Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for Methylal. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOEL | ca.2000 2285 | 1995 | rat | inhalation | REACH |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Expert Verdict
Highly flammable; may release formaldehyde on hydrolysis; potential sensitizer via formaldehyde release. Very volatile (bp ~42 °C); excellent solvent power for resins and polymers; low viscosity
Regulatory Flags
Frequently Asked Questions
Is Methylal safe in cosmetics?
Highly flammable; may release formaldehyde on hydrolysis; potential sensitizer via formaldehyde release. Very volatile (bp ~42 °C); excellent solvent power for resins and polymers; low viscosity The EU classifies Methylal as "restricted". Safety rating: MODERATE. 1 toxicological study endpoint(s) are available in our database.
Is Methylal allowed in the EU?
Methylal EU regulatory status: restricted. Maximum allowed concentration: 0.1%. This is based on EU Regulation 1223/2009 and its amendments.
What does Methylal do in cosmetics?
Methylal functions as: Solvent. It is classified as a cosmetic ingredient in our database. CAS number: 109-87-5.
What is the Margin of Safety for Methylal?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Methylal?
The NOAEL (No Observed Adverse Effect Level) for Methylal is ca.2000 2285 based on a inhalation study via 1995 route in rat. Source: REACH.
Is Methylal classified as hazardous under GHS?
Methylal carries a GHS signal word of "DANGER". Hazard statements: Highly flammable liquid and vapour Causes eye irritation May cause drowsiness or dizziness. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.
Compliance Tools
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Related Ingredients
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