in our database. CAS number: 91-56-5 [^1_1].
Compliance Tools
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Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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