Isocetyl Ethylhexanoate

INCI: ISOCETYL ETHYLHEXANOATE

CAS Number
125804-19-5
Function
Skin conditioning agent — emollient
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Permitted — CIR Alkyl Ethylhexanoates: safe in present practices of use when formulated to be non-irritating

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Metabolite 2-ethylhexanoic acid is a liver/developmental toxicant at high oral doses in rodents; dermal route provides clearance that prevents toxic accumulation; may enhance penetration of co-formulated actives.

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Concern Level: Low

Frequently Asked Questions

Is Isocetyl Ethylhexanoate safe in cosmetics?

Metabolite 2-ethylhexanoic acid is a liver/developmental toxicant at high oral doses in rodents; dermal route provides clearance that prevents toxic accumulation; may enhance penetration of co-formulated actives. The EU classifies Isocetyl Ethylhexanoate as "permitted". Safety rating: GOOD.

Is Isocetyl Ethylhexanoate allowed in the EU?

Isocetyl Ethylhexanoate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Isocetyl Ethylhexanoate do in cosmetics?

Isocetyl Ethylhexanoate functions as: Skin conditioning agent — emollient. It is classified as a cosmetic ingredient in our database. CAS number: 125804-19-5.

What is the Margin of Safety for Isocetyl Ethylhexanoate?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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