Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Meroxapol 312. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 25000 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 30000 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 480 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 3000 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 1000 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 200 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 500 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 1000 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 1000 mg/kg bw/day | oral | dog | Subchronic | COSMOS_DB |
| NOAEL | 40 mg/kg bw/day | oral | dog | Subchronic | COSMOS_DB |
Expert Verdict
Low concern; as with all meroxapol grades, irritation potential is concentration-dependent; no specific CIR or SCCS opinion on this grade. Higher PEO content relative to Meroxapol 311 (indicated by the "2" in the last digit position), conferring slightly more hydrophilic character and emulsification capacity
Regulatory Flags
Frequently Asked Questions
Is Meroxapol 312 safe in cosmetics?
Low concern; as with all meroxapol grades, irritation potential is concentration-dependent; no specific CIR or SCCS opinion on this grade. Higher PEO content relative to Meroxapol 311 (indicated by the "2" in the last digit position), conferring slightly more hydrophilic character and emulsification capacity The EU classifies Meroxapol 312 as "permitted". Safety rating: MODERATE. 10 toxicological study endpoint(s) are available in our database.
Is Meroxapol 312 allowed in the EU?
Meroxapol 312 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Meroxapol 312 do in cosmetics?
Meroxapol 312 functions as: Surfactant - Cleansing; Surfactant - Emulsifying. It is classified as a cosmetic ingredient in our database. CAS number: 9003-11-6.
What is the Margin of Safety for Meroxapol 312?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Meroxapol 312?
The NOAEL (No Observed Adverse Effect Level) for Meroxapol 312 is 25000 mg/kg bw/day based on a Short Term Toxicity study via oral route in rat. A total of 10 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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