Is NISIN safe in cosmetics?
NISIN has a safety rating of "GOOD" in our database. EU status: permitted. US status: allowed.
Good
Cosmetic Ingredient
NISIN
Also known as: Microgard MG 300, Nisitrol, Novasin, Ambicin N, Delvoplus (+7 more)
NISIN (CAS 1414-45-5) is a cosmetic cosmetic ingredient functioning as Antimicrobial. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 1414-45-5 →
Auto-generated CPSR Part A draft with source citations
Function
Antimicrobial
Safety Rating
GOOD
Regulatory Status
EU EU Status
permitted
US US Status
allowed
US Notes
GRAS (Generally Recognized As Safe) as a food preservative; in cosmetics, allowed subject to general safety substantiation
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Additional Ingredient Properties
4 property records from structured ingredient metadata.
deodorant
{"cas_number": "1414-45-5", "ingredient_class": "antimicrobial_deodorant", "mechanism_of_action": "bacterial_growth_inhibition", "antiperspirant_efficacy_sweat_reduction_pct": "0", "deodorant_efficacy_hours": "12-24", "odor_reduction_pct": "50-70", "bacteriostatic": "yes", "bactericidal": "yes", "target_bacteria": "broad_spectrum", "microbiome_impact": "selective", "axillary_microbiome_effect": "v…
fermentation
{"cas_number": "varies", "ingredient_class": "microbial_metabolite", "production_organism": "bacteria", "fermentation_type": "aerobic", "substrate_feedstock": "glucose, amino acids", "bioactive_compounds_produced": "Nisin", "mechanism_of_action_skin": "cell signaling, antimicrobial, antioxidant, metabolic regulation", "skin_benefit_primary": "antioxidant", "skin_benefit_secondary": "anti_inflammat…
microbiome
{"cas_number": "1414-45-5", "ingredient_class": "bacteriocin", "microbial_source_genus": "Lactococcus", "microbial_source_species": "lactis", "fermentation_substrate": "milk", "live_organism_content": "no", "bioactive_components": "bacteriocins/peptides", "molecular_weight_range_Da": "3353", "pH_of_ingredient": "5.5-7.0", "mechanism_of_action": "AMP_production/biofilm_disruption", "skin_microbiome…
preservative
{"preservative_class": "Antimicrobial peptide", "antimicrobial_spectrum_bacteria_gp": "Excellent", "antimicrobial_spectrum_bacteria_gn": "Weak", "antimicrobial_spectrum_yeast": "Weak", "antimicrobial_spectrum_mold": "Weak", "mic_staph_aureus_ppm": "20", "mic_e_coli_ppm": "5000", "mic_pseudomonas_ppm": "5000", "mic_candida_albicans_ppm": "3000", "mic_aspergillus_niger_ppm": "4000", "challenge_test_…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Biocide
Expert Verdict
Expert safety assessment and concern-level summary for NISIN.
Regulatory Flags
cosing-sourced
eu-permitted
preservative
needs-enrichment
Known Synonyms
Microgard MG 300
Nisitrol
Novasin
Ambicin N
Delvoplus
E 234
L-Lysine, L-isoleucyl-(Z)-2,3-didehydro-2-aminobutanoyl-D-cysteinyl-L-isoleucyl-2,3-didehydroalanyl-L-leucyl-L-cysteinyl-threo-3-mercapto-D-2-aminobutanoyl-L-prolylglycyl-L-cysteinyl-L-lysyl-threo-3-mercapto-D-2-aminobutanoylglycyl-L-alanyl-L-leucyl-L-methionylglycyl-L-cysteinyl-L-asparaginyl-L-methionyl-L-lysyl-threo-3-mercapto-D-2-aminobutanoyl-L-alanyl-threo-3-mercapto-D-2-aminobutanoyl-L-cysteinyl-L-histidyl-L-cysteinyl-L-seryl-L-isoleucyl-L-histidyl-L-valyl-2,3-didehydroalanyl-, cyclic (3→7),(8→11),(13→19),(23→26),(25→28)-pentakis(sulfide)
Nisaplin
Nisin A
Nisin(1-34)
nisina
nisine
Chemical Function
Biocide
Australian Status
AICIS status: listed
Frequently Asked Questions
Is NISIN allowed in the EU?
NISIN EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does NISIN do in cosmetics?
NISIN functions as: Antimicrobial. It is classified as a cosmetic ingredient in our database. CAS number: 1414-45-5.
Compliance Tools
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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