Is Calcium Pyrophosphate safe in cosmetics?
Calcium Pyrophosphate has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted. 1 toxicological study endpoint(s) are available in our database.
Calcium Pyrophosphate
Also known as: Diphosphoric acid, calcium salt (1:2), C 54-80, Calcium diphosphate (Ca2P2O7), Calcium metaphosphate oxide (Ca0.67(PO3)0.66O0.34), Calcium phosphate (Ca2P2O7) (+8 more)
INCI: CALCIUM PYROPHOSPHATE
Calcium Pyrophosphate (CAS 7790-76-3) is a cosmetic cosmetic ingredient functioning as Abrasive, oral care agent. NOAEL 30 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and food safety data.
View industrial chemical safety profile for CAS 7790-76-3 →
Auto-generated CPSR Part A draft with source citations
Function
Abrasive, oral care agent
Safety Rating
EXCELLENT
Chemistry & Identifiers
IUPAC Name
dicalcium;phosphonato phosphate
InChIKey
JUNWLZAGQLJVLR-UHFFFAOYSA-J
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Adequate per CIR assessment
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Calcium Pyrophosphate.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for Calcium Pyrophosphate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 30 mg/kg bw/day | oral | rat | Subchronic | COSMOS DB |
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Calcium Pyrophosphate across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Additional Ingredient Properties
1 property record from structured ingredient metadata.
mineral_clay
{"cas_number": "7790-76-3", "ingredient_class": "calcium_compound", "chemical_formula": "Ca2P2O7", "mineral_origin": "synthetic", "particle_size_range_um": "1-15", "surface_area_m2_per_g": "10-40", "crystal_structure": "triclinic", "color_appearance": "white", "opacity": "opaque", "refractive_index": "1.65", "oil_absorption_g_per_100g": "30-60", "water_absorption_capacity": "low", "surface_charge_…
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (2)
JECFA Evaluation
CALCIUM PYROPHOSPHATE | 1982 | Group MTDI for phosphorus from all sources, expressed as P | TRS 683-JECFA 26/25 | FAS 17-JECFA 26/151
Source: WHO/JECFA
EU Food Improvement
Food additives
Source: EU Food Improvement Agents
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Abrasive
Flavouring and nutrient
Stabilizing agent
Regulatory List Membership (1)
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for Calcium Pyrophosphate.
Regulatory Flags
fda_food_additive
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Calcium Pyrophosphate by CAS number or substance name.
Studies
1
Lowest NOAEL
30 mg/kg bw/day
Highest NOAEL
30 mg/kg bw/day
COSMOS DB
Known Synonyms
Diphosphoric acid, calcium salt (1:2)
C 54-80
Calcium diphosphate (Ca2P2O7)
Calcium metaphosphate oxide (Ca0.67(PO3)0.66O0.34)
Calcium phosphate (Ca2P2O7)
Calcium pyrophosphate (Ca2P2O7)
CALCIUMPYROPHOSPHAT(2:1)
Dicalcium diphosphate
dicalcium pyrophosphate
Dicalciumpyrophosphat
NP 970-10
Pyrophosphate de dicalcium
Pyrophosphoric acid, calcium salt (1:2)
Chemical Function
Abrasive
Stabilizing agent
Flavouring and nutrient
Regulatory Lists
inert_ingredient; non_food_use; Pesticides
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in food safety data.
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
Dicalcium diphosphate
E Number
E450vi
ADI
40 mg/kg bw
Food Category
emulsifier
Frequently Asked Questions
Is Calcium Pyrophosphate allowed in the EU?
Calcium Pyrophosphate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Calcium Pyrophosphate do in cosmetics?
Calcium Pyrophosphate functions as: Abrasive, oral care agent. It is classified as a cosmetic ingredient in our database. CAS number: 7790-76-3.
What is the NOAEL for Calcium Pyrophosphate?
The NOAEL (No Observed Adverse Effect Level) for Calcium Pyrophosphate is 30 mg/kg bw/day based on a Subchronic study via oral route in rat. Source: COSMOS DB.
Is Calcium Pyrophosphate used outside cosmetics?
Calcium Pyrophosphate also appears in industrial chemical safety and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Calcium Pyrophosphate compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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