Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
8 study endpoints found for Phenethyl Phenylacetate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 500 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| dose_tested | 500 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 200 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 200 mg/kg bw/day | oral | - | oral | REACH |
| NOAEL | 500 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 500 other | oral | rat | oral | REACH |
| NOAEL | >1000 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 1000 mg/kg bw/day | oral | rat | oral | REACH |
Expert Verdict
Classified as skin and eye irritant at neat/high concentration (H315, H319) but safe at typical fragrance use levels.
Regulatory Flags
Frequently Asked Questions
Is Phenethyl Phenylacetate safe in cosmetics?
Classified as skin and eye irritant at neat/high concentration (H315, H319) but safe at typical fragrance use levels. The EU classifies Phenethyl Phenylacetate as "permitted". Safety rating: GOOD. 8 toxicological study endpoint(s) are available in our database.
Is Phenethyl Phenylacetate allowed in the EU?
Phenethyl Phenylacetate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Phenethyl Phenylacetate do in cosmetics?
Phenethyl Phenylacetate functions as: Fragrance ingredient. It is classified as a cosmetic ingredient in our database. CAS number: 102-20-5.
What is the Margin of Safety for Phenethyl Phenylacetate?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Phenethyl Phenylacetate?
The NOAEL (No Observed Adverse Effect Level) for Phenethyl Phenylacetate is 500 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 8 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
Check Phenethyl Phenylacetate compliance across multiple jurisdictions:
Related Ingredients
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