NOAEL Studies
UV Filter / Sunscreen
Nano Zinc Oxide NOAEL Studies
INCI: ZINC OXIDE
CAS: 1314-13-2
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
COSMOS DB 10 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| COSMOS DB | NOAEL | 45 | mg/kg bw/day | swine | oral | 14 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 99 | mg/kg bw/day | sheep | oral | 70 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 100 | mg/kg bw/day | swine | oral | 14 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 149 | mg/kg bw/day | cattle | oral | 4 day | Special Toxicology Study | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 164 | mg/kg bw/day | swine | oral | 28 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 172 | mg/kg bw/day | rat | oral | 252 day | Chronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 400 | mg/kg bw/day | rat | oral | 56 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 500 | mg/kg bw/day | rat | oral | 28 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 600 | mg/kg bw/day | rat | oral | 21 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 606 | mg/kg bw/day | rat | oral | 10 day | Special Toxicology Study | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
NTP ICE acute inhalation 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute inhalation | LC50 | >1.79 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=4203; Record_ID=acute_inhalation_1832; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID7035016; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=1.79; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16139/7/3/3/?documentUUID=d5093ff7-b3f3-4595-8fb5-707d8303b2e3; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7035016 |
| NTP ICE acute inhalation | LC50 | >5.7 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=4202; Record_ID=acute_inhalation_1839; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID7035016; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=5.7; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16139/7/3/3/?documentUUID=f0900b38-089f-4db8-a4a5-d11deef9b233; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7035016 |
SCCNFP Opinion 5 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| SCCNFP Opinion | NOAEL | =0.5 | mg/kg/day | human | oral | 6 weeks | NOAEL study | p.7 |
| SCCNFP Opinion | NOAEL | =40 | % | human | oral | developmental | developmental toxicity | Ref. : 29 2, p.14 |
| SCCNFP Opinion | NOAEL | =42.5 | mg/kg | rabbit | oral | developmental | developmental toxicity | p.13 |
| SCCNFP Opinion | NOAEL | =60 | mg/kg | rat | oral | developmental | developmental toxicity | p.14 |
| SCCNFP Opinion | NOAEL | =3000 | ppm | rat | - | - | NOAEL study | p.7 |
SCCS Opinion 15 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| SCCS Opinion | NOAEL | =0.0225 | mg/kg bw/d | human | oral | - | NOAEL study | p.90 |
| SCCS Opinion | NOAEL | =0.166 | mg/kg bw/d | human | oral | - | NOAEL study | p.90 |
| SCCS Opinion | NOAEL | =0.225 | mg/kg bw/day | human | oral | - | NOAEL study | (Reference 44, sub III), p.90 |
| SCCS Opinion | NOAEL | =0.83 | mg/kg bw/d | human | oral | - | NOAEL study | (Reference 44, sub III), p.90 |
| SCCS Opinion | NOAEL | =0.9 | mg/kg/d | human | oral | - | NOAEL study | (Reference 44, sub III), p.90 |
| SCCS Opinion | NOAEL | =1 | mg/kg bw | rat | intravenous | - | repeated dose toxicity | (References: 85, 94, 119), p.86 |
| SCCS Opinion | NOAEL | =1 | - | human | - | - | NOAEL study | p.89 |
| SCCS Opinion | NOAEL | =2 | % | human | oral | 18 days | repeated dose toxicity | p.89 |
| SCCS Opinion | NOAEL | =4 | - | - | inhalation | 90 days | NOAEL study | p.13 |
| SCCS Opinion | NOAEL | =20 | % | human | oral | 18 days | repeated dose toxicity | p.89 |
| SCCS Opinion | NOAEL | =50 | - | mouse | oral | - | NOAEL study | (Reference 44, sub III), p.96 |
| SCCS Opinion | NOAEL | =90 | - | - | inhalation | 90 days | NOAEL study | p.12 |
| SCCS Opinion | NOAEL | =96 | % | - | - | - | NOAEL study | p.13 |
| SCCS Opinion | NOAEL | =1000 | mg/kg | mouse | oral | - | NOAEL study | Reference: AR16), p.29 |
| SCCS Opinion | NOAEL | =1518 | - | - | - | - | NOAEL study | p.13 |
ToxValDB DOE Wildlife Benchmarks 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB DOE Wildlife Benchmarks | LOAEL | =320 | mg/kg bw/day | Rat | oral | - | repeat dose other | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65bd1d53e4b063812d68c240; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://rais.ornl.gov/documents/tm86r3.pdf; STUDY_GROUP=DOE Wildlife Benchmarks_dup_-_15511732_15511733:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3ebf403078a5e913b57b05bc20466670 |
| ToxValDB DOE Wildlife Benchmarks | NOAEL | =160 | mg/kg bw/day | Rat | oral | - | repeat dose other | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65bd1d53e4b063812d68c240; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://rais.ornl.gov/documents/tm86r3.pdf; STUDY_GROUP=DOE Wildlife Benchmarks_dup_-_15511732_15511733:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5842136dc14ffb68cb0f57e51d356058 |
ECHA 12 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ECHA | LEL | =2.5 | mg/m3 | Rat | inhalation | - | acute | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61b61e4b096bca876de2f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/10228/7/3/3?documentUUID=819bf807-93be-4ebf-8cda-44ec703048cc; YEAR=1969; ORIGINAL_YEAR=1969; STUDY_GROUP=ECHA IUCLID:15795745:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ab3ff196fb47d292a28ee1e5d0bcd425 |
| ECHA | LEL | ~4.6 | mg/m3 | Guinea Pig | inhalation | short-term; 6 days | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61fd3e4b096bca877eff6; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/24855/7/6/3?documentUUID=07ed0690-2bf9-419e-8ccc-30c37dab3fe1; YEAR=1977; ORIGINAL_YEAR=1977; STUDY_GROUP=ECHA IUCLID:15827097:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_592f1e6aa088d65cd7c4a8a8d2298d72 |
| ECHA | LEL | =5 | mg/m3 | Rabbit | inhalation | - | acute | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059759e4b063812d6fa6de; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11214/7/3/3?documentUUID=fcaa6bea-650a-413b-94a6-3d002945fc60; YEAR=1982; ORIGINAL_YEAR=1982; STUDY_GROUP=ECHA IUCLID:15796094:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4cd11eedad53117f0d834ca188afbb0c |
| ECHA | LEL | =7.8 | mg/m3 | Guinea Pig | inhalation | - | acute | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059759e4b063812d6fa6de; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/10329/7/3/3?documentUUID=9335e422-4b04-439e-b32c-4a913c2da116; YEAR=2013; ORIGINAL_YEAR=2013; STUDY_GROUP=ECHA IUCLID_dup_Acute Toxicity Inhalation_15795975_15796897:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_084b71e7b0617cdc7e06127d20f0ba17 |
| ECHA | LEL | ~731 | ppm | Sheep | oral | short-term; 14 days | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cb96e4b0a7c65d226a94; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/24962/7/6/2?documentUUID=dfc1dee8-bb78-4fd3-b706-372ddde549af; YEAR=1996; ORIGINAL_YEAR=1996; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15830373_15832877_15836688_15840371_15842751_15843448_15845544:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1af5230e229d1c877d2660e0a369d87a |
| ECHA | LOAEL | =125 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eadc7e4b0a7c65d1c5fc5; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/10329/7/6/2?documentUUID=9335e422-4b04-439e-b32c-4a913c2da116; YEAR=2013; ORIGINAL_YEAR=2013; TOXICOLOGICAL_EFFECT=histopathology: nonneoplastic; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15847227_15847468_15848640_15848676_15848947_15848951_15850702_15850703_15850704_15850705_15850706_15850707_15850708_15850709_15850710_15850711_15850712_15850713:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_00676d649c76c64849dab92425be8636 |
| ECHA | NOAEC | =1.96 | mg/m3 | Rat | inhalation | short-term; 10 days | short-term | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61fa0e4b096bca877e312; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13376/7/6/3?documentUUID=1bb64f22-9e4c-4f54-991f-a093ab5588fc; YEAR=2008; ORIGINAL_YEAR=2008; STUDY_GROUP=ECHA IUCLID:15826939:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b860d08df8e8c7b27c1804413734155f |
| ECHA | NOAEC | =7.5 | mg/m3 | Rat | inhalation | - | developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d215e4b0a7c65d2316a1; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1803/7/9/3?documentUUID=93089a17-9c2c-4eaf-8903-70c9beb87b12; YEAR=2018; ORIGINAL_YEAR=2018; TOXICOLOGICAL_EFFECT=fetus: changes in sex ratio|fetus: fetal/pup body weight changes|fetus: changes in litter size and weights|fetus: external malformations|fetus: skeletal malformations|fetus: visceral malformations; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15820793_15821376_15821531_15821592_15821667:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_128fb7ffc5b43921d687956bec6ca77a |
| ECHA | NOAEL | =31.25 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cbd8e4b0a7c65d227c5d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/25400/7/6/2?documentUUID=a83e3d7f-2fc0-4f85-bebd-551b8cb28c3f; YEAR=2020; ORIGINAL_YEAR=2020; TOXICOLOGICAL_EFFECT=haematology|histopathology: non-neoplastic|organ weights and organ / body weight ratios; TOXICOLOGICAL_EFFECT_CATEGORY=hematology|nonneoplastic histopathology|organ weight; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15847227_15847468_15848640_15848676_15848947_15848951_15850702_15850703_15850704_15850705_15850706_15850707_15850708_15850709_15850710_15850711_15850712_15850713:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_88dff0c829a2181d0ba79bfeaabe8612 |
| ECHA | NOAEL | =200 | mg/kg bw/day | Rat | oral | - | developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac6ee4b0a7c65d1bf122; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14696/7/9/3?documentUUID=e1d3e977-4ed0-49fc-861b-0d67daaf4fde; YEAR=1995; ORIGINAL_YEAR=1995; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15820650_15820651_15820673_15820985_15820993_15821730_15824230_15824231_15824232_15824233_15824234_15824235:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_70077948745acaa946b78013c60e2d4a |
| ECHA | NOAEL | ~240 | mg/kg bw/day | Sheep | oral | short-term; 28 days | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cc1ae4b0a7c65d228eec; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11214/7/6/2?documentUUID=fcaa6bea-650a-413b-94a6-3d002945fc60; YEAR=1982; ORIGINAL_YEAR=1982; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15831592_15833010_15836300_15838074_15839691_15841330_15845352:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_336b101d3d234b9fe42a8f72b142f3c3 |
| ECHA | NOAEL | =400 | mg/kg bw/day | Rat | oral | - | developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabe9e4b0a7c65d1bc68a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13376/7/9/3?documentUUID=1bb64f22-9e4c-4f54-991f-a093ab5588fc; YEAR=2008; ORIGINAL_YEAR=2008; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15820650_15820651_15820673_15820985_15820993_15821730_15824230_15824231_15824232_15824233_15824234_15824235:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_000740ca595654ca7a18084b25335caa |
ToxValDB ECOTOX 15 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB ECOTOX | LOEL | =0.4 | % | Rat | oral | short-term; 20 days | reproduction developmental | LONG_REF=J. Nutr.95:287-294 Schlicker,S.A., and D.H. Cox Maternal Dietary Zinc, and Development and Zinc, Iron, and Copper Content of the Rat Fetus 1968; TITLE=Maternal Dietary Zinc, and Development and Zinc, Iron, and Copper Content of the Rat Fetus; AUTHOR=Schlicker,S.A., and D.H. Cox; DOI=10.1093/jn/95.2.287; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=68036; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1968; ORIGINAL_YEAR=1968; TOXICOLOGICAL_EFFECT=Accumulation: Residue|Biochemistry: Copper (Cu) content|Growth: Weight|Morphology: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594320_15597202:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=7e8a1f7aef69ecae9e6ec42af42e1af0 |
| ToxValDB ECOTOX | LOEL | =4.8 | mg/kg bw/day | Rat | oral | subchronic; 42 days | subchronic | LONG_REF=- | Nutr. Res.20(3): 413-425 Subramanian,P., S. Sivabalan, V.P. Menon, and K. Vasudevan Influence of Chronic Zinc Supplementation on Biochemical Variables and Circadian Rhythms in Wistar Rats 2000; TITLE=Influence of Chronic Zinc Supplementation on Biochemical Variables and Circadian Rhythms in Wistar Rats; AUTHOR=Subramanian,P., S. Sivabalan, V.P. Menon, and K. Vasudevan; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=68812; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2000; ORIGINAL_YEAR=2000; TOXICOLOGICAL_EFFECT=Biochemistry: Iron content|Biochemistry: Thiobarbituric acid reactive substances|Enzyme(s): Ceruloplasmin activity; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|enzyme activity|other; STUDY_GROUP=ECOTOX:15613045:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=2b51eee8eaf3867c51cf8a88986f58f1 |
| ToxValDB ECOTOX | LOEL | =31.2 | mg/kg bw/day | Rat | oral | chronic; 120 days | chronic | LONG_REF=Int. J. Vitam. Nutr. Res.56:329-337 Shankar,S., P.R. Sundaresan, and S. Mohla Effect of Chronic Administration of Excess Dietary Vitamin A and Zinc on Lipid Metabolism in Rats 1986; TITLE=Effect of Chronic Administration of Excess Dietary Vitamin A and Zinc on Lipid Metabolism in Rats; AUTHOR=Shankar,S., P.R. Sundaresan, and S. Mohla; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=79334; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1986; ORIGINAL_YEAR=1986; TOXICOLOGICAL_EFFECT=Accumulation: Residue|Biochemistry: Cholesterol|Biochemistry: Total lipids|Biochemistry: Vitamin A; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15595646_15596056:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=6bfe6812185848bb5fd44df8c4e3238f |
| ToxValDB ECOTOX | LOEL | =1000 | ppm | Rat | oral | short-term; 10 days | short-term | LONG_REF=J. Nutr. Biochem.15(4): 206-209 Szabo,J., M. Hegedus, G. Bruckner, E. Kosa, E. Andrasofszky, and E. Berta Large Doses of Zinc Oxide Increases the Activity of Hydrolases in Rats 2004; TITLE=Large Doses of Zinc Oxide Increases the Activity of Hydrolases in Rats; AUTHOR=Szabo,J., M. Hegedus, G. Bruckner, E. Kosa, E. Andrasofszky, and E. Berta; DOI=10.1016/j.jnutbio.2003.09.005; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=100797; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2004; ORIGINAL_YEAR=2004; TOXICOLOGICAL_EFFECT=Enzyme(s): Amylase|Enzyme(s): Lipase|Enzyme(s): Protease|Enzyme(s): Trypsin; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|enzyme activity; STUDY_GROUP=ECOTOX:15595835:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=3bf0813b6a9b87a9152c2545dfb01d7d |
| ToxValDB ECOTOX | LOEL | =1200 | ppm | Rat | oral | short-term; 21 days | short-term | LONG_REF=Proc. Soc. Exp. Biol. Med.152:192-194 Ansari,M.S., W.J. Miller, M.W. Neathery, J.W. Lassiter, R.P. Gentry, and R.L. Kincaid Zinc Metabolism and Homeostasis in Rats Fed a Wide Range of High Dietary Zinc Levels 1976; TITLE=Zinc Metabolism and Homeostasis in Rats Fed a Wide Range of High Dietary Zinc Levels; AUTHOR=Ansari,M.S., W.J. Miller, M.W. Neathery, J.W. Lassiter, R.P. Gentry, and R.L. Kincaid; DOI=10.3181/00379727-152-39358; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=68021; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1976; ORIGINAL_YEAR=1976; TOXICOLOGICAL_EFFECT=Accumulation: Residue; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15596631_15601911_15603183_15603184_15610362_15610363:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=f348fe139df36d6e82744086bb1c8a09 |
| ToxValDB ECOTOX | LOEL | =2400 | ppm | Rat | oral | short-term; 21 days | short-term | LONG_REF=Proc. Soc. Exp. Biol. Med.152:192-194 Ansari,M.S., W.J. Miller, M.W. Neathery, J.W. Lassiter, R.P. Gentry, and R.L. Kincaid Zinc Metabolism and Homeostasis in Rats Fed a Wide Range of High Dietary Zinc Levels 1976; TITLE=Zinc Metabolism and Homeostasis in Rats Fed a Wide Range of High Dietary Zinc Levels; AUTHOR=Ansari,M.S., W.J. Miller, M.W. Neathery, J.W. Lassiter, R.P. Gentry, and R.L. Kincaid; DOI=10.3181/00379727-152-39358; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=68021; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1976; ORIGINAL_YEAR=1976; TOXICOLOGICAL_EFFECT=Accumulation: Residue; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15596631_15601911_15603183_15603184_15610362_15610363:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=0bdf651349b67c89989a3353b736f777 |
| ToxValDB ECOTOX | LOEL | =6010 | ppm | Mouse | oral | short-term; 10 days | short-term | LONG_REF=Am. J. Vet. Res.56(3): 334-339 Zhang,P., G.E. Duhamel, J.V. Mysore, M.P. Carlson, and N.R. Schneider Prophylactic Effect of Dietary Zinc in a Laboratory Mouse Model of Swine Dysentery 1995; TITLE=Prophylactic Effect of Dietary Zinc in a Laboratory Mouse Model of Swine Dysentery; AUTHOR=Zhang,P., G.E. Duhamel, J.V. Mysore, M.P. Carlson, and N.R. Schneider; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=86644; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1995; ORIGINAL_YEAR=1995; TOXICOLOGICAL_EFFECT=Accumulation: Residue; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX:15597911:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=3d7064d679e5547a417477d10b588e85 |
| ToxValDB ECOTOX | NOEL | =0.2 | % | Rat | oral | short-term; 23 days | reproduction developmental | LONG_REF=J. Nutr.98:303-311 Ketcheson,M.R., G.P. Barron, and D.H. Cox Relationship of Maternal Dietary Zinc During Gestation and Lactation to Development and Zinc, Iron and Copper Content of the Postnatal Rat 1969; TITLE=Relationship of Maternal Dietary Zinc During Gestation and Lactation to Development and Zinc, Iron and Copper Content of the Postnatal Rat; AUTHOR=Ketcheson,M.R., G.P. Barron, and D.H. Cox; DOI=10.1093/jn/98.3.303; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=78356; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1969; ORIGINAL_YEAR=1969; TOXICOLOGICAL_EFFECT=Biochemistry: Copper (Cu) content|Biochemistry: Iron content|Growth: Weight|Morphology: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15595307_15595308_15595309_15599517:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=820fd639219c01a602809f6447952547 |
| ToxValDB ECOTOX | NOEL | =0.5 | % | Rat | oral | short-term; 23 days | reproduction developmental | LONG_REF=J. Nutr.98:303-311 Ketcheson,M.R., G.P. Barron, and D.H. Cox Relationship of Maternal Dietary Zinc During Gestation and Lactation to Development and Zinc, Iron and Copper Content of the Postnatal Rat 1969; TITLE=Relationship of Maternal Dietary Zinc During Gestation and Lactation to Development and Zinc, Iron and Copper Content of the Postnatal Rat; AUTHOR=Ketcheson,M.R., G.P. Barron, and D.H. Cox; DOI=10.1093/jn/98.3.303; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=78356; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1969; ORIGINAL_YEAR=1969; TOXICOLOGICAL_EFFECT=Biochemistry: Copper (Cu) content|Biochemistry: Iron content|Feeding behavior: Food consumption|Morphology: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=food and/or water consumption|other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15595307_15595308_15595309_15599517:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=596aacdcd28c9a2288e4a05b7b0cb9f4 |
| ToxValDB ECOTOX | NOEL | =20 | % w/v | Mouse | dermal | short-term; 5 days | short-term | LONG_REF=Food Chem. Toxicol.29(1): 57-64 Lansdown,A.B.G. Interspecies Variations in Response to Topical Application of Selected Zinc Compounds 1991; TITLE=Interspecies Variations in Response to Topical Application of Selected Zinc Compounds; AUTHOR=Lansdown,A.B.G.; DOI=10.1016/0278-6915(91)90063-d; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=85721; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1991; ORIGINAL_YEAR=1991; TOXICOLOGICAL_EFFECT=Genetics: Mitotic index (# mitoses/total cells); TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX:15609914:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=1eaae6dcf15a303ca8c96864ec24098b |
| ToxValDB ECOTOX | NOEL | =97.46 | ppm | Rat | oral | short-term; 17 days | developmental | LONG_REF=Toxicology126:9-21 Bui,L.M., M.W. Taubeneck, J.F. Commisso, J.Y. Uriu-Hare, W.D. Faber, and C.L. Keen Altered Zinc Metabolism Contributes to the Developmental Toxicity of 2-Ethylhexanoic Acid, 2-Ethylhexanol and Valproic Acid 1998; TITLE=Altered Zinc Metabolism Contributes to the Developmental Toxicity of 2-Ethylhexanoic Acid, 2-Ethylhexanol and Valproic Acid; AUTHOR=Bui,L.M., M.W. Taubeneck, J.F. Commisso, J.Y. Uriu-Hare, W.D. Faber, and C.L. Keen; DOI=10.1016/s0300-483x(97)00171-6; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=67778; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1998; ORIGINAL_YEAR=1998; TOXICOLOGICAL_EFFECT=Accumulation: Residue|Biochemistry: Metallothionein|Development: Abnormal|Development: Slowed, Retarded, Delayed or Non-development|Development: Weight|Growth: Weight gain|Histology: Hernia|Injury: Hydrocephaly|Morphology: Length|Reproduction: Resorbed embryos; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|development|gross pathology|other|reproduction; STUDY_GROUP=ECOTOX:15597812:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=8ccaedbbc98616953ee2fae6f0e079aa |
| ToxValDB ECOTOX | NOEL | =160 | mg/kg bw/day | Rat | multiple | short-term; 7 days | short-term | LONG_REF=Br. J. Nutr.57(1): 35-44 Coppen,D.E., and N.T. Davies Studies on the Effects of Dietary Zinc Dose on 65Zn Absorption In Vivo and on the Effects of Zn Status on 65Zn Absorption and Body Loss in Young Rats 1987; TITLE=Studies on the Effects of Dietary Zinc Dose on 65Zn Absorption In Vivo and on the Effects of Zn Status on 65Zn Absorption and Body Loss in Young Rats; AUTHOR=Coppen,D.E., and N.T. Davies; DOI=10.1079/bjn19870007; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=68815; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1987; ORIGINAL_YEAR=1987; TOXICOLOGICAL_EFFECT=Growth: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECOTOX:15594936:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=eef87ceb15d5156136369a42c6f74a52 |
| ToxValDB ECOTOX | NOEL | =200 | ppm | Rat | oral | short-term; 21 days | short-term | LONG_REF=Toxicol. Appl. Pharmacol.84:12-24 Agarwal,D.K., S. Eustis, J.C. Lamb IV, C.W. Jameson, and W.M. Kluwe Influence of Dietary Zinc on Di(2-ethylhexyl)Phthalate-Induced Testicular Atrophy and Zinc Depletion in Adult Rats 1986; TITLE=Influence of Dietary Zinc on Di(2-ethylhexyl)Phthalate-Induced Testicular Atrophy and Zinc Depletion in Adult Rats; AUTHOR=Agarwal,D.K., S. Eustis, J.C. Lamb IV, C.W. Jameson, and W.M. Kluwe; DOI=10.1016/0041-008x(86)90412-6; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=67779; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1986; ORIGINAL_YEAR=1986; TOXICOLOGICAL_EFFECT=Accumulation: Residue|Biochemistry: Cholesterol|Biochemistry: Sulfhydryl|Biochemistry: Triglycerides|Enzyme(s): Lactate dehydrogenase|Growth: Weight|Histology: Atrophy|Morphology: Organ weight in relationship to body weight|Morphology: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|nonneoplastic histopathology|organ weight|other; STUDY_GROUP=ECOTOX:15594126:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=6adb079de583dee0dd1b140c8a0a1359 |
| ToxValDB ECOTOX | NOEL | =7200 | ppm | Rat | oral | short-term; 21 days | short-term | LONG_REF=Proc. Soc. Exp. Biol. Med.152:192-194 Ansari,M.S., W.J. Miller, M.W. Neathery, J.W. Lassiter, R.P. Gentry, and R.L. Kincaid Zinc Metabolism and Homeostasis in Rats Fed a Wide Range of High Dietary Zinc Levels 1976; TITLE=Zinc Metabolism and Homeostasis in Rats Fed a Wide Range of High Dietary Zinc Levels; AUTHOR=Ansari,M.S., W.J. Miller, M.W. Neathery, J.W. Lassiter, R.P. Gentry, and R.L. Kincaid; DOI=10.3181/00379727-152-39358; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=68021; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1976; ORIGINAL_YEAR=1976; TOXICOLOGICAL_EFFECT=Accumulation: Residue; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15596631_15601911_15603183_15603184_15610362_15610363:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=c5f39ca3364f03cd73d7afff30a2f997 |
| ToxValDB ECOTOX | NOEL | =8400 | ppm | Rat | oral | short-term; 21 days | short-term | LONG_REF=Proc. Soc. Exp. Biol. Med.152:192-194 Ansari,M.S., W.J. Miller, M.W. Neathery, J.W. Lassiter, R.P. Gentry, and R.L. Kincaid Zinc Metabolism and Homeostasis in Rats Fed a Wide Range of High Dietary Zinc Levels 1976; TITLE=Zinc Metabolism and Homeostasis in Rats Fed a Wide Range of High Dietary Zinc Levels; AUTHOR=Ansari,M.S., W.J. Miller, M.W. Neathery, J.W. Lassiter, R.P. Gentry, and R.L. Kincaid; DOI=10.3181/00379727-152-39358; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=68021; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1976; ORIGINAL_YEAR=1976; TOXICOLOGICAL_EFFECT=Accumulation: Residue|Feeding behavior: Food consumption|Growth: Weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption|other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15596631_15601911_15603183_15603184_15610362_15610363:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=1a641f8969fcb6476372432011151f6f |
ToxValDB GESTIS DNEL 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB GESTIS DNEL | DNEL local | =0.5 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15635797_15635798:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0afe08211dcb59355f05b2290e8737f9 |
| ToxValDB GESTIS DNEL | DNEL systemic | =5 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15635797_15635798:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_828b69a487421f7fe32e65e2f03a0056 |
ToxValDB NIOSH IDLH 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB NIOSH IDLH | LEL | =320 | mg/m3 | Human | inhalation | acute; 3 hours | occupational | LONG_REF=Hammond JW [1944]. Metal fume fever in the crushed stone industry. J Ind Hyg Toxicol 26(4):117-119.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c9b384e4b02565fc7d7211; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.cdc.gov/niosh/idlh/; SUBSOURCE_URL=https://www.cdc.gov/niosh/idlh/1314132.html; YEAR=1994; ORIGINAL_YEAR=1994; TOXICOLOGICAL_EFFECT=nausea on the job, and chills, shortness of breath, and severe chest pains 2 to 12 hours later; STUDY_GROUP=NIOSH IDLH:15953833:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_ceb47f03f2e0fa564077f3be3b8daa9a |
| ToxValDB NIOSH IDLH | LEL | =600 | mg/m3 | Human | inhalation | acute; 12 minutes | clinical | LONG_REF=Sturgis CC, Thompson PD [1927]. Metal fume fever: I. Clinical observations on the effect of the experimental inhalation of zinc oxide by two apparently normal persons. J Ind Hyg 9(3):88-97.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c9b384e4b02565fc7d7211; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.cdc.gov/niosh/idlh/; SUBSOURCE_URL=https://www.cdc.gov/niosh/idlh/1314132.html; YEAR=1994; ORIGINAL_YEAR=1994; TOXICOLOGICAL_EFFECT=headaches, chills, and fever with cough and a decrease in vital capacity which persisted for 15 hours after exposure; STUDY_GROUP=NIOSH IDLH:15953834:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_1e81bfe7ebdea3f6cc59db87bd89c690 |
Regulatory source 25 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| Regulatory source | - | 0.5 | mg/kg/day | human | oral | 6 weeks | - | p.7 |
| Regulatory source | - | 3000 | ppm | rat | - | - | - | p.7 |
| Regulatory source | - | 3000 | ppm | rat | oral | - | - | p.7 |
| Regulatory source | developmental toxicity | 40 | % | human | oral | developmental | developmental toxicity | p.14 |
| Regulatory source | developmental toxicity | 42.5 | mg/kg | rabbit | oral | developmental | developmental toxicity | p.13 |
| Regulatory source | developmental toxicity | 60 | mg/kg | rat | oral | developmental | developmental toxicity | p.14 |
| Regulatory source | - | 0.0225 | mg/kg bw/d | human | oral | - | - | p.90 |
| Regulatory source | - | 0.166 | mg/kg bw/d | human | oral | - | - | p.90 |
| Regulatory source | - | =0.166 | mg /kg bw | human | oral | - | - | p.90 |
| Regulatory source | - | 0.225 | mg/kg bw/day | human | oral | - | - | p.90 |
| Regulatory source | - | 0.83 | mg/kg bw/d | human | oral | - | - | p.90 |
| Regulatory source | - | =0.83 | mg /kg bw | human | oral | - | - | p.90 |
| Regulatory source | - | 0.9 | mg/kg/d | human | oral | - | - | p.90 |
| Regulatory source | - | 1 | - | human | - | - | - | p.89 |
| Regulatory source | - | 4 | - | - | inhalation | 90 days | - | p.13 |
| Regulatory source | - | 20 | % | human | oral | - | - | p.89 |
| Regulatory source | - | 50 | - | mouse | oral | - | - | p.96 |
| Regulatory source | - | 90 | - | - | inhalation | 90 days | - | p.12 |
| Regulatory source | - | 96 | % | - | - | - | - | p.13 |
| Regulatory source | - | 1000 | mg/kg | mouse | oral | - | - | p.29 |
| Regulatory source | - | 1518 | - | - | - | - | - | p.13 |
| Regulatory source | repeated dose toxicity | 1 | mg/kg bw | rat | intravenous | - | repeated dose toxicity | p.86 |
| Regulatory source | repeated dose toxicity | 2 | % | human | oral | 18 days | repeated dose toxicity | p.89 |
| Regulatory source | repeated dose toxicity | 20 | % | human | oral | 18 days | repeated dose toxicity | p.89 |
| Regulatory source | repeated dose toxicity | 20 | % | human | oral | - | repeated dose toxicity | p.89 |
openFDA substances 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | SOI2LOH54Z | UNII | - | - | - | chemical | - |