Laccase

CAS Number
80498-15-3
Function
Oxidizing agent
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted; no specific cosmetic restriction under 21 CFR

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
negligible
Sensitization
high

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Occupational respiratory sensitizer requiring engineering controls during manufacturing. Finished-product dermal risk is lower, but spray/aerosol application is contraindicated. Enzyme activity may cause substrate oxidation; ingredient compatibility must be verified.

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Concern Level: High

Regulatory Flags

potential-allergen

Frequently Asked Questions

Is Laccase safe in cosmetics?

Occupational respiratory sensitizer requiring engineering controls during manufacturing. Finished-product dermal risk is lower, but spray/aerosol application is contraindicated. Enzyme activity may cause substrate oxidation; ingredient compatibility must be verified. The EU classifies Laccase as "permitted". Safety rating: MODERATE.

Is Laccase allowed in the EU?

Laccase EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Laccase do in cosmetics?

Laccase functions as: Oxidizing agent. It is classified as a cosmetic ingredient in our database. CAS number: 80498-15-3.

What is the Margin of Safety for Laccase?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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