Octoxynol-40

CAS Number
9002-93-1
Function
Surfactant (surface active agent)
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted โ€” CIR: safe as used. Also FDA-approved inactive ingredient in ophthalmic solutions at โ‰ค 0.05% w/v

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
negligible
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Residual EO and 1,4-dioxane present; environmental ED degradation product; most robust toxicological dataset in the family including chronic oral and sub-chronic studies; not COSMOS/ECOCERT eligible

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Concern Level: Low

Regulatory Flags

ifra_fragrance fda_food_additive

Frequently Asked Questions

Is Octoxynol-40 safe in cosmetics?

Residual EO and 1,4-dioxane present; environmental ED degradation product; most robust toxicological dataset in the family including chronic oral and sub-chronic studies; not COSMOS/ECOCERT eligible The EU classifies Octoxynol-40 as "permitted". Safety rating: GOOD.

Is Octoxynol-40 allowed in the EU?

Octoxynol-40 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Octoxynol-40 do in cosmetics?

Octoxynol-40 functions as: Surfactant (surface active agent). It is classified as a cosmetic ingredient in our database. CAS number: 9002-93-1.

What is the Margin of Safety for Octoxynol-40?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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