Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
7 study endpoints found for m-Aminophenol. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 20 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| LOAEL | 70 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 0.59 other | dermal | rat | dermal | REACH |
| NOAEL | 70 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 70 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 9.7 other | dermal | code:3543 | dermal | REACH |
| NOAEL | 240 mg/kg bw/day | oral | rat | oral | REACH |
Sensitization Profile
Contact sensitization data for m-Aminophenol based on clinical patch test studies and IFRA standards.
Source: IVDK; NACDG; ESSCA
Expert Verdict
Must not exceed 1.0% in-use concentration after mixing with H₂O₂. Mandatory patch testing labeling in EU. Potential N-nitrosamine formation if combined with nitrosating agents.
Frequently Asked Questions
Is m-Aminophenol safe in cosmetics?
Must not exceed 1.0% in-use concentration after mixing with H₂O₂. Mandatory patch testing labeling in EU. Potential N-nitrosamine formation if combined with nitrosating agents. The EU classifies m-Aminophenol as "restricted". Safety rating: MODERATE. 7 toxicological study endpoint(s) are available in our database.
Is m-Aminophenol allowed in the EU?
m-Aminophenol EU regulatory status: restricted. Maximum allowed concentration: 1.2%. This is based on EU Regulation 1223/2009 and its amendments.
What does m-Aminophenol do in cosmetics?
m-Aminophenol functions as: Oxidative hair dye (coupler). It is classified as a cosmetic ingredient in our database. CAS number: 591-27-5.
What is the Margin of Safety for m-Aminophenol?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for m-Aminophenol?
The NOAEL (No Observed Adverse Effect Level) for m-Aminophenol is 20 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 7 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
Check m-Aminophenol compliance across multiple jurisdictions:
Related Ingredients
Is m-Aminophenol in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for m-Aminophenol in your formulation.