Good Cosmetic Ingredient NOAEL Data

NONAN-2-ONE

CAS Number
821-55-6
Function
Perfuming
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status Permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status prohibited
US Notes Allowed โ€” not prohibited or restricted; also has FEMA GRAS status for flavoring, reinforcing its safety profile

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Toxicological Studies

4 study endpoints found for NONAN-2-ONE. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 1000 mg/kg bw/day oral rat oral REACH
LOAEL 2000 mg/kg bw/day oral rat oral REACH
NOAEL >2000 mg/kg bw/day oral rat oral REACH
NOAEL 1000 mg/kg bw/day oral rat oral REACH

Expert Verdict

NONAN-2-ONE is listed in the EU CosIng database with functions: Perfuming It is permitted in the EU without specific restrictions.

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Concern Level: Low

Regulatory Flags

cosing-sourced eu-permitted fragrance needs-enrichment ifra_fragrance fda_food_additive

Frequently Asked Questions

Is NONAN-2-ONE safe in cosmetics?

NONAN-2-ONE is listed in the EU CosIng database with functions: Perfuming It is permitted in the EU without specific restrictions. The EU classifies NONAN-2-ONE as "Permitted". Safety rating: GOOD. 4 toxicological study endpoint(s) are available in our database.

Is NONAN-2-ONE allowed in the EU?

NONAN-2-ONE EU regulatory status: Permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does NONAN-2-ONE do in cosmetics?

NONAN-2-ONE functions as: Perfuming. It is classified as a cosmetic ingredient in our database. CAS number: 821-55-6.

What is the NOAEL for NONAN-2-ONE?

The NOAEL (No Observed Adverse Effect Level) for NONAN-2-ONE is 1000 mg/kg bw/day based on a oral study via oral route in rat. A total of 4 study endpoints are available. Source: REACH.

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