Lactoperoxidase

INCI: LACTOPEROXIDASE

CAS Number
9003-99-0
Function
Skin conditioning agent; antimicrobial enzyme for oral care and skin care applications
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted under 21 CFR 700; GRAS enzyme in food applications; considered safe as used in cosmetics

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
negligible
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Lactoperoxidase activity depends on substrate availability (H2O2 and thiocyanate system); bovine origin requires BSE/TSE compliance; enzyme stability must be validated in formulation; potential for milk protein allergy cross-reactivity should be considered.

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Concern Level: Low

Regulatory Flags

eu_children_restricted

Frequently Asked Questions

Is Lactoperoxidase safe in cosmetics?

Lactoperoxidase activity depends on substrate availability (H2O2 and thiocyanate system); bovine origin requires BSE/TSE compliance; enzyme stability must be validated in formulation; potential for milk protein allergy cross-reactivity should be considered. The EU classifies Lactoperoxidase as "permitted". Safety rating: GOOD.

Is Lactoperoxidase allowed in the EU?

Lactoperoxidase EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Lactoperoxidase do in cosmetics?

Lactoperoxidase functions as: Skin conditioning agent; antimicrobial enzyme for oral care and skin care applications. It is classified as a cosmetic ingredient in our database. CAS number: 9003-99-0.

What is the Margin of Safety for Lactoperoxidase?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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