Is NOOTKATONE safe in cosmetics?
NOOTKATONE has a safety rating of "GOOD" in our database. EU status: permitted. US status: allowed.
GOOD
Cosmetic Ingredient
NOOTKATONE
Also known as: (+)-Nootkatone, 2(3H)-Naphthalenone, 4,4a,5,6,7,8-hexahydro-4,4a-dimethyl-6-(1-methylethenyl)-, (4R,4aS,6R)-, (4R-(4alpha,4aalpha,6beta))-4,4a,5,6,7,8-Hexahydro-4,4a-dimethyl-6-(1-methylvinyl)naphthalen-2(3H)-one, 5,6-Dimethyl-8-isopropenylbicyclo(4.4.0)dec-1-en-3-one, 4a,5-Dimethyl-1,2,3,4,4a,5,6,7-octahydro-7-keto-3-isopropenylnaphthalene (+9 more)
NOOTKATONE (CAS 4674-50-4) is a cosmetic cosmetic ingredient functioning as Perfuming. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety, pharmaceutical, and food safety data.
Function
Perfuming
Editorial assessment
GOOD
Preliminary editorial note — not a computed safety verdict.
Chemistry & Identifiers
IUPAC Name
(4R,4aS,6R)-4,4a-dimethyl-6-prop-1-en-2-yl-3,4,5,6,7,8-hexahydronaphthalen-2-one
InChIKey
WTOYNNBCKUYIKC-JMSVASOKSA-N
Regulatory Status
EU EU Status
permitted
US US Status
allowed
US Notes
Allowed; also an FDA-approved food additive (FEMA 3166) and EPA-registered biopesticide
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Sensitization AOP Dashboard
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
NESIL
6750 µg/cm²
GHS: 1B
Human: positive
Source: HPPT: [591] RIFM (1977): RIFM report number 1702, June 6, unpublished.
HRIPT Human Patch Test Studies
3 human repeat insult patch tests aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 6750 | - | - |
| HMT | - | 0 | 6750 | - | - |
| HMT | - | 0 | 6750 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (2)
JECFA Number
1398
Source: WHO/JECFA
JECFA Evaluation
NOOTKATONE | 2004 | No safety concern at current levels of intake when used as a flavouring agent | TRS 928-JECFA 63/86 | FAS 54-JECFA 63/385
Source: WHO/JECFA
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (3)
IFRA Fragrance Transparency List
EPA Safer Chemical Ingredients List (SCIL)
FDA Substances Added to Food (EAFUS)
Editorial summary
Preliminary editorial summary for NOOTKATONE — not a computed safety verdict. See the sourced toxicological data above.
Regulatory Flags
cosing-sourced
eu-permitted
fragrance
needs-enrichment
epa_safer_alternative
ifra_fragrance
fda_food_additive
jecfa_safe
Known Synonyms
(+)-Nootkatone
2(3H)-Naphthalenone, 4,4a,5,6,7,8-hexahydro-4,4a-dimethyl-6-(1-methylethenyl)-, (4R,4aS,6R)-
(4R-(4alpha,4aalpha,6beta))-4,4a,5,6,7,8-Hexahydro-4,4a-dimethyl-6-(1-methylvinyl)naphthalen-2(3H)-one
5,6-Dimethyl-8-isopropenylbicyclo(4.4.0)dec-1-en-3-one
4a,5-Dimethyl-1,2,3,4,4a,5,6,7-octahydro-7-keto-3-isopropenylnaphthalene
EINECS 225-124-4
1(10),11-Eremophiladien-2-one
4Betah,5alpha-eremophila-1(10),11-dien-2-one
4betaH,5alpha-Eremorphila-1(10)11-dien-2-one
FEMA No. 3166
4,4a,5,6,7,8-Hexahydro-4,4a-dimethyl-6-(1-methylethenyl)-2(3H)-naphthalenone, (4R-(4alpha,4aalpha,6beta))-
4,4a,5,6,7,8-Hexahydro-6-isopropenyl-4,4a-dimethyl-2(3H)-naphthalenone
2(3H)-Naphthalenone, 4,4a,5,6,7,8-hexahydro-4,4a-dimethyl-6-(1-methylethenyl)-, (4R-(4alpha,4aalpha,6beta))-
UNII-IZ2Y119N4J
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
IFRA Transparency
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
SCIL (9/2019)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical and food safety data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
NOOTKATONE
ChEMBL ID
CHEMBL446299
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
NOOTKATONE
ADI
No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
Food Category
flavoring
Frequently Asked Questions
Is NOOTKATONE allowed in the EU?
NOOTKATONE EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does NOOTKATONE do in cosmetics?
NOOTKATONE functions as: Perfuming. It is classified as a cosmetic ingredient in our database. CAS number: 4674-50-4.
Is NOOTKATONE used outside cosmetics?
NOOTKATONE also appears in industrial chemical safety, pharmaceutical, and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check NOOTKATONE compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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