NOAEL Studies Fragrance

Isoeugenol NOAEL Studies

INCI: ISOEUGENOL

CAS: 97-54-1

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

Back to parent ingredient page
COSMOS_DB 5 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS_DB NOAEL 70 mg/kg bw/day rat oral NA Multigeneration Reproductive US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 500 mg/kg bw/day rat oral 14 day Developmental US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 528 mg/kg bw/day rat oral 28 day Reproductive US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 800 mg/kg bw/day rat oral 14 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 1000 mg/kg bw/day rat oral 112 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx LOAEL =75 mg/kg bw/day Mouse - 730 days chronic/long term toxicity EFSA FEEDAP - 2012 - OutputID 149 - histopathology neoplastic - hepatotoxicity - Scientific Opinion on the safety and efficacy of propenylhydroxybenzenes (chemical group 17) when used as flavourings for all animal species - doi:10.2903/j.efsa.2012.2532
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx LOAEL =75 mg/kg bw/day Mouse - 730 days chronic/long term toxicity EFSA FEEDAP - 2012 - OutputID 149 - histopathology neoplastic - hepatotoxicity - Scientific Opinion on the safety and efficacy of propenylhydroxybenzenes (chemical group 17) when used as flavourings for all animal species - doi:10.2903/j.efsa.2012.2532
EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx ADI =75 µg/kg bw/day Consumers - - ADI EFSA FEEDAP - 2012 - OutputID 149 - Consumers - Scientific Opinion on the safety and efficacy of propenylhydroxybenzenes (chemical group 17) when used as flavourings for all animal species - doi:10.2903/j.efsa.2012.2532
EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx ADI =75 µg/kg bw/day Consumers - - ADI EFSA FEEDAP - 2012 - OutputID 149 - Consumers - Scientific Opinion on the safety and efficacy of propenylhydroxybenzenes (chemical group 17) when used as flavourings for all animal species - doi:10.2903/j.efsa.2012.2532
IARC Monographs 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
IARC Monographs IARC carcinogenicity classification 2B IARC group - - 2023 IARC Monographs {"additional_info":"volume_publication_year=2024","evaluation_year":2023,"source_table":"iarc_classifications","volume":"134"}
INCHEM_WHO_jecfa_jecmono_v52je17 8 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
INCHEM_WHO_jecfa_jecmono_v52je17 NOEL =6 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v52je17; title=HYDROXYPROPENYLBENZENES (addendum) (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je17.htm; row_hash=777c01e43c125778; raw_unit=mg/kg bw per day; context=The NOEL of 6 mg/kg bw per day for isoeugenol methyl ether (Osborne, 1981) is >1000 times greater than the daily intakes of 2 mg/kg bw per day in Europe and the USA as a flavouring agent See note 5 No safety concern Isoeugenyl ethyl ether 1267 7784-67-0 No Europe:
INCHEM_WHO_jecfa_jecmono_v52je17 NOEL =6 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v52je17; title=HYDROXYPROPENYLBENZENES (addendum) (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je17.htm; row_hash=777c01e43c125778; raw_unit=mg/kg bw per day; context=The NOEL of 6 mg/kg bw per day for isoeugenol methyl ether (Osborne, 1981) is >1000 times greater than the daily intakes of 2 mg/kg bw per day in Europe and the USA as a flavouring agent See note 5 No safety concern Isoeugenyl ethyl ether 1267 7784-67-0 No Europe:
INCHEM_WHO_jecfa_jecmono_v52je17 NOEL =100 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v52je17; title=HYDROXYPROPENYLBENZENES (addendum) (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je17.htm; row_hash=95f95fa9f19458fe; raw_unit=mg/kg bw per day; context=A NOEL of 100 mg/kg bw per day for isoeugenyl methylether (No.
INCHEM_WHO_jecfa_jecmono_v52je17 NOEL =100 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v52je17; title=HYDROXYPROPENYLBENZENES (addendum) (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je17.htm; row_hash=95f95fa9f19458fe; raw_unit=mg/kg bw per day; context=A NOEL of 100 mg/kg bw per day for isoeugenyl methylether (No.
INCHEM_WHO_jecfa_jecmono_v52je17 NOEL <250 mg/kg bw/day - - - Developmental toxicity document_id=jecfa_jecmono_v52je17; title=HYDROXYPROPENYLBENZENES (addendum) (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je17.htm; row_hash=7a7dbcd55b3555ae; raw_unit=mg/kg bw per day; context=The NOEL for propenylguaethol for maternal reproductive effects was <250 mg/kg bw per day, and the NOEL for developmental effects was reported as >2500 mg/kg bw per day (Hoberman, 1990).
INCHEM_WHO_jecfa_jecmono_v52je17 NOEL <250 mg/kg bw/day - - - Developmental toxicity document_id=jecfa_jecmono_v52je17; title=HYDROXYPROPENYLBENZENES (addendum) (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je17.htm; row_hash=7a7dbcd55b3555ae; raw_unit=mg/kg bw per day; context=The NOEL for propenylguaethol for maternal reproductive effects was <250 mg/kg bw per day, and the NOEL for developmental effects was reported as >2500 mg/kg bw per day (Hoberman, 1990).
INCHEM_WHO_jecfa_jecmono_v52je17 NOEL >2500 mg/kg bw/day - - - Developmental toxicity document_id=jecfa_jecmono_v52je17; title=HYDROXYPROPENYLBENZENES (addendum) (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je17.htm; row_hash=9bce7bd22c20c39f; raw_unit=mg/kg bw per day; context=The NOEL for propenylguaethol for maternal reproductive effects was <250 mg/kg bw per day, and the NOEL for developmental effects was reported as >2500 mg/kg bw per day (Hoberman, 1990).
INCHEM_WHO_jecfa_jecmono_v52je17 NOEL >2500 mg/kg bw/day - - - Developmental toxicity document_id=jecfa_jecmono_v52je17; title=HYDROXYPROPENYLBENZENES (addendum) (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je17.htm; row_hash=9bce7bd22c20c39f; raw_unit=mg/kg bw per day; context=The NOEL for propenylguaethol for maternal reproductive effects was <250 mg/kg bw per day, and the NOEL for developmental effects was reported as >2500 mg/kg bw per day (Hoberman, 1990).
NTP_ICE_acute_oral 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 =1560 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_11848; row=11770; data_type=In Vivo; mixture=Chemical; chemical_name=Isoeugenol; preferred_name=Isoeugenol; dtxsid=DTXSID7022413; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID7022413; source_file=acute_oral.xlsx
NTP_ICE_adme_parameters 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_adme_parameters Clint 71.78 uL/min/10^6 cells Human - - Measured; httk, Human Hepatic Intrinsic Clearance sheet=Data; excel_row=2783; Record_ID=adme_parameters_392; Data_Type=Measured; DTXSID=DTXSID7022413; Assay=httk, Human Hepatic Intrinsic Clearance; Endpoint=Clint; Response=71.78; Response_Unit=ul/min/10^6 cells; Species=Human; Reference=httk2.3.1, Wetmore 2015; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_adme_parameters Fu 0 fraction Human - - Measured; httk, Human Plasma Fraction Unbound sheet=Data; excel_row=2782; Record_ID=adme_parameters_392; Data_Type=Measured; DTXSID=DTXSID7022413; Assay=httk, Human Plasma Fraction Unbound; Endpoint=Fu; Response=0.0; Response_Unit=Unitless Fraction; Species=Human; Reference=httk2.3.1, Wetmore 2015; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_cancer 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_cancer POLY-3 lowest dose 75 mg/kg bw/day Mouse Gavage - In Vivo; Two year cancer bioassay sheet=Data; excel_row=8033; Record_ID=cancer_5289; Data_Type=In Vivo; Formulation_Name=Isoeugenol; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=Two year cancer bioassay; Endpoint=POLY-3 lowest dose; Response=75; Response_Unit=mg/kg/day; Species=Mouse; Strain=B6C3F1/N; Sex=Male; Route=Gavage; Level_of_Evidence=Clear evidence; Tissue=Liver; Lesion=Hepatocellular carcinoma or hepatocellular adenoma; Reference=TR-551; URL=https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr551/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_cancer Top dose 300 mg/kg Mouse Gavage - In Vivo; NTP Carcinogenicity sheet=Data; excel_row=8026; Record_ID=cancer_5292; Data_Type=In Vivo; Formulation_Name=Isoeugenol; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=300; Response_Unit=mg/kg; Species=Mouse; Strain=B6C3F1/N; Sex=Female; Route=Gavage; Reference=TR-551; URL=https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr551/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_dart 6 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_dart LOEL 250 mg/kg bw/day Rat Oral - In Vivo; DART, In life observation sheet=Data; excel_row=104786; Record_ID=dart_11285; Data_Type=In Vivo; DTXSID=DTXSID7022413; Assay=DART, In life observation; Endpoint=LOEL; Response=250; Response_Unit=mg/kg/day; Species=Rat; Strain=Sprague Dawley (CD); Sex=Female; Life_Stage=Adult; Route=Oral; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C3540840;CUI;Sign or Symptom|UMLS;C0278133;CUI;Rooting reflex; Reference=ToxRefDB v2 , ID = 5401; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_dart LOEL 250 mg/kg bw/day Rat Oral - In Vivo; DART, In life observation sheet=Data; excel_row=104787; Record_ID=dart_11286; Data_Type=In Vivo; DTXSID=DTXSID7022413; Assay=DART, In life observation; Endpoint=LOEL; Response=250; Response_Unit=mg/kg/day; Species=Rat; Strain=Sprague Dawley (CD); Sex=Female; Life_Stage=Adult; Route=Oral; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C3540840;CUI;Sign or Symptom|UMLS;C0278133;CUI;Rooting reflex; Reference=ToxRefDB v2 , ID = 5401; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_dart LOEL 250 mg/kg bw/day Rat Oral - In Vivo; DART, In life observation sheet=Data; excel_row=104788; Record_ID=dart_11287; Data_Type=In Vivo; DTXSID=DTXSID7022413; Assay=DART, In life observation; Endpoint=LOEL; Response=250; Response_Unit=mg/kg/day; Species=Rat; Strain=Sprague Dawley (CD); Sex=Female; Life_Stage=Adult; Route=Oral; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C0005910;CUI;Body Weight|UMLS;C3540840;CUI;Sign or Symptom|UMLS;C0005910;CUI;Body Weight; Reference=ToxRefDB v2 , ID = 5401; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_dart LOEL 250 mg/kg bw/day Rat Oral - In Vivo; DART, In life observation sheet=Data; excel_row=104789; Record_ID=dart_11288; Data_Type=In Vivo; DTXSID=DTXSID7022413; Assay=DART, In life observation; Endpoint=LOEL; Response=250; Response_Unit=mg/kg/day; Species=Rat; Strain=Sprague Dawley (CD); Sex=Female; Life_Stage=Adult; Route=Oral; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C0005910;CUI;Body Weight|UMLS;C3540840;CUI;Sign or Symptom|UMLS;C0043094;CUI;Weight Gain; Reference=ToxRefDB v2 , ID = 5401; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_dart LOEL 1000 mg/kg bw/day Rat Oral - In Vivo; DART, Developmental malformation sheet=Data; excel_row=104806; Record_ID=dart_11426; Data_Type=In Vivo; DTXSID=DTXSID7022413; Assay=DART, Developmental malformation; Endpoint=LOEL; Response=1000; Response_Unit=mg/kg/day; Species=Rat; Strain=Sprague Dawley (CD); Sex=Male/Female; Life_Stage=Fetal; Route=Oral; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C0000768;CUI;Congenital Abnormality|UMLS;C0265509;CUI;Congenital anomaly of skeletal bone|UMLS;C4086922;CUI;Unossified; Reference=ToxRefDB v2 , ID = 5401; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_dart LOEL 1000 mg/kg bw/day Rat Oral - In Vivo; DART, In life observation sheet=Data; excel_row=104807; Record_ID=dart_11425; Data_Type=In Vivo; DTXSID=DTXSID7022413; Assay=DART, In life observation; Endpoint=LOEL; Response=1000; Response_Unit=mg/kg/day; Species=Rat; Strain=Sprague Dawley (CD); Sex=Male/Female; Life_Stage=Fetal; Route=Oral; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C0005910;CUI;Body Weight|UMLS;C3540840;CUI;Sign or Symptom|UMLS;C0751992;CUI;Fetal Weight; Reference=ToxRefDB v2 , ID = 5401; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_endocrine 5 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_endocrine AC50 56.0165711806361 uM - - - ERPathway2016; ER Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=10712; RecordID=ERPathway2016_377; DatasetName=ERPathway2016; DTXSID=DTXSID7022413; Assay=ER Pathway Model, Antagonist; Endpoint=AC50; Response=56.0165711806361; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_endocrine ACC 48.2923742954896 uM - - - ERPathway2016; ER Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=10713; RecordID=ERPathway2016_377; DatasetName=ERPathway2016; DTXSID=DTXSID7022413; Assay=ER Pathway Model, Antagonist; Endpoint=ACC; Response=48.2923742954896; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_endocrine Model Score 0 unitless - - - ARPathway2016; AR Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=10708; RecordID=ARPathway2016_1789; DatasetName=ARPathway2016; DTXSID=DTXSID7022413; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_endocrine Model Score 0.0124 unitless - - - ERPathway2016; ER Pathway Model, Agonist sheet=Integrated_approaches; excel_row=10714; RecordID=ERPathway2016_377; DatasetName=ERPathway2016; DTXSID=DTXSID7022413; Assay=ER Pathway Model, Agonist; Endpoint=Model Score; Response=0.0124; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_endocrine Model Score 0.00199 unitless - - - ERPathway2016; ER Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=10715; RecordID=ERPathway2016_377; DatasetName=ERPathway2016; DTXSID=DTXSID7022413; Assay=ER Pathway Model, Antagonist; Endpoint=Model Score; Response=0.00199; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization 189 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_skin_sensitization CD86, EC150 17 ug/mL - Dermal - In Vitro; hCLAT2015; h-CLAT sheet=Data_invitro; excel_row=2874; Record_ID=skin_sensitization_invitro_670; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=h-CLAT; Endpoint=CD86, EC150; Reported_Response=17; Reported_Response_Unit=ug/mL; Response=17; Response_Unit=ug/mL; Reference=Bauch et al. 2011; 21669280; 10.1016/j.tiv.2011.05.030|Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization CD86, EC150 15 ug/mL - Dermal - In Vitro; Urbisch_SkinSensitization2020; U-SENS sheet=Data_invitro; excel_row=8275; Record_ID=skin_sensitization_invitro_2295; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=U-SENS; Endpoint=CD86, EC150; Reported_Response=91.35200974; Reported_Response_Unit=uM; Conversion_Factor_Value=164.204; Conversion_Factor_Source=EPA Dashboard; Converted_Response=15; Converted_Response_Unit=ug/mL; Response=15; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization CD86, EC150 44.76 ug/mL - Dermal - In Vitro; CE_USENSE2018; U-SENS sheet=Data_invitro; excel_row=8532; Record_ID=skin_sensitization_invitro_2352; Data_Type=In Vitro; Internal_Data_Source=CE_USENSE2018; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=U-SENS; Endpoint=CD86, EC150; Reported_Response=44.76; Reported_Response_Unit=ug/mL; Response=44.76; Response_Unit=ug/mL; Reference=Piroird et al. 2015; 25820135; 10.1016/j.tiv.2015.03.009; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization CV70 115.29 ug/mL - Dermal - In Vitro; CE_USENSE2018; U-SENS sheet=Data_invitro; excel_row=8530; Record_ID=skin_sensitization_invitro_2352; Data_Type=In Vitro; Internal_Data_Source=CE_USENSE2018; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=U-SENS; Endpoint=CV70; Reported_Response=115.29; Reported_Response_Unit=ug/mL; Response=115.29; Response_Unit=ug/mL; Reference=Piroird et al. 2015; 25820135; 10.1016/j.tiv.2015.03.009; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization CV75 112.5 ug/mL - Dermal - In Vitro; CE_hCLAT2018; h-CLAT sheet=Data_invitro; excel_row=2023; Record_ID=skin_sensitization_invitro_507; Data_Type=In Vitro; Internal_Data_Source=CE_hCLAT2018; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=h-CLAT; Endpoint=CV75; Reported_Response=112.5; Reported_Response_Unit=ug/mL; Response=112.5; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization CV75 48.3 ug/mL - Dermal - In Vitro; hCLAT2015; h-CLAT sheet=Data_invitro; excel_row=2875; Record_ID=skin_sensitization_invitro_670; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=h-CLAT; Endpoint=CV75; Reported_Response=48.3; Reported_Response_Unit=ug/mL; Response=48.3; Response_Unit=ug/mL; Reference=Bauch et al. 2011; 21669280; 10.1016/j.tiv.2011.05.030|Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization Concentration, 5% incidence of positive responses 3.244 % Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=11476; Record_ID=skin_sensitization_invivo_2491; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=8.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=Human Repeat Insult Patch Test; Endpoint=Concentration, 5% incidence of positive responses; Response=3.244; Response_Unit=%; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1980; 7441083; Not available|SCCNFP 1999; https://ec.europa.eu/health/archive/ph_risk/committees/sccp/documents/out93_en.pdf|Akkan et al. 2003; Not available; Not available|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization Concentration, one positive response 0.8889 % Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=11471; Record_ID=skin_sensitization_invivo_2491; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=8.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=Human Repeat Insult Patch Test; Endpoint=Concentration, one positive response; Response=0.8889; Response_Unit=%; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1980; 7441083; Not available|SCCNFP 1999; https://ec.europa.eu/health/archive/ph_risk/committees/sccp/documents/out93_en.pdf|Akkan et al. 2003; Not available; Not available|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization Depletion Cys 99.1 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=618; Record_ID=skin_sensitization_invitro_178; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=99.1; Reported_Response_Unit=%; Response=99.1; Response_Unit=%; Reference=Bauch et al. 2011; 21669280; 10.1016/j.tiv.2011.05.030|Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization Depletion Cys 89.3 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=622; Record_ID=skin_sensitization_invitro_179; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=89.3; Reported_Response_Unit=%; Response=89.3; Response_Unit=%; Reference=Jaworska 2011; 23670904; 10.1002/jat.2869|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization Depletion Cys 55.8 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=626; Record_ID=skin_sensitization_invitro_180; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=55.8; Reported_Response_Unit=%; Response=55.8; Response_Unit=%; Reference=Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006|Nukada personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization Depletion Lys 21.8 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=617; Record_ID=skin_sensitization_invitro_178; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=21.8; Reported_Response_Unit=%; Response=21.8; Response_Unit=%; Reference=Bauch et al. 2011; 21669280; 10.1016/j.tiv.2011.05.030|Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization Depletion Lys 10.7 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=621; Record_ID=skin_sensitization_invitro_179; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=10.7; Reported_Response_Unit=%; Response=10.7; Response_Unit=%; Reference=Jaworska 2011; 23670904; 10.1002/jat.2869|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization Depletion Lys 12.6 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=625; Record_ID=skin_sensitization_invitro_180; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=12.6; Reported_Response_Unit=%; Response=12.6; Response_Unit=%; Reference=Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006|Nukada personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization Depletion Lys + Cys 60.45 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=619; Record_ID=skin_sensitization_invitro_178; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=60.45; Reported_Response_Unit=%; Response=60.45; Response_Unit=%; Reference=Bauch et al. 2011; 21669280; 10.1016/j.tiv.2011.05.030|Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization Depletion Lys + Cys 50 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=623; Record_ID=skin_sensitization_invitro_179; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=50; Reported_Response_Unit=%; Response=50; Response_Unit=%; Reference=Jaworska 2011; 23670904; 10.1002/jat.2869|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization Depletion Lys + Cys 34 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=627; Record_ID=skin_sensitization_invitro_180; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=34; Reported_Response_Unit=%; Response=34; Response_Unit=%; Reference=Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006|Nukada personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization EC1.5 10.29 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=7306; Record_ID=skin_sensitization_invitro_1739; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=10.29; Reported_Response_Unit=uM; Response=10.29; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization EC1.5 10.4 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=7308; Record_ID=skin_sensitization_invitro_1753; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=10.4; Reported_Response_Unit=uM; Response=10.4; Response_Unit=uM; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization EC1.5 12.1 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=7309; Record_ID=skin_sensitization_invitro_1748; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=12.1; Reported_Response_Unit=uM; Response=12.1; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization EC1.5 13.42 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=7310; Record_ID=skin_sensitization_invitro_1736; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=13.42; Reported_Response_Unit=uM; Response=13.42; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization EC1.5 14.3 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=7311; Record_ID=skin_sensitization_invitro_1747; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=14.3; Reported_Response_Unit=uM; Response=14.3; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization EC1.5 14.4 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=7313; Record_ID=skin_sensitization_invitro_1746; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=14.4; Reported_Response_Unit=uM; Response=14.4; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization EC1.5 14.62 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=7314; Record_ID=skin_sensitization_invitro_1737; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=14.62; Reported_Response_Unit=uM; Response=14.62; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization EC1.5 15.2 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=7316; Record_ID=skin_sensitization_invitro_1731; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=15.2; Reported_Response_Unit=uM; Response=15.2; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization EC1.5 15.27 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=7317; Record_ID=skin_sensitization_invitro_1735; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=15.27; Reported_Response_Unit=uM; Response=15.27; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization EC1.5 16.064 uM - Dermal - In Vitro; CE_KeratinoSense2018; KeratinoSens sheet=Data_invitro; excel_row=7318; Record_ID=skin_sensitization_invitro_1729; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=16.064; Reported_Response_Unit=uM; Response=16.064; Response_Unit=uM; Reference=Emter et al. 2010; 20307559; 10.1016/j.taap.2010.03.009|Natsch et al. 2013; 23576290; 10.1002/jat.2868|Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization EC1.5 17.05 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=7319; Record_ID=skin_sensitization_invitro_1742; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=17.05; Reported_Response_Unit=uM; Response=17.05; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization EC1.5 17.4 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=7320; Record_ID=skin_sensitization_invitro_1750; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=17.399999999999999; Reported_Response_Unit=uM; Response=17.4; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization EC1.5 18.4 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=7321; Record_ID=skin_sensitization_invitro_1751; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=18.399999999999999; Reported_Response_Unit=uM; Response=18.4; Response_Unit=uM; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization EC1.5 19.34 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=7323; Record_ID=skin_sensitization_invitro_1744; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=19.34; Reported_Response_Unit=uM; Response=19.34; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization EC1.5 2.86 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=7324; Record_ID=skin_sensitization_invitro_1741; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=2.86; Reported_Response_Unit=uM; Response=2.86; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization EC1.5 20.4 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=7325; Record_ID=skin_sensitization_invitro_1732; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=20.399999999999999; Reported_Response_Unit=uM; Response=20.4; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization EC1.5 22.9 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=7326; Record_ID=skin_sensitization_invitro_1755; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=22.9; Reported_Response_Unit=uM; Response=22.9; Response_Unit=uM; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization EC1.5 23.3 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=7328; Record_ID=skin_sensitization_invitro_1752; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=23.3; Reported_Response_Unit=uM; Response=23.3; Response_Unit=uM; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization EC1.5 29.4 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=7329; Record_ID=skin_sensitization_invitro_1749; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=29.4; Reported_Response_Unit=uM; Response=29.4; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization EC1.5 3 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=7330; Record_ID=skin_sensitization_invitro_1740; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=3; Reported_Response_Unit=uM; Response=3; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization EC1.5 35.58 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=7332; Record_ID=skin_sensitization_invitro_1734; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=35.58; Reported_Response_Unit=uM; Response=35.58; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization EC1.5 36.21 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=7333; Record_ID=skin_sensitization_invitro_1745; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=36.21; Reported_Response_Unit=uM; Response=36.21; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization EC1.5 4.5 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=7334; Record_ID=skin_sensitization_invitro_1754; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=4.5; Reported_Response_Unit=uM; Response=4.5; Response_Unit=uM; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization EC1.5 5.73 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=7335; Record_ID=skin_sensitization_invitro_1738; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=5.73; Reported_Response_Unit=uM; Response=5.73; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization EC1.5 562.39 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=7337; Record_ID=skin_sensitization_invitro_1733; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=562.39; Reported_Response_Unit=uM; Response=562.39; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization EC1.5 6 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=7338; Record_ID=skin_sensitization_invitro_1730; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=6; Reported_Response_Unit=uM; Response=6; Response_Unit=uM; Reference=Bauch et al. 2011; 21669280; 10.1016/j.tiv.2011.05.030|Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization EC1.5 <120.56 uM - Dermal - In Vitro; Urbisch_SkinSensitization2020; LuSens sheet=Data_invitro; excel_row=7605; Record_ID=skin_sensitization_invitro_1844; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=LuSens; Endpoint=EC1.5; Response_Modifier=<; Reported_Response_Modifier=<; Reported_Response=120.56; Reported_Response_Unit=uM; Response=120.56; Response_Unit=uM; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization EC3 259.4 uM - Dermal - In Vitro; CE_KeratinoSense2018; KeratinoSens sheet=Data_invitro; excel_row=7339; Record_ID=skin_sensitization_invitro_1729; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=KeratinoSens; Endpoint=EC3; Reported_Response=259.42899999999997; Reported_Response_Unit=uM; Response=259.4; Response_Unit=uM; Reference=Emter et al. 2010; 20307559; 10.1016/j.taap.2010.03.009|Natsch et al. 2013; 23576290; 10.1002/jat.2868|Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization EC3 1.5 % Mouse Dermal - In Vivo; LLNA2013; LLNA sheet=Data_invivo; excel_row=12843; Record_ID=skin_sensitization_invivo_481; Data_Type=In Vivo; Internal_Data_Source=LLNA2013; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=LLNA; Endpoint=EC3; Response=1.5; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=ICCVAM 2009; Not available; https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-ps/llnaperfstds.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization EC3 2.6 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13347; Record_ID=skin_sensitization_invivo_3471; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=LLNA; Endpoint=EC3; Response=2.6; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Basketter and Cadby 2004; 15059097; 10.1111/j.0105-1873.2004.00278.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization EC3 2 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13349; Record_ID=skin_sensitization_invivo_3473; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=LLNA; Endpoint=EC3; Response=2; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Basketter and Cadby 2004; 15059097; 10.1111/j.0105-1873.2004.00278.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization EC3 0.8 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13351; Record_ID=skin_sensitization_invivo_3476; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=LLNA; Endpoint=EC3; Response=0.8; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Basketter and Cadby 2004; 15059097; 10.1111/j.0105-1873.2004.00278.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization EC3 0.6 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13352; Record_ID=skin_sensitization_invivo_3478; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=LLNA; Endpoint=EC3; Response=0.6; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Basketter and Cadby 2004; 15059097; 10.1111/j.0105-1873.2004.00278.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization EC3 1.4 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13353; Record_ID=skin_sensitization_invivo_3479; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=LLNA; Endpoint=EC3; Response=1.4; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Basketter and Cadby 2004; 15059097; 10.1111/j.0105-1873.2004.00278.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization EC3 1.6 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13354; Record_ID=skin_sensitization_invivo_3480; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=LLNA; Endpoint=EC3; Response=1.6; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Basketter and Cadby 2004; 15059097; 10.1111/j.0105-1873.2004.00278.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization EC3 1.3 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13366; Record_ID=skin_sensitization_invivo_3493; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=LLNA; Endpoint=EC3; Response=1.3; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Kimber et al. 1991; 1998208; 10.1016/0378-4274(91)90135-s; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization EC3 2.2 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13369; Record_ID=skin_sensitization_invivo_3498; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=LLNA; Endpoint=EC3; Response=2.2; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Kimber et al. 1991; 1998208; 10.1016/0378-4274(91)90135-s; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization EC3 1 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13372; Record_ID=skin_sensitization_invivo_3502; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=LLNA; Endpoint=EC3; Response=1; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Basketter and Cadby 2004; 15059097; 10.1111/j.0105-1873.2004.00278.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization EC3 3.3 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13376; Record_ID=skin_sensitization_invivo_3506; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=LLNA; Endpoint=EC3; Response=3.3; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Loveless et al. 1996; 8644112; 10.1016/0300-483x(95)03279-o; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization EC3 1.1 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13377; Record_ID=skin_sensitization_invivo_3507; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=LLNA; Endpoint=EC3; Response=1.1; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Basketter and Cadby 2004; 15059097; 10.1111/j.0105-1873.2004.00278.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization EC3 2.1 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13378; Record_ID=skin_sensitization_invivo_3508; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=LLNA; Endpoint=EC3; Response=2.1; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Basketter and Cadby 2004; 15059097; 10.1111/j.0105-1873.2004.00278.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization EC3 1.8 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13379; Record_ID=skin_sensitization_invivo_3509; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=LLNA; Endpoint=EC3; Response=1.8; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Loveless et al. 1996; 8644112; 10.1016/0300-483x(95)03279-o; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization EC3 0.5 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13381; Record_ID=skin_sensitization_invivo_3511; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=LLNA; Endpoint=EC3; Response=0.5; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Basketter and Cadby 2004; 15059097; 10.1111/j.0105-1873.2004.00278.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization EC3 3.1 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13382; Record_ID=skin_sensitization_invivo_3512; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=LLNA; Endpoint=EC3; Response=3.1; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Loveless et al. 1996; 8644112; 10.1016/0300-483x(95)03279-o; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization EC3 1.9 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13383; Record_ID=skin_sensitization_invivo_3513; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=LLNA; Endpoint=EC3; Response=1.9; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Basketter and Cadby 2004; 15059097; 10.1111/j.0105-1873.2004.00278.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization EC3 1.2 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13385; Record_ID=skin_sensitization_invivo_3515; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=LLNA; Endpoint=EC3; Response=1.2; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Gerberick et al. 2005; 16536334; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization EC3 0.9 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13389; Record_ID=skin_sensitization_invivo_3519; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=LLNA; Endpoint=EC3; Response=0.9; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Wright et al. 2001; 18498452; 10.1046/j.1467-2494.2001.00066.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization EC3 5 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13393; Record_ID=skin_sensitization_invivo_3523; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=LLNA; Endpoint=EC3; Response=5; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Wright et al. 2001; 18498452; 10.1046/j.1467-2494.2001.00066.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization EC3 0.7 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13395; Record_ID=skin_sensitization_invivo_3525; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=LLNA; Endpoint=EC3; Response=0.7; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Basketter and Cadby 2004; 15059097; 10.1111/j.0105-1873.2004.00278.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization EC3 2.5 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13398; Record_ID=skin_sensitization_invivo_3528; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=LLNA; Endpoint=EC3; Response=2.5; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Wright et al. 2001; 18498452; 10.1046/j.1467-2494.2001.00066.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization EC3 2.6 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13347; Record_ID=skin_sensitization_invivo_3471; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=LLNA; Endpoint=EC3; Response=2.6; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Basketter and Cadby 2004; 15059097; 10.1111/j.0105-1873.2004.00278.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization EC3 2 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13349; Record_ID=skin_sensitization_invivo_3473; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=LLNA; Endpoint=EC3; Response=2; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Basketter and Cadby 2004; 15059097; 10.1111/j.0105-1873.2004.00278.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization EC3 0.8 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13351; Record_ID=skin_sensitization_invivo_3476; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=LLNA; Endpoint=EC3; Response=0.8; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Basketter and Cadby 2004; 15059097; 10.1111/j.0105-1873.2004.00278.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization EC3 0.6 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13352; Record_ID=skin_sensitization_invivo_3478; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=LLNA; Endpoint=EC3; Response=0.6; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Basketter and Cadby 2004; 15059097; 10.1111/j.0105-1873.2004.00278.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization EC3 1.4 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13353; Record_ID=skin_sensitization_invivo_3479; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=LLNA; Endpoint=EC3; Response=1.4; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Basketter and Cadby 2004; 15059097; 10.1111/j.0105-1873.2004.00278.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization EC3 1.6 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13354; Record_ID=skin_sensitization_invivo_3480; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=LLNA; Endpoint=EC3; Response=1.6; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Basketter and Cadby 2004; 15059097; 10.1111/j.0105-1873.2004.00278.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization EC3 1.3 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13366; Record_ID=skin_sensitization_invivo_3493; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=LLNA; Endpoint=EC3; Response=1.3; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Kimber et al. 1991; 1998208; 10.1016/0378-4274(91)90135-s; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization EC3 2.2 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13369; Record_ID=skin_sensitization_invivo_3498; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=LLNA; Endpoint=EC3; Response=2.2; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Kimber et al. 1991; 1998208; 10.1016/0378-4274(91)90135-s; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization EC3 1 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13372; Record_ID=skin_sensitization_invivo_3502; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=LLNA; Endpoint=EC3; Response=1; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Basketter and Cadby 2004; 15059097; 10.1111/j.0105-1873.2004.00278.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization EC3 3.3 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13376; Record_ID=skin_sensitization_invivo_3506; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=LLNA; Endpoint=EC3; Response=3.3; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Loveless et al. 1996; 8644112; 10.1016/0300-483x(95)03279-o; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization EC3 1.1 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13377; Record_ID=skin_sensitization_invivo_3507; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=LLNA; Endpoint=EC3; Response=1.1; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Basketter and Cadby 2004; 15059097; 10.1111/j.0105-1873.2004.00278.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization EC3 2.1 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13378; Record_ID=skin_sensitization_invivo_3508; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=LLNA; Endpoint=EC3; Response=2.1; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Basketter and Cadby 2004; 15059097; 10.1111/j.0105-1873.2004.00278.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization EC3 1.8 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13379; Record_ID=skin_sensitization_invivo_3509; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=LLNA; Endpoint=EC3; Response=1.8; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Loveless et al. 1996; 8644112; 10.1016/0300-483x(95)03279-o; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization EC3 0.5 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13381; Record_ID=skin_sensitization_invivo_3511; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=LLNA; Endpoint=EC3; Response=0.5; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Basketter and Cadby 2004; 15059097; 10.1111/j.0105-1873.2004.00278.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization EC3 3.1 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13382; Record_ID=skin_sensitization_invivo_3512; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=LLNA; Endpoint=EC3; Response=3.1; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Loveless et al. 1996; 8644112; 10.1016/0300-483x(95)03279-o; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization EC3 1.9 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13383; Record_ID=skin_sensitization_invivo_3513; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=LLNA; Endpoint=EC3; Response=1.9; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Basketter and Cadby 2004; 15059097; 10.1111/j.0105-1873.2004.00278.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization EC3 1.2 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13385; Record_ID=skin_sensitization_invivo_3515; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=LLNA; Endpoint=EC3; Response=1.2; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Gerberick et al. 2005; 16536334; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization EC3 0.9 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13389; Record_ID=skin_sensitization_invivo_3519; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=LLNA; Endpoint=EC3; Response=0.9; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Wright et al. 2001; 18498452; 10.1046/j.1467-2494.2001.00066.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization EC3 5 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13393; Record_ID=skin_sensitization_invivo_3523; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=LLNA; Endpoint=EC3; Response=5; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Wright et al. 2001; 18498452; 10.1046/j.1467-2494.2001.00066.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization EC3 0.7 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13395; Record_ID=skin_sensitization_invivo_3525; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=LLNA; Endpoint=EC3; Response=0.7; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Basketter and Cadby 2004; 15059097; 10.1111/j.0105-1873.2004.00278.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization EC3 2.5 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13398; Record_ID=skin_sensitization_invivo_3528; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=LLNA; Endpoint=EC3; Response=2.5; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Wright et al. 2001; 18498452; 10.1046/j.1467-2494.2001.00066.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization EC3 2.6 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13347; Record_ID=skin_sensitization_invivo_3471; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=LLNA; Endpoint=EC3; Response=2.6; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Basketter and Cadby 2004; 15059097; 10.1111/j.0105-1873.2004.00278.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization EC3 2 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13349; Record_ID=skin_sensitization_invivo_3473; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=LLNA; Endpoint=EC3; Response=2; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Basketter and Cadby 2004; 15059097; 10.1111/j.0105-1873.2004.00278.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization EC3 0.8 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13351; Record_ID=skin_sensitization_invivo_3476; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=LLNA; Endpoint=EC3; Response=0.8; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Basketter and Cadby 2004; 15059097; 10.1111/j.0105-1873.2004.00278.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization EC3 0.6 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13352; Record_ID=skin_sensitization_invivo_3478; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=LLNA; Endpoint=EC3; Response=0.6; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Basketter and Cadby 2004; 15059097; 10.1111/j.0105-1873.2004.00278.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization EC3 1.4 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13353; Record_ID=skin_sensitization_invivo_3479; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=LLNA; Endpoint=EC3; Response=1.4; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Basketter and Cadby 2004; 15059097; 10.1111/j.0105-1873.2004.00278.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization EC3 1.6 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13354; Record_ID=skin_sensitization_invivo_3480; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=LLNA; Endpoint=EC3; Response=1.6; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Basketter and Cadby 2004; 15059097; 10.1111/j.0105-1873.2004.00278.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization EC3 1.3 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13366; Record_ID=skin_sensitization_invivo_3493; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=LLNA; Endpoint=EC3; Response=1.3; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Kimber et al. 1991; 1998208; 10.1016/0378-4274(91)90135-s; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization EC3 2.2 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13369; Record_ID=skin_sensitization_invivo_3498; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=LLNA; Endpoint=EC3; Response=2.2; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Kimber et al. 1991; 1998208; 10.1016/0378-4274(91)90135-s; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization EC3 1 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13372; Record_ID=skin_sensitization_invivo_3502; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=LLNA; Endpoint=EC3; Response=1; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Basketter and Cadby 2004; 15059097; 10.1111/j.0105-1873.2004.00278.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization EC3 3.3 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13376; Record_ID=skin_sensitization_invivo_3506; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=LLNA; Endpoint=EC3; Response=3.3; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Loveless et al. 1996; 8644112; 10.1016/0300-483x(95)03279-o; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization EC3 1.1 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13377; Record_ID=skin_sensitization_invivo_3507; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=LLNA; Endpoint=EC3; Response=1.1; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Basketter and Cadby 2004; 15059097; 10.1111/j.0105-1873.2004.00278.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization EC3 2.1 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13378; Record_ID=skin_sensitization_invivo_3508; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=LLNA; Endpoint=EC3; Response=2.1; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Basketter and Cadby 2004; 15059097; 10.1111/j.0105-1873.2004.00278.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization EC3 1.8 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13379; Record_ID=skin_sensitization_invivo_3509; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=LLNA; Endpoint=EC3; Response=1.8; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Loveless et al. 1996; 8644112; 10.1016/0300-483x(95)03279-o; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization EC3 0.5 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13381; Record_ID=skin_sensitization_invivo_3511; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=LLNA; Endpoint=EC3; Response=0.5; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Basketter and Cadby 2004; 15059097; 10.1111/j.0105-1873.2004.00278.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization EC3 3.1 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13382; Record_ID=skin_sensitization_invivo_3512; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=LLNA; Endpoint=EC3; Response=3.1; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Loveless et al. 1996; 8644112; 10.1016/0300-483x(95)03279-o; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization EC3 1.9 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13383; Record_ID=skin_sensitization_invivo_3513; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=LLNA; Endpoint=EC3; Response=1.9; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Basketter and Cadby 2004; 15059097; 10.1111/j.0105-1873.2004.00278.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization EC3 1.2 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13385; Record_ID=skin_sensitization_invivo_3515; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=LLNA; Endpoint=EC3; Response=1.2; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Gerberick et al. 2005; 16536334; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization EC3 0.9 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13389; Record_ID=skin_sensitization_invivo_3519; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=LLNA; Endpoint=EC3; Response=0.9; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Wright et al. 2001; 18498452; 10.1046/j.1467-2494.2001.00066.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization EC3 5 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13393; Record_ID=skin_sensitization_invivo_3523; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=LLNA; Endpoint=EC3; Response=5; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Wright et al. 2001; 18498452; 10.1046/j.1467-2494.2001.00066.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization EC3 0.7 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13395; Record_ID=skin_sensitization_invivo_3525; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=LLNA; Endpoint=EC3; Response=0.7; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Basketter and Cadby 2004; 15059097; 10.1111/j.0105-1873.2004.00278.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization EC3 2.5 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13398; Record_ID=skin_sensitization_invivo_3528; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=LLNA; Endpoint=EC3; Response=2.5; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Wright et al. 2001; 18498452; 10.1046/j.1467-2494.2001.00066.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization EC3 2.6 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13347; Record_ID=skin_sensitization_invivo_3471; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=LLNA; Endpoint=EC3; Response=2.6; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Basketter and Cadby 2004; 15059097; 10.1111/j.0105-1873.2004.00278.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization EC3 2 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13349; Record_ID=skin_sensitization_invivo_3473; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=LLNA; Endpoint=EC3; Response=2; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Basketter and Cadby 2004; 15059097; 10.1111/j.0105-1873.2004.00278.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization EC3 0.8 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13351; Record_ID=skin_sensitization_invivo_3476; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=LLNA; Endpoint=EC3; Response=0.8; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Basketter and Cadby 2004; 15059097; 10.1111/j.0105-1873.2004.00278.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization EC3 0.6 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13352; Record_ID=skin_sensitization_invivo_3478; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=LLNA; Endpoint=EC3; Response=0.6; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Basketter and Cadby 2004; 15059097; 10.1111/j.0105-1873.2004.00278.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization EC3 1.4 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13353; Record_ID=skin_sensitization_invivo_3479; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=LLNA; Endpoint=EC3; Response=1.4; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Basketter and Cadby 2004; 15059097; 10.1111/j.0105-1873.2004.00278.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization EC3 1.6 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13354; Record_ID=skin_sensitization_invivo_3480; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=LLNA; Endpoint=EC3; Response=1.6; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Basketter and Cadby 2004; 15059097; 10.1111/j.0105-1873.2004.00278.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization EC3 1.3 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13366; Record_ID=skin_sensitization_invivo_3493; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=LLNA; Endpoint=EC3; Response=1.3; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Kimber et al. 1991; 1998208; 10.1016/0378-4274(91)90135-s; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization EC3 2.2 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13369; Record_ID=skin_sensitization_invivo_3498; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=LLNA; Endpoint=EC3; Response=2.2; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Kimber et al. 1991; 1998208; 10.1016/0378-4274(91)90135-s; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization EC3 1 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13372; Record_ID=skin_sensitization_invivo_3502; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=LLNA; Endpoint=EC3; Response=1; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Basketter and Cadby 2004; 15059097; 10.1111/j.0105-1873.2004.00278.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization EC3 3.3 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13376; Record_ID=skin_sensitization_invivo_3506; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=LLNA; Endpoint=EC3; Response=3.3; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Loveless et al. 1996; 8644112; 10.1016/0300-483x(95)03279-o; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization EC3 1.1 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13377; Record_ID=skin_sensitization_invivo_3507; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=LLNA; Endpoint=EC3; Response=1.1; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Basketter and Cadby 2004; 15059097; 10.1111/j.0105-1873.2004.00278.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization EC3 2.1 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13378; Record_ID=skin_sensitization_invivo_3508; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=LLNA; Endpoint=EC3; Response=2.1; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Basketter and Cadby 2004; 15059097; 10.1111/j.0105-1873.2004.00278.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization EC3 1.8 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13379; Record_ID=skin_sensitization_invivo_3509; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=LLNA; Endpoint=EC3; Response=1.8; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Loveless et al. 1996; 8644112; 10.1016/0300-483x(95)03279-o; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization EC3 0.5 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13381; Record_ID=skin_sensitization_invivo_3511; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=LLNA; Endpoint=EC3; Response=0.5; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Basketter and Cadby 2004; 15059097; 10.1111/j.0105-1873.2004.00278.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization EC3 3.1 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13382; Record_ID=skin_sensitization_invivo_3512; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=LLNA; Endpoint=EC3; Response=3.1; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Loveless et al. 1996; 8644112; 10.1016/0300-483x(95)03279-o; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization EC3 1.9 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13383; Record_ID=skin_sensitization_invivo_3513; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=LLNA; Endpoint=EC3; Response=1.9; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Basketter and Cadby 2004; 15059097; 10.1111/j.0105-1873.2004.00278.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization EC3 1.2 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13385; Record_ID=skin_sensitization_invivo_3515; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=LLNA; Endpoint=EC3; Response=1.2; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Gerberick et al. 2005; 16536334; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization EC3 0.9 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13389; Record_ID=skin_sensitization_invivo_3519; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=LLNA; Endpoint=EC3; Response=0.9; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Wright et al. 2001; 18498452; 10.1046/j.1467-2494.2001.00066.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization EC3 5 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13393; Record_ID=skin_sensitization_invivo_3523; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=LLNA; Endpoint=EC3; Response=5; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Wright et al. 2001; 18498452; 10.1046/j.1467-2494.2001.00066.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization EC3 0.7 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13395; Record_ID=skin_sensitization_invivo_3525; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=LLNA; Endpoint=EC3; Response=0.7; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Basketter and Cadby 2004; 15059097; 10.1111/j.0105-1873.2004.00278.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization EC3 2.5 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13398; Record_ID=skin_sensitization_invivo_3528; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=LLNA; Endpoint=EC3; Response=2.5; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Wright et al. 2001; 18498452; 10.1046/j.1467-2494.2001.00066.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization IC50 1521 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=7341; Record_ID=skin_sensitization_invitro_1738; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=1521; Reported_Response_Unit=uM; Response=1521; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization IC50 248.47 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=7342; Record_ID=skin_sensitization_invitro_1733; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=248.47; Reported_Response_Unit=uM; Response=248.47; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization IC50 393.62 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=7343; Record_ID=skin_sensitization_invitro_1742; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=393.62; Reported_Response_Unit=uM; Response=393.62; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization IC50 474.89 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=7344; Record_ID=skin_sensitization_invitro_1748; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=474.89; Reported_Response_Unit=uM; Response=474.89; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization IC50 479.57 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=7346; Record_ID=skin_sensitization_invitro_1744; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=479.57; Reported_Response_Unit=uM; Response=479.57; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization IC50 515.7 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=7347; Record_ID=skin_sensitization_invitro_1755; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=515.70000000000005; Reported_Response_Unit=uM; Response=515.7; Response_Unit=uM; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization IC50 540.11 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=7348; Record_ID=skin_sensitization_invitro_1749; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=540.11; Reported_Response_Unit=uM; Response=540.11; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization IC50 550.9 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=7349; Record_ID=skin_sensitization_invitro_1751; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=550.9; Reported_Response_Unit=uM; Response=550.9; Response_Unit=uM; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization IC50 560.6 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=7350; Record_ID=skin_sensitization_invitro_1752; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=560.6; Reported_Response_Unit=uM; Response=560.6; Response_Unit=uM; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization IC50 652 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=7351; Record_ID=skin_sensitization_invitro_1750; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=651.95000000000005; Reported_Response_Unit=uM; Response=652; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization IC50 704.7 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=7353; Record_ID=skin_sensitization_invitro_1739; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=704.7; Reported_Response_Unit=uM; Response=704.7; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization IC50 719.3 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=7354; Record_ID=skin_sensitization_invitro_1730; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=719.3; Reported_Response_Unit=uM; Response=719.3; Response_Unit=uM; Reference=Bauch et al. 2011; 21669280; 10.1016/j.tiv.2011.05.030|Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization IC50 726.73 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=7355; Record_ID=skin_sensitization_invitro_1745; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=726.73; Reported_Response_Unit=uM; Response=726.73; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization IC50 731.37 uM - Dermal - In Vitro; CE_KeratinoSense2018; KeratinoSens sheet=Data_invitro; excel_row=7356; Record_ID=skin_sensitization_invitro_1729; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=731.37; Reported_Response_Unit=uM; Response=731.37; Response_Unit=uM; Reference=Emter et al. 2010; 20307559; 10.1016/j.taap.2010.03.009|Natsch et al. 2013; 23576290; 10.1002/jat.2868|Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization IC50 777.64 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=7358; Record_ID=skin_sensitization_invitro_1741; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=777.64; Reported_Response_Unit=uM; Response=777.64; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization IC50 791.6 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=7359; Record_ID=skin_sensitization_invitro_1754; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=791.6; Reported_Response_Unit=uM; Response=791.6; Response_Unit=uM; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization IC50 794.81 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=7360; Record_ID=skin_sensitization_invitro_1735; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=794.81; Reported_Response_Unit=uM; Response=794.81; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization IC50 805.25 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=7361; Record_ID=skin_sensitization_invitro_1737; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=805.25; Reported_Response_Unit=uM; Response=805.25; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization IC50 810.42 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=7363; Record_ID=skin_sensitization_invitro_1736; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=810.42; Reported_Response_Unit=uM; Response=810.42; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization IC50 891.9 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=7364; Record_ID=skin_sensitization_invitro_1734; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=891.9; Reported_Response_Unit=uM; Response=891.9; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization IC50 905.34 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=7365; Record_ID=skin_sensitization_invitro_1740; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=905.34; Reported_Response_Unit=uM; Response=905.34; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization IC50 997.5 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=7366; Record_ID=skin_sensitization_invitro_1753; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=997.5; Reported_Response_Unit=uM; Response=997.5; Response_Unit=uM; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization IC50 >300 uM - Dermal - In Vitro; Urbisch_SkinSensitization2020; LuSens sheet=Data_invitro; excel_row=7675; Record_ID=skin_sensitization_invitro_1844; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=LuSens; Endpoint=IC50; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=300; Reported_Response_Unit=uM; Response=300; Response_Unit=uM; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization Imax 11.324 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=7367; Record_ID=skin_sensitization_invitro_1734; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=11.324; Reported_Response_Unit=Unitless; Response=11.324; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization Imax 11.651 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=7369; Record_ID=skin_sensitization_invitro_1745; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=11.651; Reported_Response_Unit=Unitless; Response=11.651; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization Imax 12.23 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=7370; Record_ID=skin_sensitization_invitro_1750; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=12.234999999999999; Reported_Response_Unit=Unitless; Response=12.23; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization Imax 13.2 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=7371; Record_ID=skin_sensitization_invitro_1751; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=13.2; Reported_Response_Unit=Unitless; Response=13.2; Response_Unit=Ratio; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization Imax 30.599 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=7389; Record_ID=skin_sensitization_invitro_1737; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=30.599; Reported_Response_Unit=Unitless; Response=30.599; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization Imax 31.41 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=7390; Record_ID=skin_sensitization_invitro_1738; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=31.411999999999999; Reported_Response_Unit=Unitless; Response=31.41; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization Imax 42.506 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=7391; Record_ID=skin_sensitization_invitro_1739; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=42.506; Reported_Response_Unit=Unitless; Response=42.506; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization Imax 5.517 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=7392; Record_ID=skin_sensitization_invitro_1731; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=5.5170000000000003; Reported_Response_Unit=Unitless; Response=5.517; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization Imax 5.687 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=7393; Record_ID=skin_sensitization_invitro_1742; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=5.6870000000000003; Reported_Response_Unit=Unitless; Response=5.687; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization Imax 175 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=7394; Record_ID=skin_sensitization_invitro_1730; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=175; Reported_Response_Unit=Unitless; Response=175; Response_Unit=Ratio; Reference=Bauch et al. 2011; 21669280; 10.1016/j.tiv.2011.05.030|Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization Imax 19.279 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=7395; Record_ID=skin_sensitization_invitro_1748; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=19.279; Reported_Response_Unit=Unitless; Response=19.279; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization Imax 56.8 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=7396; Record_ID=skin_sensitization_invitro_1754; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=56.8; Reported_Response_Unit=Unitless; Response=56.8; Response_Unit=Ratio; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization Imax 23.2 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=7397; Record_ID=skin_sensitization_invitro_1753; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=23.2; Reported_Response_Unit=Unitless; Response=23.2; Response_Unit=Ratio; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization Imax 25.8 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=7398; Record_ID=skin_sensitization_invitro_1744; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=25.800999999999998; Reported_Response_Unit=Unitless; Response=25.8; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization Imax 29.84 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=7399; Record_ID=skin_sensitization_invitro_1741; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=29.838999999999999; Reported_Response_Unit=Unitless; Response=29.84; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization Imax 6.208 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=7400; Record_ID=skin_sensitization_invitro_1747; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=6.2080000000000002; Reported_Response_Unit=Unitless; Response=6.208; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization Imax 6.338 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=7401; Record_ID=skin_sensitization_invitro_1733; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=6.3380000000000001; Reported_Response_Unit=Unitless; Response=6.338; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization Imax 6.41 ratio - Dermal - In Vitro; CE_KeratinoSense2018; KeratinoSens sheet=Data_invitro; excel_row=7403; Record_ID=skin_sensitization_invitro_1729; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=6.41; Reported_Response_Unit=Unitless; Response=6.41; Response_Unit=Ratio; Reference=Emter et al. 2010; 20307559; 10.1016/j.taap.2010.03.009|Natsch et al. 2013; 23576290; 10.1002/jat.2868|Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization Imax 62.67 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=7407; Record_ID=skin_sensitization_invitro_1746; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=62.674999999999997; Reported_Response_Unit=Unitless; Response=62.67; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization Imax 7.509 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=7411; Record_ID=skin_sensitization_invitro_1732; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=7.5090000000000003; Reported_Response_Unit=Unitless; Response=7.509; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization Imax 7.651 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=7415; Record_ID=skin_sensitization_invitro_1735; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=7.6509999999999998; Reported_Response_Unit=Unitless; Response=7.651; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization Imax 7.67 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=7421; Record_ID=skin_sensitization_invitro_1736; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=7.67; Reported_Response_Unit=Unitless; Response=7.67; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization Imax 8.076 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=7426; Record_ID=skin_sensitization_invitro_1749; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=8.0760000000000005; Reported_Response_Unit=Unitless; Response=8.076; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization Imax 9.5 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=7431; Record_ID=skin_sensitization_invitro_1752; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=9.5; Reported_Response_Unit=Unitless; Response=9.5; Response_Unit=Ratio; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization Imax 98.05 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=7436; Record_ID=skin_sensitization_invitro_1740; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=98.052999999999997; Reported_Response_Unit=Unitless; Response=98.05; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization Imax 25.41 ratio - Dermal - In Vitro; Urbisch_SkinSensitization2020; LuSens sheet=Data_invitro; excel_row=7578; Record_ID=skin_sensitization_invitro_1844; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=LuSens; Endpoint=Imax; Reported_Response=25.41289236; Reported_Response_Unit=Unitless; Response=25.41; Response_Unit=Ratio; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization Incidence of positive responses 0 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=11451; Record_ID=skin_sensitization_invivo_2488; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=8.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1971: report to RIFM|Opdyke 1975; Not available; 10.1016/0015-6264(75)90234-5|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization Incidence of positive responses 12.33 % Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=11468; Record_ID=skin_sensitization_invivo_2491; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=8.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=Human Repeat Insult Patch Test; Endpoint=Incidence of positive responses; Response=12.33; Response_Unit=%; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1980; 7441083; Not available|SCCNFP 1999; https://ec.europa.eu/health/archive/ph_risk/committees/sccp/documents/out93_en.pdf|Akkan et al. 2003; Not available; Not available|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization Induction dose per skin area 5184 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=11449; Record_ID=skin_sensitization_invivo_2488; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=8.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=5184; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1971: report to RIFM|Opdyke 1975; Not available; 10.1016/0015-6264(75)90234-5|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization Induction dose per skin area 250 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=11457; Record_ID=skin_sensitization_invivo_2490; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.5; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=250; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 1980; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Basketter et al. 2005; 16283904; 10.1111/j.0105-1873.2005.00707.x|Api et al. 2008; 18406028; 10.1016/j.yrtph.2007.10.008|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization Induction dose per skin area 5039 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=11466; Record_ID=skin_sensitization_invivo_2491; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=8.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=5039; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1980; 7441083; Not available|SCCNFP 1999; https://ec.europa.eu/health/archive/ph_risk/committees/sccp/documents/out93_en.pdf|Akkan et al. 2003; Not available; Not available|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization Induction dose per skin area, 5% incidence of positive responses 2044 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=11478; Record_ID=skin_sensitization_invivo_2491; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=8.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area, 5% incidence of positive responses; Response=2044; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1980; 7441083; Not available|SCCNFP 1999; https://ec.europa.eu/health/archive/ph_risk/committees/sccp/documents/out93_en.pdf|Akkan et al. 2003; Not available; Not available|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization Induction dose per skin area, one positive response 559.9 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=11473; Record_ID=skin_sensitization_invivo_2491; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=8.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area, one positive response; Response=559.9; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1980; 7441083; Not available|SCCNFP 1999; https://ec.europa.eu/health/archive/ph_risk/committees/sccp/documents/out93_en.pdf|Akkan et al. 2003; Not available; Not available|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization Max stimulation index 31 ratio Mouse Dermal - In Vivo; LLNA2013; LLNA sheet=Data_invivo; excel_row=12842; Record_ID=skin_sensitization_invivo_481; Data_Type=In Vivo; Internal_Data_Source=LLNA2013; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=LLNA; Endpoint=Max stimulation index; Response=31; Response_Unit=Ratio; Species=Mouse; Route=Dermal; Reference=ICCVAM 2009; Not available; https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-ps/llnaperfstds.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization Relative reliability score 3 unitless Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=11455; Record_ID=skin_sensitization_invivo_2488; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=8.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Kligman 1971: report to RIFM|Opdyke 1975; Not available; 10.1016/0015-6264(75)90234-5|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
NTP_ICE_skin_sensitization Relative reliability score 2 unitless Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=11480; Record_ID=skin_sensitization_invivo_2491; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=8.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7022413; Assay=Human Repeat Insult Patch Test; Endpoint=Relative reliability score; Response=2; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1980; 7441083; Not available|SCCNFP 1999; https://ec.europa.eu/health/archive/ph_risk/committees/sccp/documents/out93_en.pdf|Akkan et al. 2003; Not available; Not available|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022413; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7022413
ToxRefDB_ToxRefDB_v3_pod.csv 12 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxRefDB_ToxRefDB_v3_pod.csv LEL =150 mg/kg bw/day rat (fischer; Fischer 344) oral 0 week to 14 week SUB study_id=5440; toxval_study_source_id=studyid5440_Adult_F0_F_systemic; toxval_effect_list=clinical chemistry-[other]-[other]|pathology microscopic-liver-cytoplasmic alteration|pathology microscopic-nose-atrophy|organ weight-liver-absolute|organ weight-liver-relative to body weight|organ weight-kidney-absolute|organ weight-kidney-relative to body weight; dose_level=3; study_year=2010; study_citation=NTP_2010_NTP Technical Report on the Toxicology and Carcinogenesis Studies of Isoeugenol (CAS No. 97-54-1) in F344/N Rats and B6C2F1 Mice (Gavage Studies)_14-week study_Rats; dsstox_substance_id=DTXSID7022413; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
ToxRefDB_ToxRefDB_v3_pod.csv LEL =600 mg/kg bw/day mouse (b6c3f1; B6C3F1) oral 0 week to 14 week SUB study_id=5441; toxval_study_source_id=studyid5441_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-nose-atrophy|organ weight-lung-absolute; dose_level=5; study_year=2010; study_citation=NTP_2010_NTP Technical Report on the Toxicology and Carcinogenesis Studies of Isoeugenol (CAS No. 97-54-1) in F344/N Rats and B6C2F1 Mice (Gavage Studies)_14-week study_Mice; dsstox_substance_id=DTXSID7022413; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
ToxRefDB_ToxRefDB_v3_pod.csv LEL =37.5 mg/kg bw/day mouse (b6c3f1; B6C3F1) oral 0 week to 14 week SUB study_id=5441; toxval_study_source_id=studyid5441_Adult_F0_M_systemic; toxval_effect_list=organ weight-liver-relative to body weight|organ weight-kidney-absolute|organ weight-liver-absolute|in life observation-body weight-body weight gain|pathology microscopic-nose-atrophy|in life observation-body weight-body weight; dose_level=1; study_year=2010; study_citation=NTP_2010_NTP Technical Report on the Toxicology and Carcinogenesis Studies of Isoeugenol (CAS No. 97-54-1) in F344/N Rats and B6C2F1 Mice (Gavage Studies)_14-week study_Mice; dsstox_substance_id=DTXSID7022413; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
ToxRefDB_ToxRefDB_v3_pod.csv LEL =300 mg/kg bw/day rat (fischer; Fischer 344) oral 0 week to 105 week CHR study_id=5442; toxval_study_source_id=studyid5442_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-nose-atrophy|pathology microscopic-nose-metaplasia; dose_level=3; study_year=2010; study_citation=NTP_2010_NTP Technical Report on the Toxicology and Carcinogenesis Studies of Isoeugenol (CAS No. 97-54-1) in F344/N Rats and B6C2F1 Mice (Gavage Studies)_2-year study_Rats; dsstox_substance_id=DTXSID7022413; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
ToxRefDB_ToxRefDB_v3_pod.csv LEL =75 mg/kg bw/day rat (fischer; Fischer 344) oral 0 week to 105 week CHR study_id=5442; toxval_study_source_id=studyid5442_Adult_F0_M_systemic; toxval_effect_list=pathology microscopic-nose-metaplasia|pathology microscopic-nose-atrophy|pathology microscopic-thymus-thymoma nos|pathology microscopic-mammary gland-carcinoma|pathology microscopic-nose-degeneration; dose_level=1; study_year=2010; study_citation=NTP_2010_NTP Technical Report on the Toxicology and Carcinogenesis Studies of Isoeugenol (CAS No. 97-54-1) in F344/N Rats and B6C2F1 Mice (Gavage Studies)_2-year study_Rats; dsstox_substance_id=DTXSID7022413; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
ToxRefDB_ToxRefDB_v3_pod.csv LOAEL =600 mg/kg bw/day rat (fischer; Fischer 344) oral 0 week to 14 week SUB study_id=5440; toxval_study_source_id=studyid5440_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-nose-atrophy|pathology microscopic-liver-cytoplasmic alteration|organ weight-liver-absolute|organ weight-liver-relative to body weight; dose_level=5; study_year=2010; study_citation=NTP_2010_NTP Technical Report on the Toxicology and Carcinogenesis Studies of Isoeugenol (CAS No. 97-54-1) in F344/N Rats and B6C2F1 Mice (Gavage Studies)_14-week study_Rats; dsstox_substance_id=DTXSID7022413; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
ToxRefDB_ToxRefDB_v3_pod.csv NEL =75 mg/kg bw/day rat (fischer; Fischer 344) oral 0 week to 14 week SUB study_id=5440; toxval_study_source_id=studyid5440_Adult_F0_F_systemic; toxval_effect_list=organ weight-kidney-absolute|clinical chemistry-[other]-[other]|pathology microscopic-nose-atrophy|pathology microscopic-liver-cytoplasmic alteration|organ weight-kidney-relative to body weight|organ weight-liver-absolute|organ weight-liver-relative to body weight; dose_level=2; study_year=2010; study_citation=NTP_2010_NTP Technical Report on the Toxicology and Carcinogenesis Studies of Isoeugenol (CAS No. 97-54-1) in F344/N Rats and B6C2F1 Mice (Gavage Studies)_14-week study_Rats; dsstox_substance_id=DTXSID7022413; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
ToxRefDB_ToxRefDB_v3_pod.csv NEL =37.5 mg/kg bw/day rat (fischer; Fischer 344) oral 0 week to 14 week SUB study_id=5440; toxval_study_source_id=studyid5440_Adult_F0_M_systemic; toxval_effect_list=in life observation-body weight-body weight|in life observation-body weight-body weight gain|clinical chemistry-cytochrome p450, nos-cytochrome p450, nos|pathology microscopic-nose-atrophy; dose_level=1; study_year=2010; study_citation=NTP_2010_NTP Technical Report on the Toxicology and Carcinogenesis Studies of Isoeugenol (CAS No. 97-54-1) in F344/N Rats and B6C2F1 Mice (Gavage Studies)_14-week study_Rats; dsstox_substance_id=DTXSID7022413; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
ToxRefDB_ToxRefDB_v3_pod.csv NEL =300 mg/kg bw/day mouse (b6c3f1; B6C3F1) oral 0 week to 14 week SUB study_id=5441; toxval_study_source_id=studyid5441_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-nose-atrophy|organ weight-lung-absolute; dose_level=4; study_year=2010; study_citation=NTP_2010_NTP Technical Report on the Toxicology and Carcinogenesis Studies of Isoeugenol (CAS No. 97-54-1) in F344/N Rats and B6C2F1 Mice (Gavage Studies)_14-week study_Mice; dsstox_substance_id=DTXSID7022413; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
ToxRefDB_ToxRefDB_v3_pod.csv NEL >0 mg/kg bw/day mouse (b6c3f1; B6C3F1) oral 0 week to 14 week SUB study_id=5441; toxval_study_source_id=studyid5441_Adult_F0_M_systemic; toxval_effect_list=in life observation-body weight-body weight|pathology microscopic-nose-atrophy|organ weight-liver-absolute|organ weight-kidney-absolute|in life observation-body weight-body weight gain|organ weight-liver-relative to body weight; dose_level=0; study_year=2010; study_citation=NTP_2010_NTP Technical Report on the Toxicology and Carcinogenesis Studies of Isoeugenol (CAS No. 97-54-1) in F344/N Rats and B6C2F1 Mice (Gavage Studies)_14-week study_Mice; dsstox_substance_id=DTXSID7022413; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
ToxRefDB_ToxRefDB_v3_pod.csv NEL =150 mg/kg bw/day rat (fischer; Fischer 344) oral 0 week to 105 week CHR study_id=5442; toxval_study_source_id=studyid5442_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-nose-atrophy|pathology microscopic-nose-metaplasia; dose_level=2; study_year=2010; study_citation=NTP_2010_NTP Technical Report on the Toxicology and Carcinogenesis Studies of Isoeugenol (CAS No. 97-54-1) in F344/N Rats and B6C2F1 Mice (Gavage Studies)_2-year study_Rats; dsstox_substance_id=DTXSID7022413; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
ToxRefDB_ToxRefDB_v3_pod.csv NOAEL =300 mg/kg bw/day rat (fischer; Fischer 344) oral 0 week to 14 week SUB study_id=5440; toxval_study_source_id=studyid5440_Adult_F0_F_systemic; toxval_effect_list=clinical chemistry-[other]-[other]|organ weight-kidney-absolute|pathology microscopic-liver-cytoplasmic alteration|pathology microscopic-nose-atrophy|organ weight-liver-absolute|organ weight-kidney-relative to body weight|organ weight-liver-relative to body weight; dose_level=4; study_year=2010; study_citation=NTP_2010_NTP Technical Report on the Toxicology and Carcinogenesis Studies of Isoeugenol (CAS No. 97-54-1) in F344/N Rats and B6C2F1 Mice (Gavage Studies)_14-week study_Rats; dsstox_substance_id=DTXSID7022413; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
ToxValDB_ECHA_IUCLID 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID NOAEL =75 mg/kg bw/day Rat oral chronic; 14 weeks chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae7fe4b0a7c65d1c99e7; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/34499/7/6/2?documentUUID=c664dab6-36ff-4cc4-8d00-5af27c01d424; YEAR=2018; ORIGINAL_YEAR=2018; STUDY_GROUP=ECHA IUCLID:15849638:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_774f53f60b38390279579ddf46bcc2ed
ToxValDB_ECOTOX 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECOTOX LOEL =50 % v/v Mouse dermal short-term; 3 days short-term LONG_REF=Arch. Toxicol.74(12): 733-744 Ulrich,P., J. Streich, and W. Suter Intralaboratory Validation of Alternative Endpoints in the Murine Local Lymph Node Assay for the Identification of Contact Allergic Potential: Primary Ear Skin Irritation and Ear-Draining Lymph Node Hyperplasia Induced 2001; TITLE=Intralaboratory Validation of Alternative Endpoints in the Murine Local Lymph Node Assay for the Identification of Contact Allergic Potential: Primary Ear Skin Irritation and Ear-Draining Lymph Node Hyperplasia Induced; AUTHOR=Ulrich,P., J. Streich, and W. Suter; DOI=10.1007/s002040000192; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=112411; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2001; ORIGINAL_YEAR=2001; TOXICOLOGICAL_EFFECT=Morphology: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15598637_15598638_15598639_15598640:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=82a24dd5e3c75071886fb4e60d36a3b2
ToxValDB_ECOTOX LOEL =20 % v/v Mouse dermal short-term; 3 days short-term LONG_REF=Arch. Toxicol.74(12): 733-744 Ulrich,P., J. Streich, and W. Suter Intralaboratory Validation of Alternative Endpoints in the Murine Local Lymph Node Assay for the Identification of Contact Allergic Potential: Primary Ear Skin Irritation and Ear-Draining Lymph Node Hyperplasia Induced 2001; TITLE=Intralaboratory Validation of Alternative Endpoints in the Murine Local Lymph Node Assay for the Identification of Contact Allergic Potential: Primary Ear Skin Irritation and Ear-Draining Lymph Node Hyperplasia Induced; AUTHOR=Ulrich,P., J. Streich, and W. Suter; DOI=10.1007/s002040000192; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=112411; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2001; ORIGINAL_YEAR=2001; TOXICOLOGICAL_EFFECT=Cell(s): Number of cells; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECOTOX_dup_EPA ORD_15598637_15598638_15598639_15598640:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=082f396e2075f4cb55a9c7eb63396d24
ToxValDB_ECOTOX NOEL =1 % v/v Mouse dermal short-term; 3 days short-term LONG_REF=Arch. Toxicol.74(12): 733-744 Ulrich,P., J. Streich, and W. Suter Intralaboratory Validation of Alternative Endpoints in the Murine Local Lymph Node Assay for the Identification of Contact Allergic Potential: Primary Ear Skin Irritation and Ear-Draining Lymph Node Hyperplasia Induced 2001; TITLE=Intralaboratory Validation of Alternative Endpoints in the Murine Local Lymph Node Assay for the Identification of Contact Allergic Potential: Primary Ear Skin Irritation and Ear-Draining Lymph Node Hyperplasia Induced; AUTHOR=Ulrich,P., J. Streich, and W. Suter; DOI=10.1007/s002040000192; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=112411; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2001; ORIGINAL_YEAR=2001; TOXICOLOGICAL_EFFECT=Cell(s): Number of cells; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECOTOX_dup_EPA ORD_15598637_15598638_15598639_15598640:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=47a5d5ac7c17af0a323221315d993ac6
ToxValDB_EFSA 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_EFSA LOAEL =75 mg/kg bw/day Mouse oral chronic; 2 years chronic LONG_REF=EFSA FEEDAP (2012). Scientific Opinion on the safety and efficacy of propenylhydroxybenzenes (chemical group 17) when used as flavourings for all animal species. doi:10.2903/j.efsa.2012.2532.; TITLE=Scientific Opinion on the safety and efficacy of propenylhydroxybenzenes (chemical group 17) when used as flavourings for all animal species; AUTHOR=EFSA FEEDAP; DOI=doi:10.2903/j.efsa.2012.2532; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2012; ORIGINAL_YEAR=2012; TOXICOLOGICAL_EFFECT=histopathology: neoplastic; STUDY_GROUP=EFSA:15614067:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_59dd3bae211f3803312976f077e7caf2
ToxValDB_ToxRefDB 7 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ToxRefDB LEL =150 mg/kg bw/day Rat oral chronic; 14 weeks chronic LONG_REF=NTP_2010_NTP Technical Report on the Toxicology and Carcinogenesis Studies of Isoeugenol (CAS No. 97-54-1) in F344/N Rats and B6C2F1 Mice (Gavage Studies)_14-week study_Rats; TITLE=NTP Technical Report on the Toxicology and Carcinogenesis Studies of Isoeugenol (CAS No. 97-54-1) in F344/N Rats and B6C2F1 Mice (Gavage Studies)_14-week study_Rats; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5440; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2010; ORIGINAL_YEAR=2010; TOXICOLOGICAL_EFFECT=systemic: clinical chemistry-[other]-[other]|systemic: organ weight-liver-absolute|systemic: pathology microscopic-liver-cytoplasmic alteration|systemic: organ weight-liver-relative to body weight|systemic: pathology microscopic-nose-atrophy|systemic: organ weight-kidney-absolute|systemic: organ weight-kidney-relative to body weight; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|nonneoplastic histopathology|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15709238_15709239_15709240_15709241:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3f5c7f706d6744e736423de752d0eee3
ToxValDB_ToxRefDB LEL =600 mg/kg bw/day Mouse oral chronic; 14 weeks chronic LONG_REF=NTP_2010_NTP Technical Report on the Toxicology and Carcinogenesis Studies of Isoeugenol (CAS No. 97-54-1) in F344/N Rats and B6C2F1 Mice (Gavage Studies)_14-week study_Mice; TITLE=NTP Technical Report on the Toxicology and Carcinogenesis Studies of Isoeugenol (CAS No. 97-54-1) in F344/N Rats and B6C2F1 Mice (Gavage Studies)_14-week study_Mice; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5441; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2010; ORIGINAL_YEAR=2010; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-nose-atrophy|systemic: organ weight-lung-absolute; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15709246_15709247_15709248_15709249:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4cb6083b514977bc9f9e88325df15774
ToxValDB_ToxRefDB LEL =37.5 mg/kg bw/day Mouse oral chronic; 14 weeks chronic LONG_REF=NTP_2010_NTP Technical Report on the Toxicology and Carcinogenesis Studies of Isoeugenol (CAS No. 97-54-1) in F344/N Rats and B6C2F1 Mice (Gavage Studies)_14-week study_Mice; TITLE=NTP Technical Report on the Toxicology and Carcinogenesis Studies of Isoeugenol (CAS No. 97-54-1) in F344/N Rats and B6C2F1 Mice (Gavage Studies)_14-week study_Mice; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5441; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2010; ORIGINAL_YEAR=2010; TOXICOLOGICAL_EFFECT=systemic: organ weight-liver-relative to body weight|systemic: organ weight-kidney-absolute|systemic: organ weight-liver-absolute|systemic: in life observation-body weight-body weight gain|systemic: pathology microscopic-nose-atrophy|systemic: in life observation-body weight-body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|nonneoplastic histopathology|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15709250_15709251_15709252:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e0a5ed846f767281c46a2c3e6b448784
ToxValDB_ToxRefDB LOAEL =600 mg/kg bw/day Rat oral chronic; 14 weeks chronic LONG_REF=NTP_2010_NTP Technical Report on the Toxicology and Carcinogenesis Studies of Isoeugenol (CAS No. 97-54-1) in F344/N Rats and B6C2F1 Mice (Gavage Studies)_14-week study_Rats; TITLE=NTP Technical Report on the Toxicology and Carcinogenesis Studies of Isoeugenol (CAS No. 97-54-1) in F344/N Rats and B6C2F1 Mice (Gavage Studies)_14-week study_Rats; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5440; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2010; ORIGINAL_YEAR=2010; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-nose-atrophy|systemic: organ weight-liver-relative to body weight|systemic: organ weight-liver-absolute|systemic: pathology microscopic-liver-cytoplasmic alteration; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15709238_15709239_15709240_15709241:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_de5510214872bc9b88b93e78d526fba6
ToxValDB_ToxRefDB NEL =37.5 mg/kg bw/day Rat oral chronic; 14 weeks chronic LONG_REF=NTP_2010_NTP Technical Report on the Toxicology and Carcinogenesis Studies of Isoeugenol (CAS No. 97-54-1) in F344/N Rats and B6C2F1 Mice (Gavage Studies)_14-week study_Rats; TITLE=NTP Technical Report on the Toxicology and Carcinogenesis Studies of Isoeugenol (CAS No. 97-54-1) in F344/N Rats and B6C2F1 Mice (Gavage Studies)_14-week study_Rats; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5440; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2010; ORIGINAL_YEAR=2010; TOXICOLOGICAL_EFFECT=systemic: clinical chemistry-cytochrome p450, nos-cytochrome p450, nos|systemic: pathology microscopic-nose-atrophy|systemic: in life observation-body weight-body weight gain|systemic: in life observation-body weight-body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|multiple|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15709242_15709243_15709244_15709245:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1bb75a7454b3ac7be3f3521b96389ece
ToxValDB_ToxRefDB NEL =300 mg/kg bw/day Mouse oral chronic; 14 weeks chronic LONG_REF=NTP_2010_NTP Technical Report on the Toxicology and Carcinogenesis Studies of Isoeugenol (CAS No. 97-54-1) in F344/N Rats and B6C2F1 Mice (Gavage Studies)_14-week study_Mice; TITLE=NTP Technical Report on the Toxicology and Carcinogenesis Studies of Isoeugenol (CAS No. 97-54-1) in F344/N Rats and B6C2F1 Mice (Gavage Studies)_14-week study_Mice; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5441; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2010; ORIGINAL_YEAR=2010; TOXICOLOGICAL_EFFECT=systemic: organ weight-lung-absolute|systemic: pathology microscopic-nose-atrophy; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15709246_15709247_15709248_15709249:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e5fc18a49a3aa9a7d79b41bcaa0c03e6
ToxValDB_ToxRefDB NOAEL =300 mg/kg bw/day Rat oral chronic; 14 weeks chronic LONG_REF=NTP_2010_NTP Technical Report on the Toxicology and Carcinogenesis Studies of Isoeugenol (CAS No. 97-54-1) in F344/N Rats and B6C2F1 Mice (Gavage Studies)_14-week study_Rats; TITLE=NTP Technical Report on the Toxicology and Carcinogenesis Studies of Isoeugenol (CAS No. 97-54-1) in F344/N Rats and B6C2F1 Mice (Gavage Studies)_14-week study_Rats; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5440; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2010; ORIGINAL_YEAR=2010; TOXICOLOGICAL_EFFECT=systemic: organ weight-liver-absolute|systemic: organ weight-kidney-relative to body weight|systemic: pathology microscopic-liver-cytoplasmic alteration|systemic: clinical chemistry-[other]-[other]|systemic: organ weight-kidney-absolute|systemic: organ weight-liver-relative to body weight|systemic: pathology microscopic-nose-atrophy; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|nonneoplastic histopathology|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15709238_15709239_15709240_15709241:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_cb65d3820f6e94e1da780ecaf939505b
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 5M0MWY797U UNII - - - mixture {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"mixture","unii_code":"5M0MWY797U"}
openFDA substances FDA UNII substance identifier 5M0MWY797U UNII - - - mixture {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"mixture","unii_code":"5M0MWY797U"}
openFDA substances FDA UNII substance identifier 5M0MWY797U UNII - - - mixture {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"mixture","unii_code":"5M0MWY797U"}
openFDA substances FDA UNII substance identifier 5M0MWY797U UNII - - - mixture {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"mixture","unii_code":"5M0MWY797U"}