Regulatory Status
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Safety Data
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Expert Verdict
Extreme sensitizer in GPMT; clastogenic in vitro (CHO chromosome aberration positive); negative in vivo micronucleus and UDS; teratogenic effects at 500 mg/kg/day (NOAEL 150 mg/kg/day developmental); stains skin orange/red
Regulatory Flags
Frequently Asked Questions
Is Isatin safe in cosmetics?
Extreme sensitizer in GPMT; clastogenic in vitro (CHO chromosome aberration positive); negative in vivo micronucleus and UDS; teratogenic effects at 500 mg/kg/day (NOAEL 150 mg/kg/day developmental); stains skin orange/red The EU classifies Isatin as "prohibited". Safety rating: MODERATE.
Is Isatin allowed in the EU?
Isatin EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Isatin do in cosmetics?
Isatin functions as: Hair colorant (oxidative and non-oxidative hair dye, up to 1.6% on-head). It is classified as a cosmetic ingredient in our database. CAS number: 91-56-5 [^1_1].
What is the Margin of Safety for Isatin?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
Compliance Tools
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Related Ingredients
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