Is Miconazole Nitrate safe in cosmetics?
Miconazole Nitrate has a safety rating of "MODERATE" in our database. EU status: permitted. US status: prohibited.
Moderate
Cosmetic Ingredient
Miconazole Nitrate
Also known as: Nitric acid--1-{2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl}-1H-imidazole (1/1), 1H-Imidazole, 1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-, nitrate (1:1), 1H-Imidazole, 1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-, mononitrate, Imidazole, 1-[2,4-dichloro-β-[(2,4-dichlorobenzyl)oxy]phenethyl]-, mononitrate, [2,4-Dichloro-β-(2,4-dichlorobenzyloxy)phenethyl]imidazole nitrate (+15 more)
INCI: MICONAZOLE NITRATE
Miconazole Nitrate (CAS 22832-87-7) is a cosmetic cosmetic ingredient functioning as Antimicrobial - helps control the growth of micro-organisms (bacteria and fungi). EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 22832-87-7 →
Auto-generated CPSR Part A draft with source citations
Function
Antimicrobial - helps control the growth of micro-organisms (bacteria and fungi)
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]imidazole;nitric acid
InChIKey
MCCACAIVAXEFAL-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
prohibited
US Notes
Regulated as an OTC drug active ingredient (antifungal monograph, 21 CFR 333). Use in a cosmetic with antifungal claims would trigger drug classification. Not explicitly prohibited in cosmetics, but any antimicrobial/antifungal claim converts the product to a drug
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Miconazole Nitrate.
Calculate MoS for your specific formulation with the MoS Calculator.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Intermediate
Tonnage Band
Intermediate use only
Substance Type
SUBSTANCE
SVHC Candidate
No
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
Additional Jurisdictional Restrictions (2)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| MY | banned | - | All cosmetic products prohibited |
| MY | banned (immediate) | 0% | All cosmetic products |
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Biocide
Expert Verdict
Expert safety assessment and concern-level summary for Miconazole Nitrate.
Regulatory Flags
potential-allergen
Known Synonyms
Nitric acid--1-{2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl}-1H-imidazole (1/1)
1H-Imidazole, 1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-, nitrate (1:1)
1H-Imidazole, 1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-, mononitrate
Imidazole, 1-[2,4-dichloro-β-[(2,4-dichlorobenzyl)oxy]phenethyl]-, mononitrate
[2,4-Dichloro-β-(2,4-dichlorobenzyloxy)phenethyl]imidazole nitrate
Aflorix
Albistat
Andergin
Brentan
Conoderm
Conofite
Dactrine
Daktarin
Daktarin talc
Deralbine
Dermonistat
Ecobi
Epi-Monistat
Florid
Fungiderm
Chemical Function
Biocide
Regulatory Lists
active_ingredient; Australia
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
MICONAZOLE NITRATE
ChEMBL ID
CHEMBL1559
Max Phase
4
Adverse Event Associations
21
Frequently Asked Questions
Is Miconazole Nitrate allowed in the EU?
Miconazole Nitrate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Miconazole Nitrate do in cosmetics?
Miconazole Nitrate functions as: Antimicrobial - helps control the growth of micro-organisms (bacteria and fungi). It is classified as a cosmetic ingredient in our database. CAS number: 22832-87-7.
Is Miconazole Nitrate used outside cosmetics?
Miconazole Nitrate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Miconazole Nitrate compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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