Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for Calcium Pyrophosphate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 30 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| dose_tested | 30 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
Expert Verdict
Particle size should be controlled in abrasive applications to avoid mechanical irritation.
Regulatory Flags
Frequently Asked Questions
Is Calcium Pyrophosphate safe in cosmetics?
Particle size should be controlled in abrasive applications to avoid mechanical irritation. The EU classifies Calcium Pyrophosphate as "permitted". Safety rating: EXCELLENT. 2 toxicological study endpoint(s) are available in our database.
Is Calcium Pyrophosphate allowed in the EU?
Calcium Pyrophosphate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Calcium Pyrophosphate do in cosmetics?
Calcium Pyrophosphate functions as: Abrasive, oral care agent. It is classified as a cosmetic ingredient in our database. CAS number: 7790-76-3.
What is the Margin of Safety for Calcium Pyrophosphate?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Calcium Pyrophosphate?
The NOAEL (No Observed Adverse Effect Level) for Calcium Pyrophosphate is 30 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 2 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
Check Calcium Pyrophosphate compliance across multiple jurisdictions:
Related Ingredients
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