Moderate Preservative Sensitization Data

PHMB Cosmetic

INCI: POLYAMINOPROPYL BIGUANIDE

CAS Number
133029-32-0
Function
Preservative
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status restricted
EU Max Conc. 0.3%
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes No specific restrictions

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Sensitization Profile

Contact sensitization data for PHMB Cosmetic based on clinical patch test studies and IFRA standards.

Sensitization Rate
low
Allergen Class
preservative
EU Allergen Listed
no
Patch Test Positive Rate
0.3%
Cross-reactivity Group
formaldehyde-releaser-group
Reaction Type
contact-dermatitis

Source: ESSCA 2019/20; IVDK; FDA

Expert Verdict

PHMB has established safety at restricted concentrations up to 0.3% in cosmetics, with adequate margin of safety established by SCCS.

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Concern Level: Moderate

Regulatory Flags

EU Restricted CMR Allergen

Frequently Asked Questions

Is PHMB Cosmetic safe in cosmetics?

PHMB has established safety at restricted concentrations up to 0.3% in cosmetics, with adequate margin of safety established by SCCS. The EU classifies PHMB Cosmetic as "restricted". Safety rating: MODERATE.

Is PHMB Cosmetic allowed in the EU?

PHMB Cosmetic EU regulatory status: restricted. Maximum allowed concentration: 0.3%. This is based on EU Regulation 1223/2009 and its amendments.

What does PHMB Cosmetic do in cosmetics?

PHMB Cosmetic functions as: Preservative. It is classified as a Preservative in our database. CAS number: 133029-32-0.

What is the Margin of Safety for PHMB Cosmetic?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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