Good Cosmetic Ingredient NOAEL Data

PEG-20 SORBITAN OLEATE

CAS Number
9005-65-6
Function
Cleansing, Surfactant - Cleansing, Surfactant - Emulsifying
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status Permitted
🇺🇸 US Status allowed
US Notes Allowed — also FDA-approved as a food additive (21 CFR 172.840) and pharmaceutical excipient, reflecting extensive safety evaluation.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Toxicological Studies

10 study endpoints found for PEG-20 SORBITAN OLEATE. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 5000 mg/kg bw/day oral rat Chronic COSMOS_DB
NOAEL 1000 mg/kg bw/day oral monkey Subchronic COSMOS_DB
NOAEL 1000 mg/kg bw/day oral rat Chronic COSMOS_DB
NOAEL 10000 mg/kg bw/day oral rat Multigeneration Reproductive COSMOS_DB
NOAEL 1000 mg/kg bw/day oral rat Subchronic COSMOS_DB
NOAEL 5000 mg/kg bw/day oral rat Short Term Toxicity COSMOS_DB
NOAEL 7500 mg/kg bw/day oral mouse Short Term Toxicity COSMOS_DB
NOAEL 2500 mg/kg bw/day oral rat Subchronic COSMOS_DB
NOAEL 7500 mg/kg bw/day oral mouse Subchronic COSMOS_DB
NOAEL 2500 mg/kg bw/day oral rat Chronic COSMOS_DB

Expert Verdict

PEG-20 SORBITAN OLEATE is listed in the EU CosIng database with functions: Cleansing, Surfactant - Cleansing, Surfactant - Emulsifying It is permitted in the EU without specific restrictions.

⚠️
Concern Level: Low

Regulatory Flags

cosing-sourced eu-permitted surfactant needs-enrichment epa_safer_alternative ifra_fragrance fda_food_additive

Frequently Asked Questions

Is PEG-20 SORBITAN OLEATE safe in cosmetics?

PEG-20 SORBITAN OLEATE is listed in the EU CosIng database with functions: Cleansing, Surfactant - Cleansing, Surfactant - Emulsifying It is permitted in the EU without specific restrictions. The EU classifies PEG-20 SORBITAN OLEATE as "Permitted". Safety rating: GOOD. 10 toxicological study endpoint(s) are available in our database.

Is PEG-20 SORBITAN OLEATE allowed in the EU?

PEG-20 SORBITAN OLEATE EU regulatory status: Permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does PEG-20 SORBITAN OLEATE do in cosmetics?

PEG-20 SORBITAN OLEATE functions as: Cleansing, Surfactant - Cleansing, Surfactant - Emulsifying. It is classified as a cosmetic ingredient in our database. CAS number: 9005-65-6.

What is the NOAEL for PEG-20 SORBITAN OLEATE?

The NOAEL (No Observed Adverse Effect Level) for PEG-20 SORBITAN OLEATE is 5000 mg/kg bw/day based on a Chronic study via oral route in rat. A total of 10 study endpoints are available. Source: COSMOS_DB.

Compliance Tools

Check PEG-20 SORBITAN OLEATE compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
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