Good Cosmetic Ingredient NOAEL Data GHS Classified

PEG-800

CAS Number
25322-68-3
Function
Anticaking, binding, humectant
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes CIR-reviewed — safe in current practices of use and concentration

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
negligible
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

10 study endpoints found for PEG-800. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 1690 mg/kg bw/day oral rat Chronic COSMOS_DB
NOAEL 2000 mg/kg bw/day oral rat Chronic COSMOS_DB
NOAEL 1820 mg/kg bw/day oral dog Chronic COSMOS_DB
NOAEL 1600 mg/kg bw/day oral rat Subchronic COSMOS_DB
NOAEL 4050 mg/kg bw/day oral rat Subchronic COSMOS_DB
NOAEL 230 mg/kg bw/day oral rat Subchronic COSMOS_DB
NOAEL 7500 mg/kg bw/day oral rat Subchronic COSMOS_DB
NOAEL 10900 mg/kg bw/day oral rat Subchronic COSMOS_DB
NOAEL 1128 mg/kg bw/day oral rat Subchronic COSMOS_DB
NOAEL 25000 mg/kg bw/day oral mouse Short Term Toxicity COSMOS_DB

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Expert Verdict

1,4-Dioxane residual must be controlled via purification

⚠️
Concern Level: Low

Regulatory Flags

peg-ingredient eu_children_restricted epa_safer_alternative ifra_fragrance fda_food_additive

Frequently Asked Questions

Is PEG-800 safe in cosmetics?

1,4-Dioxane residual must be controlled via purification The EU classifies PEG-800 as "permitted". Safety rating: GOOD. 10 toxicological study endpoint(s) are available in our database.

Is PEG-800 allowed in the EU?

PEG-800 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does PEG-800 do in cosmetics?

PEG-800 functions as: Anticaking, binding, humectant. It is classified as a cosmetic ingredient in our database. CAS number: 25322-68-3.

What is the Margin of Safety for PEG-800?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for PEG-800?

The NOAEL (No Observed Adverse Effect Level) for PEG-800 is 1690 mg/kg bw/day based on a Chronic study via oral route in rat. A total of 10 study endpoints are available. Source: COSMOS_DB.

Compliance Tools

Check PEG-800 compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
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Substance Compliance
Check compliance across 55 jurisdictions
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
 ⚗️
Heavy Metal Limits
Compare limits across jurisdictions

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