Good Cosmetic Ingredient Sensitization Data

Mentha Piperita Essential Oil

INCI: MENTHA PIPERITA OIL

CAS Number
8006-90-4 / 84082-70-2
Function
Perfuming, skin conditioning, refreshing
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status restricted
🇺🇸 US Status permitted
US Notes Permitted — GRAS under 21 CFR 182.20; CIR: safe when formulated to be non-sensitizing

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Sensitization Profile

Contact sensitization data for Mentha Piperita Essential Oil based on clinical patch test studies and IFRA standards.

Sensitization Rate
low
Allergen Class
fragrance
EU Allergen Listed
no
Patch Test Positive Rate
0.3%
Cross-reactivity Group
none
Reaction Type
contact-dermatitis
IFRA Restricted

Source: IFRA

Expert Verdict

Pulegone (1–4%, hepatotoxic, NTP oral carcinogenicity positive in rats) and menthofuran (1–9%, similar toxicity pathway) present risk; cyst-like brain lesions observed in rats at ≥100 mg/kg/day oral; formulation must ensure non-sensitizing profile with pulegone limit ≤1% recommended by CIR.

⚠️
Concern Level: Moderate

Regulatory Flags

plant-oil potential-allergen fragrance-component

Frequently Asked Questions

Is Mentha Piperita Essential Oil safe in cosmetics?

Pulegone (1–4%, hepatotoxic, NTP oral carcinogenicity positive in rats) and menthofuran (1–9%, similar toxicity pathway) present risk; cyst-like brain lesions observed in rats at ≥100 mg/kg/day oral; formulation must ensure non-sensitizing profile with pulegone limit ≤1% recommended by CIR. The EU classifies Mentha Piperita Essential Oil as "restricted". Safety rating: GOOD.

Is Mentha Piperita Essential Oil allowed in the EU?

Mentha Piperita Essential Oil EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.

What does Mentha Piperita Essential Oil do in cosmetics?

Mentha Piperita Essential Oil functions as: Perfuming, skin conditioning, refreshing. It is classified as a cosmetic ingredient in our database. CAS number: 8006-90-4 / 84082-70-2.

What is the Margin of Safety for Mentha Piperita Essential Oil?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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