Methacryloyloxyethyl Phosphorylcholine

INCI: LISTED UNDER POLYMER FORMS (E.G., AS A COMPONENT OF POLYQUATERNIUM-61 AND RELATED PHOSPHORYLCHOLINE COPOLYMERS)

CAS Number
67881-98-5
Function
Film forming, hair conditioning, skin conditioning, humectant (as polymeric derivatives)
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Allowed - CIR Expert Panel concluded that acryloyloxyethyl phosphorylcholine polymers are safe in cosmetics at present practices of use and concentration

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

The monomer itself is a zwitterionic compound with low toxicity; polymerized forms show excellent biocompatibility; reduced skin penetration of co-formulated parabens demonstrated in studies. Mimics the phospholipid head group of cell membranes (phosphatidylcholine); polymers formed from MPC are exceptionally biocompatible, anti-fouling, and moisture-retaining - widely used in biomedical devices as well as cosmetics

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Concern Level: High

Frequently Asked Questions

Is Methacryloyloxyethyl Phosphorylcholine safe in cosmetics?

The monomer itself is a zwitterionic compound with low toxicity; polymerized forms show excellent biocompatibility; reduced skin penetration of co-formulated parabens demonstrated in studies. Mimics the phospholipid head group of cell membranes (phosphatidylcholine); polymers formed from MPC are exceptionally biocompatible, anti-fouling, and moisture-retaining - widely used in biomedical devices as well as cosmetics The EU classifies Methacryloyloxyethyl Phosphorylcholine as "permitted". Safety rating: MODERATE.

Is Methacryloyloxyethyl Phosphorylcholine allowed in the EU?

Methacryloyloxyethyl Phosphorylcholine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Methacryloyloxyethyl Phosphorylcholine do in cosmetics?

Methacryloyloxyethyl Phosphorylcholine functions as: Film forming, hair conditioning, skin conditioning, humectant (as polymeric derivatives). It is classified as a cosmetic ingredient in our database. CAS number: 67881-98-5.

What is the Margin of Safety for Methacryloyloxyethyl Phosphorylcholine?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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