Leptospermone

INCI: LEPTOSPERMONE

CAS Number
567-75-9
Function
Cosmetic agent (β-triketone; natural constituent of Leptospermum essential oils)
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status prohibited
🇺🇸 US Status permitted
US Notes Permitted — no specific CFR restriction; EPA-registered as herbicidal active substance (HPPD inhibitor)

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Potent HPPD inhibitor with demonstrated phytotoxicity at ≥0.8 µM tissue concentration and 50% root-to-shoot translocation within 24 h; typically present as minor component in manuka oil rather than used in isolation; no standalone cosmetic MoS calculation published.

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Concern Level: High

Regulatory Flags

essential-oil

Frequently Asked Questions

Is Leptospermone safe in cosmetics?

Potent HPPD inhibitor with demonstrated phytotoxicity at ≥0.8 µM tissue concentration and 50% root-to-shoot translocation within 24 h; typically present as minor component in manuka oil rather than used in isolation; no standalone cosmetic MoS calculation published. The EU classifies Leptospermone as "prohibited". Safety rating: MODERATE.

Is Leptospermone allowed in the EU?

Leptospermone EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.

What does Leptospermone do in cosmetics?

Leptospermone functions as: Cosmetic agent (β-triketone; natural constituent of Leptospermum essential oils). It is classified as a cosmetic ingredient in our database. CAS number: 567-75-9.

What is the Margin of Safety for Leptospermone?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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