Good Cosmetic Ingredient NOAEL Data

p-Cresyl Methylether

INCI: P-CRESYL METHYL ETHER

CAS Number
104-93-8
Function
Fragrance ingredient
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes FDA FEMA 2681; general cosmetic use permitted

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

6 study endpoints found for p-Cresyl Methylether. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 120 mg/kg bw/day oral rat Short Term Toxicity COSMOS_DB
NOEL 100 mg/kg bw/day oral rat oral REACH
NOAEL 40 mg/kg bw/day oral rat oral REACH
NOAEL 100 mg/kg bw/day oral rat oral REACH
NOEL 100 mg/kg bw/day oral rat oral REACH
NOAEL 40 mg/kg bw/day oral rat oral REACH

Expert Verdict

Stable ether that does not readily hydrolyze to p-cresol under physiological conditions. No significant safety concerns at typical use levels.

⚠️
Concern Level: Low

Regulatory Flags

fragrance-component ifra_fragrance fda_food_additive

Frequently Asked Questions

Is p-Cresyl Methylether safe in cosmetics?

Stable ether that does not readily hydrolyze to p-cresol under physiological conditions. No significant safety concerns at typical use levels. The EU classifies p-Cresyl Methylether as "permitted". Safety rating: GOOD. 6 toxicological study endpoint(s) are available in our database.

Is p-Cresyl Methylether allowed in the EU?

p-Cresyl Methylether EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does p-Cresyl Methylether do in cosmetics?

p-Cresyl Methylether functions as: Fragrance ingredient. It is classified as a cosmetic ingredient in our database. CAS number: 104-93-8.

What is the Margin of Safety for p-Cresyl Methylether?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for p-Cresyl Methylether?

The NOAEL (No Observed Adverse Effect Level) for p-Cresyl Methylether is 120 mg/kg bw/day based on a Short Term Toxicity study via oral route in rat. A total of 6 study endpoints are available. Source: COSMOS_DB.

Compliance Tools

Check p-Cresyl Methylether compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
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