Is Pinacol safe in cosmetics?
Pinacol has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Pinacol
Also known as: 4-01-00-02575, BRN 1340501, EINECS 200-933-5, UNII-527QE7I5CO
INCI: PINACOL
Pinacol (CAS 76-09-5) is a cosmetic cosmetic ingredient functioning as Solvent, Viscosity Controlling. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 76-09-5 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Pinacol is classified GHS Danger (H228, H315, H319, H335) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Solvent, Viscosity Controlling
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
2,3-dimethylbutane-2,3-diol
InChIKey
IVDFJHOHABJVEH-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Not specifically regulated for cosmetics; no GRAS designation for this use
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Pinacol.
Calculate MoS for your specific formulation with the MoS Calculator.
Sensitization AOP Dashboard
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
NESIL
5400 µg/cm²
GHS: 1B
Human: positive
Source: HPPT: [747] Epstein WL (1975): Report to RIFM, 6 May and 15 August, unpublished.
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 5400 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Intermediate
Tonnage Band
Intermediate use only
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Fragrance
Expert Verdict
Expert safety assessment and concern-level summary for Pinacol.
Known Synonyms
4-01-00-02575
BRN 1340501
EINECS 200-933-5
UNII-527QE7I5CO
Chemical Function
Fragrance
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3289669
Frequently Asked Questions
Is Pinacol allowed in the EU?
Pinacol EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Pinacol do in cosmetics?
Pinacol functions as: Solvent, Viscosity Controlling. It is classified as a cosmetic ingredient in our database. CAS number: 76-09-5.
Is Pinacol used outside cosmetics?
Pinacol also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Pinacol have different safety status in cosmetics vs industrial chemicals?
Pinacol is classified GHS Danger (H228, H315, H319, H335) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Pinacol compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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