Is Phenethyl Phenylacetate safe in cosmetics?
Phenethyl Phenylacetate has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
GOOD
Cosmetic Ingredient
Phenethyl Phenylacetate
Also known as: Benzeneacetic acid, 2-phenylethyl ester, 3-09-00-02183, Benzylcarbinyl phenylacetate, Benzylcarbinyl alpha-toluate, BRN 2214383 (+9 more)
INCI: PHENETHYL PHENYLACETATE
Phenethyl Phenylacetate (CAS 102-20-5) is a cosmetic cosmetic ingredient functioning as Fragrance ingredient. NOAEL 200 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety, pharmaceutical, and food safety data.
Function
Fragrance ingredient
Editorial assessment
GOOD
Preliminary editorial note — not a computed safety verdict.
Chemistry & Identifiers
IUPAC Name
2-phenylethyl 2-phenylacetate
InChIKey
ZOZIRNMDEZKZHM-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
GRAS for food use; permitted in cosmetics as fragrance. FEMA 2867
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Phenethyl Phenylacetate.
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Phenethyl Phenylacetate across SCCS product categories, with measured dermal absorption where available.
HRIPT Human Patch Test Studies
5 human repeat insult patch tests aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 1296 | - | - |
| HRIPT | - | 0 | - | - | - |
| HRIPT | - | 0 | - | - | - |
| HMT | - | 0 | 1296 | - | - |
| HRIPT | - | 0 | - | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (5)
JECFA Number
999
Source: WHO/JECFA
JECFA Evaluation
2-PHENYLETHYL alpha-TOLUATE | 2002 | No safety concern at current levels of intake when used as a flavouring agent | TRS 913-JECFA 59/53 | FAS 50-JECFA 59/215
Source: WHO/JECFA
JECFA Evaluation
BENZYLCARBINYL PHENYLACETATE | 2002 | No safety concern at current levels of intake when used as a flavouring agent | TRS 913-JECFA 59/53 | FAS 50-JECFA 59/215
Source: WHO/JECFA
JECFA Evaluation
BENZYLCARBINYL alpha-TOLUATE | 2002 | No safety concern at current levels of intake when used as a flavouring agent | TRS 913-JECFA 59/53 | FAS 50-JECFA 59/215
Source: WHO/JECFA
JECFA Evaluation
PHENETHYL PHENYLACETATE | 2002 | No safety concern at current levels of intake when used as a flavouring agent | TRS 913-JECFA 59/53 | FAS 50-JECFA 59/215
Source: WHO/JECFA
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (3)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Editorial summary
Preliminary editorial summary for Phenethyl Phenylacetate — not a computed safety verdict. See the sourced toxicological data above.
Regulatory Flags
fragrance-component
ifra_fragrance
fda_food_additive
jecfa_safe
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Phenethyl Phenylacetate by CAS number or substance name.
Studies
27
Lowest NOAEL
50 mg/kg bw/day
Highest NOAEL
1870 mg/kg bw/day
ECHA
Known Synonyms
Benzeneacetic acid, 2-phenylethyl ester
3-09-00-02183
Benzylcarbinyl phenylacetate
Benzylcarbinyl alpha-toluate
BRN 2214383
EINECS 203-013-1
FEMA No. 2866
NSC 6676
Phenethyl alpha-toluate
Phenylacetic acid, phenethyl ester
2-Phenylethyl benzeneacetate
Phenylethyl phenylacetate
2-Phenylethyl alpha-toluate
UNII-5J5OJ7GH15
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
IFRA Transparency
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
consumer_product
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical and food safety data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3183441
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
PHENETHYL PHENYLACETATE
ADI
No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
Food Category
flavoring
Frequently Asked Questions
Is Phenethyl Phenylacetate allowed in the EU?
Phenethyl Phenylacetate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Phenethyl Phenylacetate do in cosmetics?
Phenethyl Phenylacetate functions as: Fragrance ingredient. It is classified as a cosmetic ingredient in our database. CAS number: 102-20-5.
Is Phenethyl Phenylacetate used outside cosmetics?
Phenethyl Phenylacetate also appears in industrial chemical safety, pharmaceutical, and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Phenethyl Phenylacetate compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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