Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Expert Verdict
CIR Expert Panel concluded the entire Glycyrrhetinic Acid / Glycyrrhizic Acid family (including Methyl Glycyrrhizate) is safe as used in cosmetics. Glycyrrhizic Acid is cytotoxic at high doses when ingested, but dermal absorption is poor. Not an irritant, sensitizer, phototoxic agent, or photosensitizer at current use concentrations.. Derived from licorice root (Glycyrrhiza species). Known for anti-inflammatory and soothing properties characteristic of glycyrrhizic acid derivatives. The methy...
Regulatory Flags
Frequently Asked Questions
Is Methyl Glycyrrhizate safe in cosmetics?
CIR Expert Panel concluded the entire Glycyrrhetinic Acid / Glycyrrhizic Acid family (including Methyl Glycyrrhizate) is safe as used in cosmetics. Glycyrrhizic Acid is cytotoxic at high doses when ingested, but dermal absorption is poor. Not an irritant, sensitizer, phototoxic agent, or photosensitizer at current use concentrations.. Derived from licorice root (Glycyrrhiza species). Known for anti-inflammatory and soothing properties characteristic of glycyrrhizic acid derivatives. The methy... The EU classifies Methyl Glycyrrhizate as "permitted". Safety rating: MODERATE.
Is Methyl Glycyrrhizate allowed in the EU?
Methyl Glycyrrhizate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Methyl Glycyrrhizate do in cosmetics?
Methyl Glycyrrhizate functions as: Skin conditioning - reduces flaking, restores suppleness to dry or damaged skin. Also used as a flavoring agent in lip products.. It is classified as a cosmetic ingredient in our database. CAS number: 104191-95-9..
What is the Margin of Safety for Methyl Glycyrrhizate?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
Compliance Tools
Check Methyl Glycyrrhizate compliance across multiple jurisdictions:
Related Ingredients
Is Methyl Glycyrrhizate in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Methyl Glycyrrhizate in your formulation.