Malus Domestica Fruit Cell Culture Extract
INCI: MALUS DOMESTICA FRUIT CELL CULTURE EXTRACT
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
7 study endpoints found for Malus Domestica Fruit Cell Culture Extract. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 30 mg/kg bw/day | dermal | - | - | SCCS_PDF_extraction |
| NOAEL | 30 mg/kg bw/day | - | - | reproductive | SCCS_PDF_extraction |
| NOAEL | 30 mg/kg bw/day | oral | rat | reproductive | SCCS_PDF_extraction |
| NOAEL | 30 mg/kg bw/day | oral | - | reproductive | SCCS_PDF_extraction |
| NOAEL | 30 mg/kg bw/day | dermal | - | - | SCCS_PDF_extraction |
| NOAEL | 30 mg/kg bw/day | oral | - | reproductive | SCCS_PDF_extraction |
| NOAEL | 30 mg/kg bw/day | - | - | reproductive | SCCS_PDF_extraction |
Expert Verdict
Safe botanical antioxidant and anti-wrinkle active via phenolics and flavonoids. Stem cell marketing is inaccurate as these are dead plant extracts, not living cells. Manufacturer clinical data shows 8% wrinkle reduction at 2 weeks and 15% at 4 weeks for crow's feet, but not independently replicated. Use accurate claim language.
Regulatory Flags
Frequently Asked Questions
Is Malus Domestica Fruit Cell Culture Extract safe in cosmetics?
Safe botanical antioxidant and anti-wrinkle active via phenolics and flavonoids. Stem cell marketing is inaccurate as these are dead plant extracts, not living cells. Manufacturer clinical data shows 8% wrinkle reduction at 2 weeks and 15% at 4 weeks for crow's feet, but not independently replicated. Use accurate claim language. The EU classifies Malus Domestica Fruit Cell Culture Extract as "permitted". Safety rating: EXCELLENT. 7 toxicological study endpoint(s) are available in our database.
Is Malus Domestica Fruit Cell Culture Extract allowed in the EU?
Malus Domestica Fruit Cell Culture Extract EU regulatory status: permitted. Maximum allowed concentration: 0.4-2%. This is based on EU Regulation 1223/2009 and its amendments.
What does Malus Domestica Fruit Cell Culture Extract do in cosmetics?
Malus Domestica Fruit Cell Culture Extract functions as: Swiss apple callus extract (Uttwiler Spätlauber); antioxidant; anti-wrinkle; phytochemical delivery via lecithin liposomes; anti-aging. It is classified as a Active Ingredient in our database. CAS number: N/A.
What is the Margin of Safety for Malus Domestica Fruit Cell Culture Extract?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Malus Domestica Fruit Cell Culture Extract?
The NOAEL (No Observed Adverse Effect Level) for Malus Domestica Fruit Cell Culture Extract is 30 mg/kg bw/day based on a toxicological study via dermal route in rat. A total of 7 study endpoints are available. Source: SCCS_PDF_extraction.
Compliance Tools
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