NOAEL Studies
Fragrance
Methyl Eugenol NOAEL Studies
INCI: METHYL EUGENOL
CAS: 93-15-2
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
COSMOS_DB 7 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| COSMOS_DB | LOAEL | 10 | mg/kg bw/day | rat | oral | 14 week | Subchronic | PAFA; NTP TR 491 |
| COSMOS_DB | LOAEL | 30 | mg/kg bw/day | mouse | oral | 14 week | Subchronic | PAFA; NTP TR 491 |
| COSMOS_DB | NOAEL | 18 | mg/kg bw/day | rat | oral | 91 day | Subchronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 300 | mg/kg bw/day | mouse | oral | 98 day | Subchronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 30 | mg/kg bw/day | rat | oral | 98 day | Subchronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 37 | mg/kg bw/day | rat | oral | 735 day | Carcinogenicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 10 | mg/kg bw/day | mouse | oral | 14 week | Subchronic | PAFA; NTP TR 491 |
California Proposition 65 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| California Proposition 65 | California Proposition 65 listing | ABcancer | listing type | - | - | 2001-11-16 | California Proposition 65 listing | {"cancer_reproductive":"cancer","listed_date":"2001-11-16","listing_mechanism":"AB","madl":null,"nsrl":null,"source_table":"prop65_listings"} |
| California Proposition 65 | California Proposition 65 listing | ABcancer | listing type | - | - | 2001-11-16 | California Proposition 65 listing | {"cancer_reproductive":"cancer","listed_date":"2001-11-16","listing_mechanism":"AB","madl":null,"nsrl":null,"source_table":"prop65_listings"} |
| California Proposition 65 | California Proposition 65 listing | ABcancer | listing type | - | - | 2001-11-16 | California Proposition 65 listing | {"cancer_reproductive":"cancer","listed_date":"2001-11-16","listing_mechanism":"AB","madl":null,"nsrl":null,"source_table":"prop65_listings"} |
| California Proposition 65 | California Proposition 65 listing | ABcancer | listing type | - | - | 2001-11-16 | California Proposition 65 listing | {"cancer_reproductive":"cancer","listed_date":"2001-11-16","listing_mechanism":"AB","madl":null,"nsrl":null,"source_table":"prop65_listings"} |
IARC Monographs 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| IARC Monographs | IARC carcinogenicity classification | 2A | IARC group | - | - | 2023 | IARC Monographs | {"additional_info":"volume_publication_year=2024","evaluation_year":2023,"source_table":"iarc_classifications","volume":"101, 134"} |
NTP_ICE_acute_dermal 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_acute_dermal | EPA classification | 4 | unitless | Rat | Dermal | - | In Vivo; Rat Acute Dermal Toxicity | sheet=Data; excel_row=1321; Record_ID=acute_dermal_466; Data_Type=In Vivo; Formulation_ID=MIX460; Formulation_Name=Splat-Mat ME; Percent_Active_Ingredient=51.0; Mixture=Mixture; DTXSID=DTXSID5025607; Assay=Rat Acute Dermal Toxicity; Endpoint=EPA classification; Response=4.0; Response_Unit=Unitless; Species=Rat; Route=Dermal; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025607; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025607 |
| NTP_ICE_acute_dermal | GHS classification | 5 | unitless | Rat | Dermal | - | In Vivo; Rat Acute Dermal Toxicity | sheet=Data; excel_row=1322; Record_ID=acute_dermal_466; Data_Type=In Vivo; Formulation_ID=MIX460; Formulation_Name=Splat-Mat ME; Percent_Active_Ingredient=51.0; Mixture=Mixture; DTXSID=DTXSID5025607; Assay=Rat Acute Dermal Toxicity; Endpoint=GHS classification; Response=5.0; Response_Unit=Unitless; Species=Rat; Route=Dermal; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025607; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025607 |
| NTP_ICE_acute_dermal | LD50 | >5000 | mg/kg | Rat | Dermal | - | In Vivo; Rat Acute Dermal Toxicity | sheet=Data; excel_row=1320; Record_ID=acute_dermal_466; Data_Type=In Vivo; Formulation_ID=MIX460; Formulation_Name=Splat-Mat ME; Percent_Active_Ingredient=51.0; Mixture=Mixture; DTXSID=DTXSID5025607; Assay=Rat Acute Dermal Toxicity; Endpoint=LD50; Response_Modifier=>; Response=5000.0; Response_Unit=mg/kg; Species=Rat; Route=Dermal; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025607; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025607 |
NTP_ICE_acute_inhalation 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_acute_inhalation | LC50 | >4.8 | mg/L | - | Inhalation | - | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=2908; Record_ID=acute_inhalation_3050; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID5025607; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=4.8; Response_Unit=mg/L; Reference=ChemIDplus; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025607; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025607 |
NTP_ICE_acute_oral 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_acute_oral | EPA classification | =4 | Unitless | Rat (Female) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_13014; row=8904; data_type=In Vivo; mixture=Mixture; formulation_id=MIX460; formulation_name=Splat-Mat ME; chemical_name=Methyleugenol; preferred_name=1,2-Dimethoxy-4-(2-propen-1-yl)benzene; percent_active_ingredient=51.0; dtxsid=DTXSID5025607; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025607; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5025607; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | GHS classification | =5 | Unitless | Rat (Female) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_13014; row=8905; data_type=In Vivo; mixture=Mixture; formulation_id=MIX460; formulation_name=Splat-Mat ME; chemical_name=Methyleugenol; preferred_name=1,2-Dimethoxy-4-(2-propen-1-yl)benzene; percent_active_ingredient=51.0; dtxsid=DTXSID5025607; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025607; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5025607; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | >5000 | mg/kg bw | Rat (Female) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_13014; row=8906; data_type=In Vivo; mixture=Mixture; formulation_id=MIX460; formulation_name=Splat-Mat ME; chemical_name=Methyleugenol; preferred_name=1,2-Dimethoxy-4-(2-propen-1-yl)benzene; percent_active_ingredient=51.0; dtxsid=DTXSID5025607; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025607; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5025607; source_file=acute_oral.xlsx |
NTP_ICE_adme_parameters 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_adme_parameters | Clint | 26.56 | uL/min/10^6 cells | Human | - | - | Measured; httk, Human Hepatic Intrinsic Clearance | sheet=Data; excel_row=2087; Record_ID=adme_parameters_377; Data_Type=Measured; DTXSID=DTXSID5025607; Assay=httk, Human Hepatic Intrinsic Clearance; Endpoint=Clint; Response=26.56; Response_Unit=ul/min/10^6 cells; Species=Human; Reference=httk2.3.1, Wetmore 2015; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025607; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025607 |
| NTP_ICE_adme_parameters | Fu | 0.1416 | fraction | Human | - | - | Measured; httk, Human Plasma Fraction Unbound | sheet=Data; excel_row=2088; Record_ID=adme_parameters_377; Data_Type=Measured; DTXSID=DTXSID5025607; Assay=httk, Human Plasma Fraction Unbound; Endpoint=Fu; Response=0.1416; Response_Unit=Unitless Fraction; Species=Human; Reference=httk2.3.1, Wetmore 2015; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025607; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025607 |
NTP_ICE_cancer 7 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_cancer | IARC group | 2 | unitless | - | - | - | WOE; IARC Carcinogenicity | sheet=Data; excel_row=6052; Record_ID=cancer_4974; Data_Type=WOE; Formulation_Name=Methyleugenol; Mixture=Chemical; DTXSID=DTXSID5025607; Assay=IARC Carcinogenicity; Endpoint=IARC group; Response=2B; Response_Unit=Unitless; URL=http://publications.iarc.fr/125; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025607; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025607 |
| NTP_ICE_cancer | POLY-3 lowest dose | 37 | mg/kg bw/day | Mouse | Gavage | - | In Vivo; Two year cancer bioassay | sheet=Data; excel_row=6051; Record_ID=cancer_4973; Data_Type=In Vivo; Formulation_Name=Methyleugenol; Mixture=Chemical; DTXSID=DTXSID5025607; Assay=Two year cancer bioassay; Endpoint=POLY-3 lowest dose; Response=37; Response_Unit=mg/kg/day; Species=Mouse; Strain=B6C3F1; Sex=Female; Route=Gavage; Level_of_Evidence=Clear evidence; Tissue=Liver; Lesion=Hepatocellular carcinoma, hepatocellular adenoma, or hepatoblastoma; Reference=TR-491; URL=https://ntp.niehs.nih.gov/publications/reports/tr/400s/tr491/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025607; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025607 |
| NTP_ICE_cancer | POLY-3 lowest dose | 300 | mg/kg bw/day | Rat | Gavage | - | In Vivo; Two year cancer bioassay | sheet=Data; excel_row=6059; Record_ID=cancer_4978; Data_Type=In Vivo; Formulation_Name=Methyleugenol; Mixture=Chemical; DTXSID=DTXSID5025607; Assay=Two year cancer bioassay; Endpoint=POLY-3 lowest dose; Response=300; Response_Unit=mg/kg/day; Species=Rat; Strain=F344/N; Sex=Male; Route=Gavage; Level_of_Evidence=Clear evidence; Tissue=Kidney; Location=Renal tubule; Lesion=Adenoma; Reference=TR-491; URL=https://ntp.niehs.nih.gov/publications/reports/tr/400s/tr491/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025607; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025607 |
| NTP_ICE_cancer | POLY-3 lowest dose | 150 | mg/kg bw/day | Rat | Gavage | - | In Vivo; Two year cancer bioassay | sheet=Data; excel_row=6061; Record_ID=cancer_4978; Data_Type=In Vivo; Formulation_Name=Methyleugenol; Mixture=Chemical; DTXSID=DTXSID5025607; Assay=Two year cancer bioassay; Endpoint=POLY-3 lowest dose; Response=150; Response_Unit=mg/kg/day; Species=Rat; Strain=F344/N; Sex=Male; Route=Gavage; Level_of_Evidence=Clear evidence; Tissue=Glandular stomach; Lesion=Neuroendocrine cell tumor(Malignant); Reference=TR-491; URL=https://ntp.niehs.nih.gov/publications/reports/tr/400s/tr491/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025607; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025607 |
| NTP_ICE_cancer | POLY-3 lowest dose | 75 | mg/kg bw/day | Rat | Gavage | - | In Vivo; Two year cancer bioassay | sheet=Data; excel_row=6062; Record_ID=cancer_4978; Data_Type=In Vivo; Formulation_Name=Methyleugenol; Mixture=Chemical; DTXSID=DTXSID5025607; Assay=Two year cancer bioassay; Endpoint=POLY-3 lowest dose; Response=75; Response_Unit=mg/kg/day; Species=Rat; Strain=F344/N; Sex=Male; Route=Gavage; Level_of_Evidence=Clear evidence; Tissue=Mammary gland; Lesion=Fibroadenoma; Reference=TR-491; URL=https://ntp.niehs.nih.gov/publications/reports/tr/400s/tr491/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025607; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025607 |
| NTP_ICE_cancer | Top dose | 300 | mg/kg | Rat | Gavage | - | In Vivo; NTP Carcinogenicity | sheet=Data; excel_row=6056; Record_ID=cancer_4977; Data_Type=In Vivo; Formulation_Name=Methyleugenol; Mixture=Chemical; DTXSID=DTXSID5025607; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=300; Response_Unit=mg/kg; Species=Rat; Strain=F344/N; Sex=Female; Route=Gavage; Reference=TR-491; URL=https://ntp.niehs.nih.gov/publications/reports/tr/400s/tr491/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025607; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025607 |
| NTP_ICE_cancer | Top dose | 150 | mg/kg | Mouse | Gavage | - | In Vivo; NTP Carcinogenicity | sheet=Data; excel_row=6067; Record_ID=cancer_4970; Data_Type=In Vivo; Formulation_Name=Methyleugenol; Mixture=Chemical; DTXSID=DTXSID5025607; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=150; Response_Unit=mg/kg; Species=Mouse; Strain=B6C3F1; Sex=Male; Route=Gavage; Reference=TR-491; URL=https://ntp.niehs.nih.gov/publications/reports/tr/400s/tr491/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025607; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025607 |
NTP_ICE_endocrine 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=494; RecordID=ARPathway2016_1726; DatasetName=ARPathway2016; DTXSID=DTXSID5025607; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025607; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025607 |
NTP_ICE_eye_irritation 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_eye_irritation | EPA Classification | 4 | unitless | Rabbit | Ocular | - | In Vivo; Draize Eye Irritation/Corrosion Test | sheet=Data; excel_row=1573; Record_ID=eye_irritation_1062; Data_Type=In Vivo; Formulation_ID=EyeIrritation6pack_PID900; Formulation_Name=Splat-Mat ME; Percent_Active_Ingredient=51.0; Mixture=Mixture; DTXSID=DTXSID5025607; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=EPA Classification; Response=4; Response_Unit=Unitless; Species=Rabbit; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025607; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025607 |
NTP_ICE_skin_irritation 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_skin_irritation | EPA classification | 4 | unitless | Rabbit | Dermal | - | In Vivo; Draize Skin Irritation/Corrosion Test | sheet=Data_invivo; excel_row=1045; Record_ID=skin_irritation_invivo_809; Data_Type=In Vivo; Formulation_ID=MIX460; Formulation_Name=Splat-Mat ME; Percent_Active_Ingredient=51; Mixture=Mixture; DTXSID=DTXSID5025607; Assay=Draize Skin Irritation/Corrosion Test; Endpoint=EPA classification; Response=4; Response_Unit=Unitless; Species=Rabbit; Reported_Strain=New Zealand White; Strain=New Zealand White; Sex=Female; Reference=FIFRA (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025607; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025607 |
NTP_ICE_skin_sensitization 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_skin_sensitization | Incidence of positive responses | 0 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=11092; Record_ID=skin_sensitization_invivo_2426; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=8.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5025607; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1972: report to RIFM|Opdyke 1975; Not available; 10.1016/0015-6264(75)90251-5; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025607; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025607 |
| NTP_ICE_skin_sensitization | Induction dose per skin area | 5184 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=11090; Record_ID=skin_sensitization_invivo_2426; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=8.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5025607; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=5184; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1972: report to RIFM|Opdyke 1975; Not available; 10.1016/0015-6264(75)90251-5; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025607; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025607 |
| NTP_ICE_skin_sensitization | Relative reliability score | 3 | unitless | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=11096; Record_ID=skin_sensitization_invivo_2426; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=8.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5025607; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Kligman 1972: report to RIFM|Opdyke 1975; Not available; 10.1016/0015-6264(75)90251-5; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025607; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025607 |
ToxRefDB_ToxRefDB_v3_pod.csv 8 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =10 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 week to 14 week | SUB | study_id=5481; toxval_study_source_id=studyid5481_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight|in life observation-body weight-body weight gain|pathology microscopic-salivary glands-cytoplasmic alteration|in life observation-clinical signs-urine staining - perineum|in life observation-clinical signs-emaciation|hematology-platelet-platelet|pathology microscopic-stomach-inflammation|organ weight-liver-relative to body weight|clinical chemistry-protein-protein|clinical chemistry-albumin-albumin|organ weight-liver-absolute|clinical chemistry-bile acids-bile acids|clinical chemistry-creatinine-creatinine|hematology-hemoglobin (hgb)-hemoglobin (hgb)|pathology microscopic-liver-cytomegaly|pathology microscopic-uterus-atrophy|hematology-mean corpuscular hemoglobin (mch)-mean corpuscular hemoglobin (mch)|pathology microscopic-stomach-atrophy|hematology-hematocrit (hct)-hematocrit (hct)|clinical chemistry-alanine aminotransferase (alt/sgpt)-alanine aminotransferase (alt/sgpt)|pathology gross-uterus-reduced size|clinical chemistry-sorbitol dehydrogenase-sorbitol dehydrogenase|pathology gross-uterus-thinning|hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|pathology microscopic-adrenal gland-hypertrophy|pathology microscopic-liver-mixed cell focus|pathology gross-liver-foci|organ weight-thymus-absolute|pathology microscopic-liver-hyperplasia|pathology microscopic-liver-cytologic alterations|organ weight-thymus-relative to body weight|pathology microscopic-liver-pigmentation; dose_level=1; study_year=2000; study_citation=NTP_2000_Toxicology and Carcinogenesis Studies of Methyleugenol (CAS NO. 93-15-2) in F344/N Rats and B6C3F1 Mice (Gavage Studies)_Subchronic_Rats; dsstox_substance_id=DTXSID5025607; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =30 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 week to 14 week | SUB | study_id=5482; toxval_study_source_id=studyid5482_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-stomach-degeneration|pathology microscopic-stomach-mitotic alteration|pathology microscopic-stomach-cyst|in life observation-body weight-body weight gain|pathology microscopic-stomach-atrophy|pathology microscopic-liver-hyperplasia|pathology microscopic-liver-necrosis|pathology microscopic-stomach-edema|organ weight-liver-relative to body weight|pathology microscopic-liver-cytologic alterations|in life observation-mortality-mortality|pathology microscopic-liver-inflammation|organ weight-liver-absolute|pathology microscopic-stomach-necrosis|pathology gross-liver-discolored|pathology gross-liver-enlarged; dose_level=2; study_year=2000; study_citation=NTP_2000_Toxicology and Carcinogenesis Studies of Methyleugenol (CAS NO. 93-15-2) in F344/N Rats and B6C3F1 Mice (Gavage Studies)_Subchronic_Mice; dsstox_substance_id=DTXSID5025607; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =37 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 week to 105 week | CHR | study_id=5484; toxval_study_source_id=studyid5484_Adult_F0_F_systemic; toxval_effect_list=pathology gross-liver-discolored|pathology microscopic-liver-eosinophilic focus|pathology microscopic-spleen-fibrosis|pathology microscopic-liver-hyperplasia|pathology gross-stomach-mass|pathology microscopic-liver-degeneration|pathology gross-liver-nodule(s)|pathology microscopic-bone marrow-hyperplasia|pathology microscopic-liver-hepatocellular adenoma|pathology microscopic-stomach-neoplasm nos|pathology microscopic-stomach-hyperplasia|pathology gross-liver-mass|pathology microscopic-stomach-atrophy|pathology microscopic-salivary glands-cytoplasmic alteration|pathology microscopic-liver-hypertrophy|pathology microscopic-liver-hepatocholangiocarcinoma|pathology microscopic-liver-mixed cell focus|pathology gross-stomach-thickened|in life observation-body weight-body weight|pathology microscopic-liver-hepatocellular carcinoma|pathology microscopic-liver-hepatocholangioma|pathology microscopic-kidney-nephropathy|pathology microscopic-stomach-squamous cell papilloma|in life observation-mortality-mortality; dose_level=1; study_year=2000; study_citation=NTP_2000_Toxicology and Carcinogenesis Studies of Methyleugenol (CAS NO. 93-15-2) in F344/N Rats and B6C3F1 Mice (Gavage Studies)_Chronic_Rats; dsstox_substance_id=DTXSID5025607; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LOAEL | =300 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 week to 14 week | SUB | study_id=5481; toxval_study_source_id=studyid5481_Adult_F0_F_systemic; toxval_effect_list=organ weight-liver-relative to body weight|organ weight-liver-absolute|clinical chemistry-bile acids-bile acids|pathology microscopic-stomach-inflammation|pathology microscopic-liver-cytomegaly|in life observation-body weight-body weight|in life observation-body weight-body weight gain|pathology microscopic-stomach-atrophy; dose_level=4; study_year=2000; study_citation=NTP_2000_Toxicology and Carcinogenesis Studies of Methyleugenol (CAS NO. 93-15-2) in F344/N Rats and B6C3F1 Mice (Gavage Studies)_Subchronic_Rats; dsstox_substance_id=DTXSID5025607; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LOAEL | =75 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 week to 105 week | CHR | study_id=5484; toxval_study_source_id=studyid5484_Adult_F0_F_systemic; toxval_effect_list=pathology gross-liver-discolored|pathology gross-stomach-mass|pathology microscopic-liver-eosinophilic focus|pathology microscopic-liver-hyperplasia|pathology gross-liver-nodule(s)|pathology microscopic-stomach-hyperplasia|pathology gross-liver-mass|pathology microscopic-liver-hypertrophy|in life observation-body weight-body weight|pathology gross-stomach-thickened|pathology microscopic-stomach-atrophy; dose_level=2; study_year=2000; study_citation=NTP_2000_Toxicology and Carcinogenesis Studies of Methyleugenol (CAS NO. 93-15-2) in F344/N Rats and B6C3F1 Mice (Gavage Studies)_Chronic_Rats; dsstox_substance_id=DTXSID5025607; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NEL | >0 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 week to 14 week | SUB | study_id=5481; toxval_study_source_id=studyid5481_Adult_F0_F_systemic; toxval_effect_list=clinical chemistry-bile acids-bile acids|organ weight-thymus-relative to body weight|pathology microscopic-stomach-inflammation|clinical chemistry-creatinine-creatinine|organ weight-liver-relative to body weight|pathology microscopic-liver-pigmentation|clinical chemistry-protein-protein|clinical chemistry-albumin-albumin|organ weight-liver-absolute|pathology microscopic-salivary glands-cytoplasmic alteration|pathology microscopic-liver-cytomegaly|pathology microscopic-liver-mixed cell focus|pathology gross-liver-foci|pathology microscopic-uterus-atrophy|in life observation-body weight-body weight|organ weight-thymus-absolute|hematology-hemoglobin (hgb)-hemoglobin (hgb)|pathology microscopic-liver-hyperplasia|in life observation-clinical signs-emaciation|hematology-platelet-platelet|pathology microscopic-liver-cytologic alterations|hematology-mean corpuscular hemoglobin (mch)-mean corpuscular hemoglobin (mch)|in life observation-clinical signs-urine staining - perineum|hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|pathology microscopic-adrenal gland-hypertrophy|clinical chemistry-alanine aminotransferase (alt/sgpt)-alanine aminotransferase (alt/sgpt)|in life observation-body weight-body weight gain|pathology microscopic-stomach-atrophy|hematology-hematocrit (hct)-hematocrit (hct)|pathology gross-uterus-reduced size|clinical chemistry-sorbitol dehydrogenase-sorbitol dehydrogenase|pathology gross-uterus-thinning; dose_level=0; study_year=2000; study_citation=NTP_2000_Toxicology and Carcinogenesis Studies of Methyleugenol (CAS NO. 93-15-2) in F344/N Rats and B6C3F1 Mice (Gavage Studies)_Subchronic_Rats; dsstox_substance_id=DTXSID5025607; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NEL | =10 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 week to 14 week | SUB | study_id=5482; toxval_study_source_id=studyid5482_Adult_F0_F_systemic; toxval_effect_list=organ weight-liver-absolute|pathology gross-liver-discolored|pathology microscopic-stomach-degeneration|pathology gross-liver-enlarged|pathology microscopic-stomach-cyst|pathology microscopic-liver-inflammation|pathology microscopic-stomach-mitotic alteration|in life observation-mortality-mortality|pathology microscopic-stomach-necrosis|pathology microscopic-liver-cytologic alterations|organ weight-liver-relative to body weight|pathology microscopic-stomach-edema|pathology microscopic-liver-necrosis|pathology microscopic-stomach-atrophy|pathology microscopic-liver-hyperplasia|in life observation-body weight-body weight gain; dose_level=1; study_year=2000; study_citation=NTP_2000_Toxicology and Carcinogenesis Studies of Methyleugenol (CAS NO. 93-15-2) in F344/N Rats and B6C3F1 Mice (Gavage Studies)_Subchronic_Mice; dsstox_substance_id=DTXSID5025607; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NOAEL | =100 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 week to 14 week | SUB | study_id=5481; toxval_study_source_id=studyid5481_Adult_F0_F_systemic; toxval_effect_list=clinical chemistry-alanine aminotransferase (alt/sgpt)-alanine aminotransferase (alt/sgpt)|in life observation-body weight-body weight gain|pathology microscopic-stomach-atrophy|hematology-hematocrit (hct)-hematocrit (hct)|pathology gross-uterus-reduced size|clinical chemistry-sorbitol dehydrogenase-sorbitol dehydrogenase|pathology gross-uterus-thinning|hematology-mean corpuscular hemoglobin (mch)-mean corpuscular hemoglobin (mch)|in life observation-clinical signs-urine staining - perineum|hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|pathology microscopic-adrenal gland-hypertrophy|pathology microscopic-salivary glands-cytoplasmic alteration|pathology microscopic-liver-cytomegaly|pathology microscopic-liver-mixed cell focus|pathology gross-liver-foci|in life observation-body weight-body weight|pathology microscopic-uterus-atrophy|organ weight-thymus-absolute|hematology-hemoglobin (hgb)-hemoglobin (hgb)|pathology microscopic-liver-hyperplasia|in life observation-clinical signs-emaciation|hematology-platelet-platelet|pathology microscopic-liver-cytologic alterations|clinical chemistry-bile acids-bile acids|organ weight-thymus-relative to body weight|pathology microscopic-stomach-inflammation|clinical chemistry-creatinine-creatinine|organ weight-liver-relative to body weight|clinical chemistry-protein-protein|pathology microscopic-liver-pigmentation|clinical chemistry-albumin-albumin|organ weight-liver-absolute; dose_level=3; study_year=2000; study_citation=NTP_2000_Toxicology and Carcinogenesis Studies of Methyleugenol (CAS NO. 93-15-2) in F344/N Rats and B6C3F1 Mice (Gavage Studies)_Subchronic_Rats; dsstox_substance_id=DTXSID5025607; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
ToxValDB_ECHA_IUCLID 5 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECHA_IUCLID | LOAEL | =80 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac93e4b0a7c65d1bfc8f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16390/7/9/3?documentUUID=228b6140-213d-49bd-9511-ef9845c56ff3; YEAR=2019; ORIGINAL_YEAR=2019; TOXICOLOGICAL_EFFECT=maternal: clinical signs|maternal: organ weights and organ / body weight ratios; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs|organ weight; STUDY_GROUP=ECHA IUCLID:15825301:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_f888e8c13c7e08a6860485b45d8692ea |
| ToxValDB_ECHA_IUCLID | LOEL | =37 | mg/kg bw/day | Rat | oral | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa2fe4b0a7c65d1b4b4a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16390/7/8?documentUUID=228b6140-213d-49bd-9511-ef9845c56ff3; YEAR=2019; ORIGINAL_YEAR=2019; TOXICOLOGICAL_EFFECT=body weight and weight gain|gross pathology|histopathology: neoplastic|histopathology: non-neoplastic; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|cancer|gross pathology|nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID:15820260:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_9d6d237c114e474518bcca230a3d9563 |
| ToxValDB_ECHA_IUCLID | NOAEL | >300 | mg/kg bw/day | Rat | oral | subchronic (developmental); 48 days | reproduction developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf70e4b0a7c65d1cdf2a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16390/7/6/2?documentUUID=337b8d8b-d2e6-4d61-b58c-f48977b7f7e4; YEAR=2018; ORIGINAL_YEAR=2018; STUDY_GROUP=ECHA IUCLID:15848508:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_3e2eb7aa2166db292f43d81f507b91f7 |
| ToxValDB_ECHA_IUCLID | NOAEL | =1000 | mg/kg bw/day | Rat | oral | - | developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab94e4b0a7c65d1bacac; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16390/7/9/2?documentUUID=337b8d8b-d2e6-4d61-b58c-f48977b7f7e4; YEAR=2018; ORIGINAL_YEAR=2018; STUDY_GROUP=ECHA IUCLID:15861054:M/F:F1-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_40d6d6d62865a263beb5f4f349baba89 |
| ToxValDB_ECHA_IUCLID | NOEL | =10 | mg/kg bw/day | Mouse | oral | chronic; 14 weeks | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf70e4b0a7c65d1cdf33; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16390/7/6/2?documentUUID=228b6140-213d-49bd-9511-ef9845c56ff3; YEAR=2019; ORIGINAL_YEAR=2019; TOXICOLOGICAL_EFFECT=histopathology: nonneoplastic; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID:15850002:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_8ff2e65861bc60c8098567ba246cf794 |
ToxValDB_ECOTOX 6 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECOTOX | LOEL | =100 | mg/kg bw/day | Rat | injection | subchronic; 53 days | subchronic | LONG_REF=Pharmacology14(4): 367-377 Sell,A.B., and E.A. Carlini Anesthetic Action of Methyleugenol and Other Eugenol Derivatives 1976; TITLE=Anesthetic Action of Methyleugenol and Other Eugenol Derivatives; AUTHOR=Sell,A.B., and E.A. Carlini; DOI=10.1159/000136617; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=81555; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1976; ORIGINAL_YEAR=1976; TOXICOLOGICAL_EFFECT=Growth: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECOTOX:15605401:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=bb83f98b6f8687d448d219238b50a4e7 |
| ToxValDB_ECOTOX | LOEL | =300 | mg/kg bw/day | Rat | oral | chronic; 52 weeks | chronic | LONG_REF=- | J. Agric. Food Chem.48(8): 3620-3632 Johnson,J.D., M.J. Ryan, J.D. Toft II, S.W. Graves, M.R. Hejtmancik, M.L. Cunningham, R. Herbert, and K.M. Abdo Two-Year Toxicity and Carcinogenicity Study of Methyleugenol in F344/N Rats and B6C3F1 Mice 2000; TITLE=Two-Year Toxicity and Carcinogenicity Study of Methyleugenol in F344/N Rats and B6C3F1 Mice; AUTHOR=Johnson,J.D., M.J. Ryan, J.D. Toft II, S.W. Graves, M.R. Hejtmancik, M.L. Cunningham, R. Herbert, and K.M. Abdo; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=81451; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2000; ORIGINAL_YEAR=2000; TOXICOLOGICAL_EFFECT=Histology: Neoplastic and nonneoplastic lesion in liver, Nonneoplastic lesion in glandular stomach: atrophy; TOXICOLOGICAL_EFFECT_CATEGORY=cancer; STUDY_GROUP=ECOTOX:15612964:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=b1c233239bd0d7e265bce00b68f67776 |
| ToxValDB_ECOTOX | LOEL | =37 | mg/kg bw/day | Rat | oral | short-term; 30 days | short-term | LONG_REF=- | Food Chem. Toxicol.39(4): 303-316 Abdo,K.M., M.L. Cunningham, M.L. Snell, R.A. Herbert, G.S. Travlos, S.R. Eldridge, and J.R. Bucher 14-Week Toxicity and Cell Proliferation of Methyleugenol Administered by Gavage to F344 Rats and B6C3F1 Mice 2001; TITLE=14-Week Toxicity and Cell Proliferation of Methyleugenol Administered by Gavage to F344 Rats and B6C3F1 Mice; AUTHOR=Abdo,K.M., M.L. Cunningham, M.L. Snell, R.A. Herbert, G.S. Travlos, S.R. Eldridge, and J.R. Bucher; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=81553; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2001; ORIGINAL_YEAR=2001; TOXICOLOGICAL_EFFECT=Serum gastrin decrease; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry; STUDY_GROUP=ECOTOX:15613273:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=56e4091cbb9de88eb2c5fdff4de14dbe |
| ToxValDB_ECOTOX | LOEL | =9 | mg/kg bw/day | Mouse | oral | short-term; 30 days | short-term | LONG_REF=- | Food Chem. Toxicol.39(4): 303-316 Abdo,K.M., M.L. Cunningham, M.L. Snell, R.A. Herbert, G.S. Travlos, S.R. Eldridge, and J.R. Bucher 14-Week Toxicity and Cell Proliferation of Methyleugenol Administered by Gavage to F344 Rats and B6C3F1 Mice 2001; TITLE=14-Week Toxicity and Cell Proliferation of Methyleugenol Administered by Gavage to F344 Rats and B6C3F1 Mice; AUTHOR=Abdo,K.M., M.L. Cunningham, M.L. Snell, R.A. Herbert, G.S. Travlos, S.R. Eldridge, and J.R. Bucher; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=81553; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2001; ORIGINAL_YEAR=2001; TOXICOLOGICAL_EFFECT=Cell proliferation as indicated by BrdU labeling index: gastric pits, pylorus; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX:15613541:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=24fa0f0fd6bd217ee28e75348d7aeb30 |
| ToxValDB_ECOTOX | NOEL | =10000 | ppm | Rat | oral | short-term; 15 days | short-term | LONG_REF=Toxicol. Appl. Pharmacol.19(1): 54-61 Wagstaff,D.J., and C.R. Short Induction of Hepatic Microsomal Hydroxylating Enzymes by Technical Piperonyl Butoxide and Some of Its Analogs 1971; TITLE=Induction of Hepatic Microsomal Hydroxylating Enzymes by Technical Piperonyl Butoxide and Some of Its Analogs; AUTHOR=Wagstaff,D.J., and C.R. Short; DOI=10.1016/0041-008x(71)90189-x; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=81452; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1971; ORIGINAL_YEAR=1971; TOXICOLOGICAL_EFFECT=Feeding behavior: Food consumption; TOXICOLOGICAL_EFFECT_CATEGORY=food and/or water consumption; STUDY_GROUP=ECOTOX_dup_EPA ORD_15608602_15608603:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=c600d5ffd9f81712a712dbfd1f0d395e |
| ToxValDB_ECOTOX | NOEL | =100 | mg/kg bw/day | Mouse | injection | short-term; 29 days | short-term | LONG_REF=Pharmacology14(4): 367-377 Sell,A.B., and E.A. Carlini Anesthetic Action of Methyleugenol and Other Eugenol Derivatives 1976; TITLE=Anesthetic Action of Methyleugenol and Other Eugenol Derivatives; AUTHOR=Sell,A.B., and E.A. Carlini; DOI=10.1159/000136617; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=81555; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1976; ORIGINAL_YEAR=1976; TOXICOLOGICAL_EFFECT=Growth: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECOTOX:15609926:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=9dad21f553414d662604f82d4f7056b9 |
ToxValDB_GESTIS_DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_GESTIS_DNEL | DNEL systemic | =9.87 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15629600:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9229472a901cd23174c82f68619241d4 |
ToxValDB_ToxRefDB 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ToxRefDB | LEL | =30 | mg/kg bw/day | Mouse | oral | chronic; 14 weeks | chronic | LONG_REF=NTP_2000_Toxicology and Carcinogenesis Studies of Methyleugenol (CAS NO. 93-15-2) in F344/N Rats and B6C3F1 Mice (Gavage Studies)_Subchronic_Mice; TITLE=Toxicology and Carcinogenesis Studies of Methyleugenol (CAS NO. 93-15-2) in F344/N Rats and B6C3F1 Mice (Gavage Studies)_Subchronic_Mice; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5482; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2000; ORIGINAL_YEAR=2000; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-stomach-degeneration|systemic: pathology microscopic-stomach-mitotic alteration|systemic: pathology microscopic-stomach-cyst|systemic: pathology microscopic-liver-necrosis|systemic: in life observation-mortality-mortality|systemic: pathology microscopic-liver-inflammation|systemic: pathology microscopic-stomach-edema|systemic: in life observation-body weight-body weight gain|systemic: organ weight-liver-relative to body weight|systemic: pathology microscopic-stomach-atrophy|systemic: organ weight-liver-absolute|systemic: pathology microscopic-liver-hyperplasia|systemic: pathology microscopic-liver-cytologic alterations|systemic: pathology microscopic-stomach-necrosis|systemic: pathology gross-liver-discolored|systemic: pathology gross-liver-enlarged; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|gross pathology|mortality/survival|nonneoplastic histopathology|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15709349_15709350_15709351_15709352:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_640a7fa48a8b3626033b21ad095e45b8 |
| ToxValDB_ToxRefDB | LOAEL | =300 | mg/kg bw/day | Mouse | oral | chronic; 14 weeks | chronic | LONG_REF=NTP_2000_Toxicology and Carcinogenesis Studies of Methyleugenol (CAS NO. 93-15-2) in F344/N Rats and B6C3F1 Mice (Gavage Studies)_Subchronic_Mice; TITLE=Toxicology and Carcinogenesis Studies of Methyleugenol (CAS NO. 93-15-2) in F344/N Rats and B6C3F1 Mice (Gavage Studies)_Subchronic_Mice; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5482; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2000; ORIGINAL_YEAR=2000; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-liver-necrosis|systemic: pathology microscopic-liver-inflammation|systemic: pathology microscopic-stomach-degeneration|systemic: pathology microscopic-stomach-mitotic alteration|systemic: pathology microscopic-stomach-edema|systemic: in life observation-body weight-body weight gain|systemic: organ weight-liver-relative to body weight|systemic: pathology microscopic-stomach-atrophy|systemic: organ weight-liver-absolute|systemic: pathology microscopic-liver-hyperplasia|systemic: pathology microscopic-stomach-cyst|systemic: pathology microscopic-liver-cytologic alterations; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|nonneoplastic histopathology|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15709349_15709350_15709351_15709352:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_edb123c2d2ec0f7bdac9c907f1c338bf |
| ToxValDB_ToxRefDB | LOAEL | =75 | mg/kg bw/day | Rat | oral | chronic; 105 weeks | chronic | LONG_REF=NTP_2000_Toxicology and Carcinogenesis Studies of Methyleugenol (CAS NO. 93-15-2) in F344/N Rats and B6C3F1 Mice (Gavage Studies)_Chronic_Rats; TITLE=Toxicology and Carcinogenesis Studies of Methyleugenol (CAS NO. 93-15-2) in F344/N Rats and B6C3F1 Mice (Gavage Studies)_Chronic_Rats; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5484; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2000; ORIGINAL_YEAR=2000; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-stomach-hyperplasia|systemic: pathology gross-liver-discolored|systemic: in life observation-body weight-body weight|systemic: pathology gross-stomach-mass|systemic: pathology gross-liver-mass|systemic: pathology microscopic-liver-hypertrophy|systemic: pathology gross-stomach-thickened|systemic: pathology microscopic-stomach-atrophy|systemic: pathology microscopic-liver-eosinophilic focus|systemic: pathology microscopic-liver-hyperplasia|systemic: pathology gross-liver-nodule(s); TOXICOLOGICAL_EFFECT_CATEGORY=body weight|gross pathology|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15709356_15709357_15709358:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5cc2251329cc5befe03cbb4e19268295 |
| ToxValDB_ToxRefDB | NOAEL | =100 | mg/kg bw/day | Rat | oral | chronic; 14 weeks | chronic | LONG_REF=NTP_2000_Toxicology and Carcinogenesis Studies of Methyleugenol (CAS NO. 93-15-2) in F344/N Rats and B6C3F1 Mice (Gavage Studies)_Subchronic_Rats; TITLE=Toxicology and Carcinogenesis Studies of Methyleugenol (CAS NO. 93-15-2) in F344/N Rats and B6C3F1 Mice (Gavage Studies)_Subchronic_Rats; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5481; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2000; ORIGINAL_YEAR=2000; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-salivary glands-cytoplasmic alteration|systemic: clinical chemistry-alanine aminotransferase (alt/sgpt)-alanine aminotransferase (alt/sgpt)|systemic: clinical chemistry-bile acids-bile acids|systemic: organ weight-thymus-relative to body weight|systemic: in life observation-body weight-body weight gain|systemic: pathology microscopic-liver-cytomegaly|systemic: pathology microscopic-liver-mixed cell focus|systemic: pathology microscopic-stomach-atrophy|systemic: hematology-mean corpuscular hemoglobin (mch)-mean corpuscular hemoglobin (mch)|systemic: pathology gross-liver-foci|systemic: hematology-hematocrit (hct)-hematocrit (hct)|systemic: pathology microscopic-stomach-inflammation|systemic: in life observation-body weight-body weight|systemic: pathology microscopic-uterus-atrophy|systemic: clinical chemistry-creatinine-creatinine|systemic: organ weight-thymus-absolute|systemic: in life observation-clinical signs-urine staining - perineum|systemic: hematology-hemoglobin (hgb)-hemoglobin (hgb)|systemic: hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|systemic: pathology gross-uterus-reduced size|systemic: clinical chemistry-sorbitol dehydrogenase-sorbitol dehydrogenase|systemic: pathology microscopic-liver-hyperplasia|systemic: in life observation-clinical signs-emaciation|systemic: organ weight-liver-relative to body weight|systemic: pathology gross-uterus-thinning|systemic: clinical chemistry-protein-protein|systemic: pathology microscopic-liver-pigmentation|systemic: clinical chemistry-albumin-albumin|systemic: hematology-platelet-platelet|systemic: organ weight-liver-absolute|systemic: pathology microscopic-liver-cytologic alterations|systemic: pathology microscopic-adrenal gland-hypertrophy; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|clinical signs|gross pathology|hematology|nonneoplastic histopathology|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15709343_15709344_15709345:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_760c6d875d3295231eb4280e866b7741 |
openFDA substances 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | 29T9VA6R7M | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C11H14O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"29T9VA6R7M"} |
| openFDA substances | FDA UNII substance identifier | 29T9VA6R7M | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C11H14O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"29T9VA6R7M"} |
| openFDA substances | FDA UNII substance identifier | 29T9VA6R7M | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C11H14O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"29T9VA6R7M"} |
| openFDA substances | FDA UNII substance identifier | 29T9VA6R7M | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C11H14O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"29T9VA6R7M"} |