Is Lactoperoxidase safe in cosmetics?
Lactoperoxidase has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
GOOD
Cosmetic Ingredient
Lactoperoxidase
INCI: LACTOPEROXIDASE
Lactoperoxidase (CAS 9003-99-0) is a cosmetic cosmetic ingredient functioning as Skin conditioning agent; antimicrobial enzyme for oral care and skin care. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and food safety data.
Cross-Vertical Regulatory Divergence
Lactoperoxidase is classified GHS Danger (H317, H334) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu status; Chemicals: ghs classifications.signal word/hazard statement code
Function
Skin conditioning agent; antimicrobial enzyme for oral care and skin care applications
Editorial assessment
GOOD
Preliminary editorial note — not a computed safety verdict.
Chemistry & Identifiers
IUPAC Name
N-(2-aminophenyl)-4-[[(4-pyridin-3-ylpyrimidin-2-yl)amino]methyl]benzamide
InChIKey
HRNLUBSXIHFDHP-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted under 21 CFR 700; GRAS enzyme in food applications; considered safe as used in cosmetics
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Lactoperoxidase.
Calculate MoS for your specific formulation with the MoS Calculator.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Antioxidant
Softener and conditioner
Stabilizing agent
Regulatory List Membership (1)
EU Restricted for Children (Cosmetics)
Editorial summary
Preliminary editorial summary for Lactoperoxidase — not a computed safety verdict. See the sourced toxicological data above.
Regulatory Flags
eu_children_restricted
Chemical Function
Antioxidant
Softener and conditioner
Stabilizing agent
Regulatory Lists
children; Europe; Personal care - dental care - toothpaste
children; Europe; Personal care
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in food safety data.
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
Lactoperoxidase
Food Category
preservative
Frequently Asked Questions
Is Lactoperoxidase allowed in the EU?
Lactoperoxidase EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Lactoperoxidase do in cosmetics?
Lactoperoxidase functions as: Skin conditioning agent; antimicrobial enzyme for oral care and skin care applications. It is classified as a cosmetic ingredient in our database. CAS number: 9003-99-0.
Is Lactoperoxidase used outside cosmetics?
Lactoperoxidase also appears in industrial chemical safety and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Lactoperoxidase have different safety status in cosmetics vs industrial chemicals?
Lactoperoxidase is classified GHS Danger (H317, H334) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Lactoperoxidase compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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