Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for Permethrin. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 5 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
| LOAEL | 25 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Expert Verdict
Neurotoxic pyrethroid with suspected endocrine disruption properties, classified as EPA Group C possible carcinogen, highly toxic to cats and aquatic organisms, and prohibited in cosmetics in the EU.
Regulatory Flags
Frequently Asked Questions
Is Permethrin safe in cosmetics?
Neurotoxic pyrethroid with suspected endocrine disruption properties, classified as EPA Group C possible carcinogen, highly toxic to cats and aquatic organisms, and prohibited in cosmetics in the EU. The EU classifies Permethrin as "prohibited". Safety rating: POOR. 2 toxicological study endpoint(s) are available in our database.
Is Permethrin allowed in the EU?
Permethrin EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Permethrin do in cosmetics?
Permethrin functions as: Insecticide / acaricide. It is classified as a cosmetic ingredient in our database. CAS number: 52645-53-1.
What is the Margin of Safety for Permethrin?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Permethrin?
The NOAEL (No Observed Adverse Effect Level) for Permethrin is 5 mg/kg bw/day based on a Chronic study via oral route in rat. A total of 2 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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