Moderate Cosmetic Ingredient NOAEL Data GHS Classified

Lauryl Alcohol

INCI: LAURYL ALCOHOL

CAS Number
112-53-8
Function
Emollient, emulsifier, viscosity controlling agent, fragrance ingredient
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted โ€” not restricted under 21 CFR; RIFM safety assessment completed (2025)

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

1 study endpoint found for Lauryl Alcohol. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 3324 mg/kg bw/day oral rat Special Toxicology Study COSMOS_DB

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Signal Word
WARNING
Pictograms
excl mark;warn; cancer;health haz; enviro;aqua
Hazard Statements
Causes skin and eye irritation May cause respiratory irritation May be harmful if swallowed and enters airways Very toxic to aquatic life with long lasting effects
Short-term Exposure Effects
The substance is irritating to the skin, eyes and possibly the respiratory tract. If swallowed the substance may cause vomiting and could result in aspiration pneumonitis.
Long-term Exposure Effects
See Notes.
Routes of Exposure
The substance can be absorbed into the body by inhalation, through the skin and by ingestion.

Expert Verdict

Eye irritant with aquatic toxicity concerns; environmental impact consideration for rinse-off products. Equivocal tumorigenic potential in animal studies with limited relevance to cosmetic use.

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Concern Level: Moderate

Regulatory Flags

fragrance-component epa_safer_alternative ifra_fragrance fda_food_additive jecfa_safe

Frequently Asked Questions

Is Lauryl Alcohol safe in cosmetics?

Eye irritant with aquatic toxicity concerns; environmental impact consideration for rinse-off products. Equivocal tumorigenic potential in animal studies with limited relevance to cosmetic use. The EU classifies Lauryl Alcohol as "permitted". Safety rating: MODERATE. 1 toxicological study endpoint(s) are available in our database.

Is Lauryl Alcohol allowed in the EU?

Lauryl Alcohol EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Lauryl Alcohol do in cosmetics?

Lauryl Alcohol functions as: Emollient, emulsifier, viscosity controlling agent, fragrance ingredient. It is classified as a cosmetic ingredient in our database. CAS number: 112-53-8.

What is the Margin of Safety for Lauryl Alcohol?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Lauryl Alcohol?

The NOAEL (No Observed Adverse Effect Level) for Lauryl Alcohol is 3324 mg/kg bw/day based on a Special Toxicology Study study via oral route in rat. Source: COSMOS_DB.

Is Lauryl Alcohol classified as hazardous under GHS?

Lauryl Alcohol carries a GHS signal word of "WARNING". Hazard statements: Causes skin and eye irritation May cause respiratory irritation May be harmful if swallowed and enters airways Very toxic to aquatic life with long lasting effects. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance โ€” at cosmetic use concentrations, hazard thresholds may not be met.

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