Methyl Thioglycolate

INCI: METHYL THIOGLYCOLATE

CAS Number
2365-48-2
Function
Depilatory agent / hair waving agent (reducing agent that breaks disulfide bonds in keratin)
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status prohibited
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Allowed with labeling requirements. FDA requires adequate directions for use and caution statements on depilatory and hair waving products.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Skin and eye irritant; can cause chemical burns at improper pH/concentration; allergic contact dermatitis reported; strong unpleasant sulfurous odor.. Ester of methanol and thioglycolic acid; acts by cleaving keratin disulfide bonds; requires strict pH control (typically pH 7-12.7 depending on product type).

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Concern Level: Moderate

Frequently Asked Questions

Is Methyl Thioglycolate safe in cosmetics?

Skin and eye irritant; can cause chemical burns at improper pH/concentration; allergic contact dermatitis reported; strong unpleasant sulfurous odor.. Ester of methanol and thioglycolic acid; acts by cleaving keratin disulfide bonds; requires strict pH control (typically pH 7-12.7 depending on product type). The EU classifies Methyl Thioglycolate as "prohibited". Safety rating: MODERATE.

Is Methyl Thioglycolate allowed in the EU?

Methyl Thioglycolate EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.

What does Methyl Thioglycolate do in cosmetics?

Methyl Thioglycolate functions as: Depilatory agent / hair waving agent (reducing agent that breaks disulfide bonds in keratin). It is classified as a cosmetic ingredient in our database. CAS number: 2365-48-2.

What is the Margin of Safety for Methyl Thioglycolate?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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