Mixed Isopropanolamines

INCI: MIXED ISOPROPANOLAMINES

CAS Number
68938-59-0
Function
Buffering agent (pH adjustment)
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status restricted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Allowed with caution; CIR (Cosmetic Ingredient Review) has reviewed isopropanolamine-containing ingredients with conditions related to nitrosamine contamination

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Primary concern is nitrosamine formation - when combined with nitrosating agents, secondary amines can form carcinogenic N-nitrosamines. Must not be used in products containing nitrosating systems. A mixture of mono-, di-, and triisopropanolamine (MIPA, DIPA, TIPA). Functions as a base to neutralize acidic ingredients and adjust formulation pH

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Concern Level: High

Frequently Asked Questions

Is Mixed Isopropanolamines safe in cosmetics?

Primary concern is nitrosamine formation - when combined with nitrosating agents, secondary amines can form carcinogenic N-nitrosamines. Must not be used in products containing nitrosating systems. A mixture of mono-, di-, and triisopropanolamine (MIPA, DIPA, TIPA). Functions as a base to neutralize acidic ingredients and adjust formulation pH The EU classifies Mixed Isopropanolamines as "restricted". Safety rating: MODERATE.

Is Mixed Isopropanolamines allowed in the EU?

Mixed Isopropanolamines EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.

What does Mixed Isopropanolamines do in cosmetics?

Mixed Isopropanolamines functions as: Buffering agent (pH adjustment). It is classified as a cosmetic ingredient in our database. CAS number: 68938-59-0.

What is the Margin of Safety for Mixed Isopropanolamines?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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