Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for Methyl Phenylbutanol. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOEL | 500 mg/kg bw/day | dermal | rat | dermal | REACH |
| NOEL | 500 mg/kg bw/day | dermal | - | dermal | REACH |
Expert Verdict
Generally low concern at typical fragrance use levels. Standard sensitization and irritation profile for tertiary alcohol fragrance ingredients.. Synthetic origin; tertiary alcohol structure provides stability; typical fragrance concentrations range from 0.2-1% in skin/hair products and up to 15-30% in fine fragrances
Regulatory Flags
Frequently Asked Questions
Is Methyl Phenylbutanol safe in cosmetics?
Generally low concern at typical fragrance use levels. Standard sensitization and irritation profile for tertiary alcohol fragrance ingredients.. Synthetic origin; tertiary alcohol structure provides stability; typical fragrance concentrations range from 0.2-1% in skin/hair products and up to 15-30% in fine fragrances The EU classifies Methyl Phenylbutanol as "permitted". Safety rating: MODERATE. 2 toxicological study endpoint(s) are available in our database.
Is Methyl Phenylbutanol allowed in the EU?
Methyl Phenylbutanol EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Methyl Phenylbutanol do in cosmetics?
Methyl Phenylbutanol functions as: Fragrance. It is classified as a cosmetic ingredient in our database. CAS number: 103-05-9.
What is the Margin of Safety for Methyl Phenylbutanol?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Methyl Phenylbutanol?
The NOAEL (No Observed Adverse Effect Level) for Methyl Phenylbutanol is 500 mg/kg bw/day based on a dermal study via dermal route in rat. A total of 2 study endpoints are available. Source: REACH.
Compliance Tools
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Related Ingredients
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