Methyl Perfluoro Butyl/Isobutyl Ether

INCI: METHYL PERFLUOROBUTYL ETHER (THE COMMERCIAL MIXTURE IS TYPICALLY LISTED UNDER THIS NAME, AS IT CONTAINS BOTH ISOMERS)

CAS Number
163702-07-6 (covers the commercial mixture of n-butyl and isobutyl isomers)
Function
Solvent, Viscosity Controlling Agent
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Allowed but flagged as a PFAS ingredient in cosmetics. Under MoCRA Section 3(9), FDA was mandated to assess PFAS safety in cosmetics and publish findings by December 29, 2025.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Classified as a non-polymer PFAS; environmental persistence is the primary concern. Bioaccumulation potential is considered lower than long-chain PFAS but still under active regulatory evaluation.. Volatile fluorinated ether; non-flammable; commercially known as 3M Novec 7100 Engineered Fluid; provides a unique lightweight, fast-evaporating sensory profile

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Concern Level: Moderate

Frequently Asked Questions

Is Methyl Perfluoro Butyl/Isobutyl Ether safe in cosmetics?

Classified as a non-polymer PFAS; environmental persistence is the primary concern. Bioaccumulation potential is considered lower than long-chain PFAS but still under active regulatory evaluation.. Volatile fluorinated ether; non-flammable; commercially known as 3M Novec 7100 Engineered Fluid; provides a unique lightweight, fast-evaporating sensory profile The EU classifies Methyl Perfluoro Butyl/Isobutyl Ether as "permitted". Safety rating: MODERATE.

Is Methyl Perfluoro Butyl/Isobutyl Ether allowed in the EU?

Methyl Perfluoro Butyl/Isobutyl Ether EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Methyl Perfluoro Butyl/Isobutyl Ether do in cosmetics?

Methyl Perfluoro Butyl/Isobutyl Ether functions as: Solvent, Viscosity Controlling Agent. It is classified as a cosmetic ingredient in our database. CAS number: 163702-07-6 (covers the commercial mixture of n-butyl and isobutyl isomers).

What is the Margin of Safety for Methyl Perfluoro Butyl/Isobutyl Ether?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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