Is Pidobenzone safe in cosmetics?
Pidobenzone has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Pidobenzone
INCI: PIDOBENZONE
Pidobenzone (CAS 138506-45-3) is a cosmetic cosmetic ingredient functioning as Skin lightening / depigmenting agent (tyrosinase inhibitor, melanin synthesis. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical data.
View industrial chemical safety profile for CAS 138506-45-3 →
Auto-generated CPSR Part A draft with source citations
Function
Skin lightening / depigmenting agent (tyrosinase inhibitor, melanin synthesis inhibitor)
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
(4-hydroxyphenyl) (2S)-5-oxopyrrolidine-2-carboxylate
InChIKey
SDJPNDMWNUPUFI-VIFPVBQESA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Not an OTC monograph active; not specifically regulated as cosmetic
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Pidobenzone.
Calculate MoS for your specific formulation with the MoS Calculator.
Expert Verdict
Expert safety assessment and concern-level summary for Pidobenzone.
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
PIDOBENZONE
ChEMBL ID
CHEMBL2106955
Max Phase
2
Frequently Asked Questions
Is Pidobenzone allowed in the EU?
Pidobenzone EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Pidobenzone do in cosmetics?
Pidobenzone functions as: Skin lightening / depigmenting agent (tyrosinase inhibitor, melanin synthesis inhibitor). It is classified as a cosmetic ingredient in our database. CAS number: 138506-45-3.
Is Pidobenzone used outside cosmetics?
Pidobenzone also appears in pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Pidobenzone compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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Is Pidobenzone in Your Products?
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