Good Cosmetic Ingredient Dermal Penetration

PANTETHINE

CAS Number
16816-67-4
Function
Hair Conditioning, Skin Conditioning - Emollient
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status Permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status prohibited
US Notes Allowed โ€” not prohibited or restricted

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Dermal Penetration Profile

Skin absorption and penetration characteristics of PANTETHINE, relevant to systemic exposure and MoS calculations.

Absorption %
5-10%
Penetration Level
stratum-corneum
Penetration Depth
stratum corneum/epidermis
Molecular Weight
278.4 Da
Log P
-1.5
Systemic Absorption
minimal
Topical Bioavailability
3-8%
Safety Margin Factor
low
Vehicle Dependent
Yes โ€” absorption varies by formulation

Source: Cosmetic Science

Expert Verdict

PANTETHINE is listed in the EU CosIng database with functions: Hair Conditioning, Skin Conditioning - Emollient It is permitted in the EU without specific restrictions.

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Concern Level: Low

Regulatory Flags

cosing-sourced eu-permitted skin-conditioning hair-conditioning emollient needs-enrichment

Frequently Asked Questions

Is PANTETHINE safe in cosmetics?

PANTETHINE is listed in the EU CosIng database with functions: Hair Conditioning, Skin Conditioning - Emollient It is permitted in the EU without specific restrictions. The EU classifies PANTETHINE as "Permitted". Safety rating: GOOD.

Is PANTETHINE allowed in the EU?

PANTETHINE EU regulatory status: Permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does PANTETHINE do in cosmetics?

PANTETHINE functions as: Hair Conditioning, Skin Conditioning - Emollient. It is classified as a cosmetic ingredient in our database. CAS number: 16816-67-4.

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