Pidobenzone

INCI: PIDOBENZONE

CAS Number
138506-45-3
Function
Skin lightening / depigmenting agent (tyrosinase inhibitor, melanin synthesis inhibitor)
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Not an OTC monograph active; not specifically regulated as cosmetic

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Melanin synthesis inhibitor subject to regulatory scrutiny for skin-lightening claims in EU/ASEAN; ester bond may hydrolyze to p-hydroxyphenol and pyroglutamic acid; very limited published clinical and toxicological data available.

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Concern Level: High

Frequently Asked Questions

Is Pidobenzone safe in cosmetics?

Melanin synthesis inhibitor subject to regulatory scrutiny for skin-lightening claims in EU/ASEAN; ester bond may hydrolyze to p-hydroxyphenol and pyroglutamic acid; very limited published clinical and toxicological data available. The EU classifies Pidobenzone as "permitted". Safety rating: MODERATE.

Is Pidobenzone allowed in the EU?

Pidobenzone EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Pidobenzone do in cosmetics?

Pidobenzone functions as: Skin lightening / depigmenting agent (tyrosinase inhibitor, melanin synthesis inhibitor). It is classified as a cosmetic ingredient in our database. CAS number: 138506-45-3.

What is the Margin of Safety for Pidobenzone?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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