Moderate Cosmetic Ingredient NOAEL Data

Titanium Nitride

INCI: TITANIUM NITRIDE

CAS Number
25583-20-4
Function
Cosmetic colorant
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Not a listed color additive for cosmetics under 21 CFR Parts 73/74; FDA approved only as food-contact surface coating (FCN 1240)

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
negligible
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

4 study endpoints found for Titanium Nitride. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 50000 ppm oral mouse oral REACH
NOAEL 50000 ppm oral rat oral REACH
NOAEL 50000 ppm oral - oral REACH
NOAEL 50000 ppm oral - oral REACH

Expert Verdict

Not FDA-listed as a cosmetic color additive โ€” use in US market requires careful regulatory positioning; nanoparticle concerns may apply if used in nano form

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Concern Level: Moderate

Regulatory Flags

colorant

Frequently Asked Questions

Is Titanium Nitride safe in cosmetics?

Not FDA-listed as a cosmetic color additive โ€” use in US market requires careful regulatory positioning; nanoparticle concerns may apply if used in nano form The EU classifies Titanium Nitride as "permitted". Safety rating: MODERATE. 4 toxicological study endpoint(s) are available in our database.

Is Titanium Nitride allowed in the EU?

Titanium Nitride EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Titanium Nitride do in cosmetics?

Titanium Nitride functions as: Cosmetic colorant. It is classified as a cosmetic ingredient in our database. CAS number: 25583-20-4.

What is the Margin of Safety for Titanium Nitride?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Titanium Nitride?

The NOAEL (No Observed Adverse Effect Level) for Titanium Nitride is 50000 ppm based on a oral study via oral route in mouse. A total of 4 study endpoints are available. Source: REACH.

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