Is NISIN safe in cosmetics?
NISIN has a safety rating of "GOOD" in our database. EU status: permitted. US status: allowed.
GOOD
Cosmetic Ingredient
NISIN
Also known as: Microgard MG 300, Nisitrol, Novasin, Ambicin N, Delvoplus (+7 more)
NISIN (CAS 1414-45-5) is a cosmetic cosmetic ingredient functioning as Antimicrobial. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in food safety data.
Function
Antimicrobial
Editorial assessment
GOOD
Preliminary editorial note — not a computed safety verdict.
Regulatory Status
EU EU Status
permitted
US US Status
allowed
US Notes
GRAS (Generally Recognized As Safe) as a food preservative; in cosmetics, allowed subject to general safety substantiation
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Biocide
Editorial summary
Preliminary editorial summary for NISIN — not a computed safety verdict. See the sourced toxicological data above.
Regulatory Flags
cosing-sourced
eu-permitted
preservative
needs-enrichment
Known Synonyms
Microgard MG 300
Nisitrol
Novasin
Ambicin N
Delvoplus
E 234
L-Lysine, L-isoleucyl-(Z)-2,3-didehydro-2-aminobutanoyl-D-cysteinyl-L-isoleucyl-2,3-didehydroalanyl-L-leucyl-L-cysteinyl-threo-3-mercapto-D-2-aminobutanoyl-L-prolylglycyl-L-cysteinyl-L-lysyl-threo-3-mercapto-D-2-aminobutanoylglycyl-L-alanyl-L-leucyl-L-methionylglycyl-L-cysteinyl-L-asparaginyl-L-methionyl-L-lysyl-threo-3-mercapto-D-2-aminobutanoyl-L-alanyl-threo-3-mercapto-D-2-aminobutanoyl-L-cysteinyl-L-histidyl-L-cysteinyl-L-seryl-L-isoleucyl-L-histidyl-L-valyl-2,3-didehydroalanyl-, cyclic (3→7),(8→11),(13→19),(23→26),(25→28)-pentakis(sulfide)
Nisaplin
Nisin A
Nisin(1-34)
nisina
nisine
Chemical Function
Biocide
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in food safety data.
SOURCE
EFSA / FDA GRAS
food_additives + fda_gras_enriched
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
Nisin
E Number
E234
FDA GRAS
FDA has no questions
GRN
65
Food Category
preservative
Use on casings for frankfurters and on cooked meat and poultry products as an antimicrobial agent
View full food safety profile →Frequently Asked Questions
Is NISIN allowed in the EU?
NISIN EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does NISIN do in cosmetics?
NISIN functions as: Antimicrobial. It is classified as a cosmetic ingredient in our database. CAS number: 1414-45-5.
Is NISIN used outside cosmetics?
NISIN also appears in food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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