Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
7 study endpoints found for Isoeugenol. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 1000 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 500 mg/kg bw/day | oral | rat | Developmental | COSMOS_DB |
| NOAEL | 528 mg/kg bw/day | oral | rat | Reproductive | COSMOS_DB |
| NOAEL | 800 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 70 mg/kg bw/day | oral | rat | Multigeneration Reproductive | COSMOS_DB |
| dose_tested | 1000 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| dose_tested | 528 mg/kg bw/day | oral | rat | Reproductive | COSMOS_DB |
Sensitization Profile
Contact sensitization data for Isoeugenol based on clinical patch test studies and IFRA standards.
Source: ESSCA/IVDK
Dermal Penetration Profile
Skin absorption and penetration characteristics of Isoeugenol, relevant to systemic exposure and MoS calculations.
Source: SCCS/1459/11, IFRA
Expert Verdict
One of the most potent sensitizers among the EU 26 fragrance allergens with mandatory allergen labelling; very low use levels permissible and avoidance recommended in products for sensitized or compromised skin.
Regulatory Flags
Frequently Asked Questions
Is Isoeugenol safe in cosmetics?
One of the most potent sensitizers among the EU 26 fragrance allergens with mandatory allergen labelling; very low use levels permissible and avoidance recommended in products for sensitized or compromised skin. The EU classifies Isoeugenol as "restricted". Safety rating: POOR. 7 toxicological study endpoint(s) are available in our database.
Is Isoeugenol allowed in the EU?
Isoeugenol EU regulatory status: restricted. Maximum allowed concentration: >10 ppm leave-on / >100 ppm rinse-off. This is based on EU Regulation 1223/2009 and its amendments.
What does Isoeugenol do in cosmetics?
Isoeugenol functions as: fragrance. It is classified as a Fragrance in our database. CAS number: 97-54-1.
What is the Margin of Safety for Isoeugenol?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Isoeugenol?
The NOAEL (No Observed Adverse Effect Level) for Isoeugenol is 1000 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 7 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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