Moderate Surfactant NOAEL Data

Lauramidopropyl Betaine

INCI: LAURAMIDOPROPYL BETAINE

CAS Number
4292-10-8
Function
Amphoteric surfactant, foam booster, conditioning, viscosity controller
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes CIR safe when formulated to be nonsensitizing. Up to 13% rinse-off, 6% leave-on. DMAPA impurity must be controlled.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

6 study endpoints found for Lauramidopropyl Betaine. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOEL 247 mg/kg bw/day oral rat oral REACH
NOEL 300 mg/kg bw/day oral rat oral REACH
NOEL 300 mg/kg bw/day oral - oral REACH
NOEL 300 mg/kg bw/day oral rat oral REACH
NOEL 375 mg/kg bw/day oral rat oral REACH
NOAEL 300 mg/kg bw/day oral rat oral REACH

Expert Verdict

Mild amphoteric co-surfactant with sensitization risk from DMAPA and amidoamine synthesis residues; source from certified low-DMAPA suppliers.

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Concern Level: Low

Regulatory Flags

epa_safer_alternative

Frequently Asked Questions

Is Lauramidopropyl Betaine safe in cosmetics?

Mild amphoteric co-surfactant with sensitization risk from DMAPA and amidoamine synthesis residues; source from certified low-DMAPA suppliers. The EU classifies Lauramidopropyl Betaine as "permitted". Safety rating: MODERATE. 6 toxicological study endpoint(s) are available in our database.

Is Lauramidopropyl Betaine allowed in the EU?

Lauramidopropyl Betaine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Lauramidopropyl Betaine do in cosmetics?

Lauramidopropyl Betaine functions as: Amphoteric surfactant, foam booster, conditioning, viscosity controller. It is classified as a Surfactant in our database. CAS number: 4292-10-8.

What is the Margin of Safety for Lauramidopropyl Betaine?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Lauramidopropyl Betaine?

The NOAEL (No Observed Adverse Effect Level) for Lauramidopropyl Betaine is 247 mg/kg bw/day based on a oral study via oral route in rat. A total of 6 study endpoints are available. Source: REACH.

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