Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
3 study endpoints found for Methyl Isoeugenol. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 6 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 264 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| dose_tested | 6 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
Expert Verdict
Skin sensitization/allergen potential; structurally related to isoeugenol (a well-documented sensitizer with max 0.02% limit). 1,2-dimethoxy-4-propenylbenzene structure; IFRA and EU 1223/2009 compliant at appropriate use levels; spicy-floral character used in oriental and carnation accords
Regulatory Flags
Frequently Asked Questions
Is Methyl Isoeugenol safe in cosmetics?
Skin sensitization/allergen potential; structurally related to isoeugenol (a well-documented sensitizer with max 0.02% limit). 1,2-dimethoxy-4-propenylbenzene structure; IFRA and EU 1223/2009 compliant at appropriate use levels; spicy-floral character used in oriental and carnation accords The EU classifies Methyl Isoeugenol as "prohibited". Safety rating: MODERATE. 3 toxicological study endpoint(s) are available in our database.
Is Methyl Isoeugenol allowed in the EU?
Methyl Isoeugenol EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Methyl Isoeugenol do in cosmetics?
Methyl Isoeugenol functions as: Fragrance - spicy, clove-like, warm floral scent. It is classified as a cosmetic ingredient in our database. CAS number: 93-16-3.
What is the Margin of Safety for Methyl Isoeugenol?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Methyl Isoeugenol?
The NOAEL (No Observed Adverse Effect Level) for Methyl Isoeugenol is 6 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 3 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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