Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Expert Verdict
The parent compound melittin is the primary active component of bee venom and is a known cytolytic peptide at high concentrations; the cosmetic-grade synthetic version is used at very low, controlled concentrations; potential allergenicity in individuals with bee venom allergy. Single-chain peptide of 70 amino acids, produced synthetically to be identical to bee venom melittin; may contain disulfide bonds and/or glycosylation; leverages melittin's biological activity for skin-tightening/prote...
Regulatory Flags
Frequently Asked Questions
Is Methionyl s-Melittin SP safe in cosmetics?
The parent compound melittin is the primary active component of bee venom and is a known cytolytic peptide at high concentrations; the cosmetic-grade synthetic version is used at very low, controlled concentrations; potential allergenicity in individuals with bee venom allergy. Single-chain peptide of 70 amino acids, produced synthetically to be identical to bee venom melittin; may contain disulfide bonds and/or glycosylation; leverages melittin's biological activity for skin-tightening/prote... The EU classifies Methionyl s-Melittin SP as "permitted". Safety rating: MODERATE.
Is Methionyl s-Melittin SP allowed in the EU?
Methionyl s-Melittin SP EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Methionyl s-Melittin SP do in cosmetics?
Methionyl s-Melittin SP functions as: Skin Protecting. It is classified as a cosmetic ingredient in our database. CAS number: Not assigned for the cosmetic-grade methionyl variant (native melittin CAS: 20449-79-0).
What is the Margin of Safety for Methionyl s-Melittin SP?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
Compliance Tools
Check Methionyl s-Melittin SP compliance across multiple jurisdictions:
Related Ingredients
Is Methionyl s-Melittin SP in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Methionyl s-Melittin SP in your formulation.