Is Isoamyl Propionate safe in cosmetics?
Isoamyl Propionate has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
Isoamyl Propionate
Also known as: BRN 1747359, EINECS 203-322-1, FEMA No. 2082, Isoamyl propanoate, NSC 7932 (+13 more)
INCI: ISOAMYL PROPIONATE
Isoamyl Propionate (CAS 105-68-0) is a cosmetic cosmetic ingredient functioning as Fragrance ingredient; flavoring agent. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 105-68-0 →
Auto-generated CPSR Part A draft with source citations
Function
Fragrance ingredient; flavoring agent
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
3-methylbutyl propanoate
InChIKey
XAOGXQMKWQFZEM-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — FEMA GRAS (No. 2069); 21 CFR 172.515 indirect references to isoamyl esters
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Isoamyl Propionate.
Calculate MoS for your specific formulation with the MoS Calculator.
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 2700 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (2)
JECFA Number
44
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
ISOAMYL PROPIONATE | 1996 | No safety concern at current levels of intake when used as a flavouring agent | TRS 868-JECFA 46/23 | See TRS 868-JECFA 46/68
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (3)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Isoamyl Propionate.
Regulatory Flags
fragrance-component
ifra_fragrance
fda_food_additive
jecfa_safe
Known Synonyms
BRN 1747359
EINECS 203-322-1
FEMA No. 2082
Isoamyl propanoate
NSC 7932
UNII-2A8739M82Z
1-Butanol, 3-methyl-, 1-propanoate
1-Butanol, 3-methyl-, propanoate
3-Methyl-1-butyl propanoate
3-methylbutyl propionate
Dioleyl maleate
FEMA 2082
Iso-amyl N-propionate
Iso-pentyl propionate
Isopentyl alcohol, propionate
Propionic acid, isopentyl ester
isopentyl propanoate
isopentyl propionate
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
Europe
IFRA Transparency
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
consumer_product
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Isoamyl Propionate allowed in the EU?
Isoamyl Propionate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Isoamyl Propionate do in cosmetics?
Isoamyl Propionate functions as: Fragrance ingredient; flavoring agent. It is classified as a cosmetic ingredient in our database. CAS number: 105-68-0.
Is Isoamyl Propionate used outside cosmetics?
Isoamyl Propionate also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Isoamyl Propionate compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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