PEG-450
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Toxicological Studies
10 study endpoints found for PEG-450. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 1690 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
| NOAEL | 2000 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
| NOAEL | 1820 mg/kg bw/day | oral | dog | Chronic | COSMOS_DB |
| NOAEL | 1600 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 4050 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 230 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 7500 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 10900 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 1128 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 25000 mg/kg bw/day | oral | mouse | Short Term Toxicity | COSMOS_DB |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Expert Verdict
PEG-450 is listed in the EU CosIng database with functions: Binding, Emulsion Stabilising, Solvent It is permitted in the EU without specific restrictions.
Regulatory Flags
Frequently Asked Questions
Is PEG-450 safe in cosmetics?
PEG-450 is listed in the EU CosIng database with functions: Binding, Emulsion Stabilising, Solvent It is permitted in the EU without specific restrictions. The EU classifies PEG-450 as "Permitted". Safety rating: GOOD. 10 toxicological study endpoint(s) are available in our database.
Is PEG-450 allowed in the EU?
PEG-450 EU regulatory status: Permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does PEG-450 do in cosmetics?
PEG-450 functions as: Binding, Emulsion Stabilising, Solvent. It is classified as a cosmetic ingredient in our database. CAS number: 25322-68-3.
What is the NOAEL for PEG-450?
The NOAEL (No Observed Adverse Effect Level) for PEG-450 is 1690 mg/kg bw/day based on a Chronic study via oral route in rat. A total of 10 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
Check PEG-450 compliance across multiple jurisdictions:
Related Ingredients
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