Moderate Cosmetic Ingredient NOAEL Data

Methoxyethyl Acrylate

INCI: METHOXYETHYL ACRYLATE

CAS Number
3121-61-7
Function
Film forming (monomer/polymer precursor)
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Allowed - no specific prohibition; acrylate monomers are common in nail and adhesive products

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

1 study endpoint found for Methoxyethyl Acrylate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
LOAEL 40 mg/kg bw/day oral rat oral REACH

Expert Verdict

Acrylate monomers are potent contact allergens and skin/respiratory sensitizers; occupational exposure linked to allergic contact dermatitis, particularly in nail technicians. 2-Methoxyethyl 2-propenoate; produces flexible copolymers with good adhesion; used as a softening comonomer in acrylic polymer systems

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Concern Level: Moderate

Regulatory Flags

potential-allergen

Frequently Asked Questions

Is Methoxyethyl Acrylate safe in cosmetics?

Acrylate monomers are potent contact allergens and skin/respiratory sensitizers; occupational exposure linked to allergic contact dermatitis, particularly in nail technicians. 2-Methoxyethyl 2-propenoate; produces flexible copolymers with good adhesion; used as a softening comonomer in acrylic polymer systems The EU classifies Methoxyethyl Acrylate as "permitted". Safety rating: MODERATE. 1 toxicological study endpoint(s) are available in our database.

Is Methoxyethyl Acrylate allowed in the EU?

Methoxyethyl Acrylate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Methoxyethyl Acrylate do in cosmetics?

Methoxyethyl Acrylate functions as: Film forming (monomer/polymer precursor). It is classified as a cosmetic ingredient in our database. CAS number: 3121-61-7.

What is the Margin of Safety for Methoxyethyl Acrylate?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Methoxyethyl Acrylate?

The NOAEL (No Observed Adverse Effect Level) for Methoxyethyl Acrylate is 40 mg/kg bw/day based on a oral study via oral route in rat. Source: REACH.

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