Good Cosmetic Ingredient NOAEL Data GHS Classified

Magnesium Nitrate

INCI: MAGNESIUM NITRATE

CAS Number
10377-60-3
Function
Hair conditioning agent; stabiliser in CMIT/MIT preservative systems
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status permitted
EU Max Conc. 0.0015%
🇺🇸 US Status permitted
US Notes Permitted — listed as indirect food additive (21 CFR §175.300, §175.320, §176.170); no cosmetic-specific CFR restriction

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

2 study endpoints found for Magnesium Nitrate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL >=1500 mg/kg bw/day oral rat oral REACH
NOAEL >=1500 mg/kg bw/day oral - oral REACH

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Short-term Exposure Effects
May cause mechanical irritation to the eyes and respiratory tract. Ingestion could cause effects on the blood. This may result in the formation of methaemoglobin. The effects may be delayed. Medical observation is indicated.
Routes of Exposure
The substance can be absorbed into the body by inhalation of its aerosol and by ingestion.

Expert Verdict

Nitrate source — avoid co-formulation with secondary amines or nitrosating agents due to nitrosamine risk; declare within CMIT/MIT system context.

⚠️
Concern Level: Low

Regulatory Flags

preservative eu_children_restricted epa_safer_alternative ifra_fragrance

Frequently Asked Questions

Is Magnesium Nitrate safe in cosmetics?

Nitrate source — avoid co-formulation with secondary amines or nitrosating agents due to nitrosamine risk; declare within CMIT/MIT system context. The EU classifies Magnesium Nitrate as "permitted". Safety rating: GOOD. 2 toxicological study endpoint(s) are available in our database.

Is Magnesium Nitrate allowed in the EU?

Magnesium Nitrate EU regulatory status: permitted. Maximum allowed concentration: 0.0015%. This is based on EU Regulation 1223/2009 and its amendments.

What does Magnesium Nitrate do in cosmetics?

Magnesium Nitrate functions as: Hair conditioning agent; stabiliser in CMIT/MIT preservative systems. It is classified as a cosmetic ingredient in our database. CAS number: 10377-60-3.

What is the Margin of Safety for Magnesium Nitrate?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Magnesium Nitrate?

The NOAEL (No Observed Adverse Effect Level) for Magnesium Nitrate is >=1500 mg/kg bw/day based on a oral study via oral route in rat. A total of 2 study endpoints are available. Source: REACH.

Compliance Tools

Check Magnesium Nitrate compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
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