Nano Zinc Oxide
INCI: ZINC OXIDE
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Nano Zinc Oxide. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 606 mg/kg bw/day | oral | rat | Special Toxicology Study | COSMOS_DB |
| NOAEL | 600 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 500 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 400 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 400 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 172 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
| NOAEL | 500 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 99 mg/kg bw/day | oral | sheep | Short Term Toxicity | COSMOS_DB |
| NOAEL | 149 mg/kg bw/day | oral | cattle | Special Toxicology Study | COSMOS_DB |
| NOAEL | 45 mg/kg bw/day | oral | swine | Short Term Toxicity | COSMOS_DB |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Sensitization Profile
Contact sensitization data for Nano Zinc Oxide based on clinical patch test studies and IFRA standards.
Source: ESSCA 2019/20; NACDG 2021-22
Dermal Penetration Profile
Skin absorption and penetration characteristics of Nano Zinc Oxide, relevant to systemic exposure and MoS calculations.
Source: SCCS/1518/13
Expert Verdict
Nano Zinc Oxide is generally considered safe for use as a mineral broadband UV filter protecting skin against both UVA and UVB radiation.
Regulatory Flags
Frequently Asked Questions
Is Nano Zinc Oxide safe in cosmetics?
Nano Zinc Oxide is generally considered safe for use as a mineral broadband UV filter protecting skin against both UVA and UVB radiation. The EU classifies Nano Zinc Oxide as "restricted". Safety rating: GOOD. 10 toxicological study endpoint(s) are available in our database.
Is Nano Zinc Oxide allowed in the EU?
Nano Zinc Oxide EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does Nano Zinc Oxide do in cosmetics?
Nano Zinc Oxide functions as: UV Filter. It is classified as a UV Filter / Sunscreen in our database. CAS number: 1314-13-2.
What is the Margin of Safety for Nano Zinc Oxide?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Nano Zinc Oxide?
The NOAEL (No Observed Adverse Effect Level) for Nano Zinc Oxide is 606 mg/kg bw/day based on a Special Toxicology Study study via oral route in rat. A total of 10 study endpoints are available. Source: COSMOS_DB.
Is Nano Zinc Oxide classified as hazardous under GHS?
Nano Zinc Oxide carries a GHS signal word of "WARNING". Hazard statements: Very toxic to aquatic life with long lasting effects. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.
Compliance Tools
Check Nano Zinc Oxide compliance across multiple jurisdictions:
Related Ingredients
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